WIBG ELISA Kit for Human(Homo sapiens) | EIAab.comWIBG ELISA Kit for Human(Homo sapiens)

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Index > Protein center > WIBG(Gene name) > Human

WIBG (Gene name),

Partner of Y14 and mago (Protein name ), WIBG_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

WIBG(PYM);

Protein name:

Partner of Y14 and mago;

Alternative:

Protein wibg homolog;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts (via N-terminus) with MAGOH and RBM8A; the interaction is direct. Associates (eIF2A-like region) with the 40S ribosomal subunit and the 48S preinitiation complex.

Function:

Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmarks for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as a EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC.

Subcellular Location:

Cytoplasm Nucleus nucleolus Nucleus nucleoplasm Shuttles between the nucleus and the cytoplasm. Nuclear export is mediated by XPO1/CRM1.

Protein Attributes:

Sequence length:

204

Sequence:

50:

100:

150:

200:

204:

ELGL