WEE2 ELISA Kit for Pig(Sus scrofa) | EIAab.comWEE2 ELISA Kit for Pig(Sus scrofa)

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Index > Protein center > WEE2(Gene name) > Pig

WEE2 (Gene name),

Wee1-like protein kinase 2 (Protein name ), WEE2_PIG from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

WEE2(WEE1B);

Protein name:

Wee1-like protein kinase 2;

Alternative:

Wee1B kinase(pWee1B;pigWee1B);Wee1-like protein kinase 1B;

Organism:

Pig (Sus scrofa).

General Annotation

Sub Unit:

N/A

Function:

Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

565

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

565:

KSAKSSSFTW | GQSSP

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Ssc.43347

String:

A4PES0

STRING:

9823.ENSSSCP00000017471

Pfam:

PF00069

KEGG:

ssc:100048934

Uniprot:

A4PES0

FOR

ELISA Kit for Pig Wee1-like protein kinase 2

CLIA Kit for Pig Wee1-like protein kinase 2

Polyclonal Antibody for Pig Wee1-like protein kinase 2

Monoclonal Antibody for Pig Wee1-like protein kinase 2

Protein for Pig Wee1-like protein kinase 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Critical effect of pigWee1B on the regulation of meiotic resumption in porcine immature oocytes."
Shimaoka T. , Nishimura T. , Kano K. , Naito K.
Cell Cycle8:2375-2384(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
2.

"Insufficient amount of Cdc2 and continuous activation of Wee1 B are the cause of meiotic failure in porcine growing oocytes."
Nishimura T. , Shimaoka T. , Kano K. , Naito K.
J. Reprod. Dev.55:553-557(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN SMALL OOCYTES
3.

"Analyses of the regulatory mechanism of porcine WEE1B: the phosphorylation sites of porcine WEE1B and mouse WEE1B are different."
Shimaoka T. , Nishimura T. , Kano K. , Naito K.
J. Reprod. Dev.57:223-228(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;PHOSPHORYLATION AT SER-77;MUTAGENESIS OF SER-77; SER-118; SER-133; SER-149 AND 174-ARG-LYS-175

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