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Index > Protein center > WHAMM(Gene name) > Human
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  • WHAMM (Gene name),
  • WASP homolog-associated protein with actin, membranes and microtubules (Protein name ),  WHAMM_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    WHAMM(KIAA1971;WHDC1);
    Protein name:
    WASP homolog-associated protein with actin, membranes and microtubules;
    Alternative:
    WAS protein homology region 2 domain-containing protein 1(WH2 domain-containing protein 1);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with actin, ACTR3 and microtubules.
    Function:
    Acts as a nucleation-promoting factor (NPF) that stimulates Arp2/3-mediated actin polymerization both at the Golgi apparatus and along tubular membranes. Involved as a regulator of Golgi positioning and morphology. Participates in vesicle transport between the reticulum endoplasmic and the Golgi complex.
    Subcellular Location:
    Cytoplasm Endoplasmic reticulum-Golgi intermediate compartment Cytoplasmic vesicle membrane Golgi apparatus cis-Golgi network Localized to a perinuclear compartment near the microtubule-organizing center (MTOC). Also detected on tubulo-vesicular structures in the cell periphery that frequently localized along microtubules.
    Protein Attributes:
    Sequence length:
    809
    Sequence:
    50:
    MEDEQPDSLE | GWVPVREGLF | AEPERHRLRF | LVAWNGAEGK | FAVTCHDRTA | 
    100:
    QQRRLREGAR | LGPEPEPKPE | AAVSPSSWAG | LLSAAGLRGA | HRQLAALWPP | 
    150:
    LERCFPRLPP | ELDVGGGGAW | GLGLGLWALL | WPTRAGPGEA | ALQELCGQLE | 
    200:
    RYLGAAADGC | GGATVRDALF | PAEGGAADCE | SPREFRERAL | RARWVEADAR | 
    250:
    LRQVIQGHGK | ANTMVALMNV | YQEEDEAYQE | LVTVATMFFQ | YLLQPFRAMR | 
    300:
    EVATLCKLDI | LKSLDEDDLG | PRRVVALEKE | AEEWTRRAEE | AVVSIQDITV | 
    350:
    NYFKETVKAL | AGMQKEMEQD | AKRFGQAAWA | TAIPRLEKLQ | LMLARETLQL | 
    400:
    MRAKELCLNH | KRAEIQGKME | DLPEQEKNTN | VVDELEIQFY | EIQLELYEVK | 
    450:
    FEILKNEEIL | LTTQLDSLKR | LIKEKQDEVV | YYDPCENPEE | LKVIDCVVGL | 
    500:
    QDDKNLEVKE | LRRQCQQLES | KRGRICAKRA | SLRSRKDQCK | ENHRFRLQQA | 
    550:
    EESIRYSRQH | HSIQMKRDKI | KEEEQKKKEW | INQERQKTLQ | RLRSFKDKRL | 
    600:
    AQSVRNTSGS | EPVAPNLPSD | LSQQMCLPAS | HAVSVIHPSS | RKTRGVPLSE | 
    650:
    AGNVKSPKCQ | NCHGNIPVQV | FVPVGDQTHS | KSSEELSLPP | PPPPPPPPPP | 
    700:
    PPPPPPPPLR | ALSSSSQAAT | HQNLGFRAPV | KDDQPRPLVC | ESPAERPRDS | 
    750:
    LESFSCPGSM | DEVLASLRHG | RAPLRKVEVP | AVRPPHASIN | EHILAAIRQG | 
    800:
    VKLKKVHPDL | GPNPSSKPTS | NRRTSDLERS | IKAALQRIKR | VSADSEEDSD | 
    809:
    EQDPGQWDG
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    MIM:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human WASP homolog-associated protein with actin, membranes and microtubules
    ELISA Kit for Human WASP homolog-associated protein with actin, membranes and microtubules
    CLIA Kit for Human WASP homolog-associated protein with actin, membranes and microtubules
    CLIA Kit for Human WASP homolog-associated protein with actin, membranes and microtubules
    Polyclonal Antibody for Human WASP homolog-associated protein with actin, membranes and microtubules
    Polyclonal Antibody for Human WASP homolog-associated protein with actin, membranes and microtubules
    Monoclonal Antibody for Human WASP homolog-associated protein with actin, membranes and microtubules
    Monoclonal Antibody for Human WASP homolog-associated protein with actin, membranes and microtubules
    Protein for Human WASP homolog-associated protein with actin, membranes and microtubules
    Protein for Human WASP homolog-associated protein with actin, membranes and microtubules

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    Linearity
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    References
    1. 1.
      "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins."
      Nagase T. , Kikuno R. , Ohara O.
      DNA Res.8:319-327(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    2. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 568-809
      tissue: Thymus.
    3. 4.
      "WHAMM is an Arp2/3 complex activator that binds microtubules and functions in ER to Golgi transport."
      Campellone K.G. , Webb N.J. , Znameroski E.A. , Welch M.D.
      Cell134:148-161(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH ACTR3 AND MICROTUBULES;MUTAGENESIS OF TRP-807
    4. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-606;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    5. 6.
      "RhoD regulates cytoskeletal dynamics via the actin nucleation-promoting factor WASp homologue associated with actin Golgi membranes and microtubules."
      Gad A.K. , Nehru V. , Ruusala A. , Aspenstrom P.
      Mol. Biol. Cell23:4807-4819(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH RHOD
    6. 7.
      "Structural insights into WHAMM-mediated cytoskeletal coordination during membrane remodeling."
      Shen Q.T. , Hsiue P.P. , Sindelar C.V. , Welch M.D. , Campellone K.G. , Wang H.W.
      J. Cell Biol.199:111-124(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT;ELECTRON MICROSCOPY IN COMPLEX WITH MICROTUBULES
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