Protein name:
    WNT1-inducible-signaling pathway protein 1 (WISP-1) ;
    
    Alternative:
    
    Wnt-1-induced secreted protein ;CCN family member 4 ;
    
    
 
    Organism:
        
        
        
        
        
        
    
        Human  (Homo sapiens).  
    
 
General Annotation
    Function:
    Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the anti-apoptotic Bcl-X(L) protein. Adheres to skin and melanoma fibroblasts. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan.
    
 
    
        
        Subcellular Location:
        
    
     
     
      Secreted 
     
  
    
 
    
    Protein Attributes:
    
    50:
    MRWFLPWTLA |  AVTAAAASTV |  LATALSPAPT |  TMDFTPAPLE |  DTSSRPQFCK |  
    
 
    100:
    WPCECPPSPP |  RCPLGVSLIT |  DGCECCKMCA |  QQLGDNCTEA |  AICDPHRGLY |  
    
 
    150:
    CDYSGDRPRY |  AIGVCAQVVG |  VGCVLDGVRY |  NNGQSFQPNC |  KYNCTCIDGA |  
    
 
    200:
    VGCTPLCLRV |  RPPRLWCPHP |  RRVSIPGHCC |  EQWVCEDDAK |  RPRKTAPRDT |  
    
 
    250:
    GAFDAVGEVE |  AWHRNCIAYT |  SPWSPCSTSC |  GLGVSTRISN |  VNAQCWPEQE |  
    
 
    300:
    SRLCNLRPCD |  VDIHTLIKAG |  KKCLAVYQPE |  ASMNFTLAGC |  ISTRSYQPKY |  
    
 
    350:
    CGVCMDNRCC |  IPYKSKTIDV |  SFQCPDGLGF |  SRQVLWINAC |  FCNLSCRNPN |  
    
 
    367:
    DIFADLESYP |  DFSEIAN
    
 
      Vaild Sequence:
    
 
Related Databases
Uniprot:
 
 
    
        
        ELISA Kit
         
        
        CLIA Kit
         
        
        Polyclonal Antibody
         
        
        Monoclonal Antibody
         
        
        Protein
         
        
     
FOR
    
        
        Mouse
         
        
        Human
         
        
        Rat
         
        
     
    
        ELISA Kit for Human WISP-1
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
    
    
    
    
 
    
        ELISA Kit for Human WISP-1
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
    
    
    
    
 
    
        ELISA Kit for Human WISP-1
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
    
    
    
    
 
    
        CLIA Kit for Human WISP-1
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
    
    
    
    
 
    
        CLIA Kit for Human WISP-1
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
 
    
        CLIA Kit for Human WISP-1
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Human WISP-1
        
     
    
    
    
    
   
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Human WISP-1
        
     
    
    
    
    
   
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Human WISP-1
        
     
    
    
    
    
   
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Human WISP-1
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Human WISP-1
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Human WISP-1
        
     
    
    
    
    
    
    
 
 
 
 
 
 
 
 
    R&D Technical Data
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
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    Precision
    
    
    
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    Recovery
    
    
    
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    Linearity
    
    
    
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        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
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    References
    
    
        
            
        
            
                1.
                
                    
                        
                            "WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors." 
                        
                        
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                        [
PubMed ]
                        [
Europe PMC ]
                        [
Abstract ]
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1) 
                    
                    
                    tissue :
                    
Fetal kidney . tissue :
                    
Lung .  
             
         
            
        
            
                2.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2) 
                    
                    
                    tissue :
                    
Gastric carcinoma .  
             
         
            
        
            
                3.
                
                    
                        
                            "Multiple alternatively spliced variants of WISP1 are overexpressed in pancreatic cancer." 
                        
                        
                            Li Z. 
                        ,
                            
Chiao P.J. 
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Evans D.B. 
                        
                        
                        
                            Submitted (2002-12) to the EMBL/GenBank/DDBJ databases
                        
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3; 4 AND 5) 
                    
                    
                 
             
         
            
        
            
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                        [
PubMed ]
                        [
Europe PMC ]
                        [
Abstract ]
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5) 
                    
                    
                    tissue :
                    
Synovium . tissue :
                    
Uterus .  
             
         
            
        
            
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                        [
PubMed ]
                        [
Europe PMC ]
                        [
Abstract ]
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] 
                    
                    
                 
             
         
            
        
            
                6.
                
                    
                        
                        
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                        ,
                            Venter J.C. 
                        
                             
                              more...   
                             
                        
                        
                            Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
                        
                        
                    
 
                    
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                        Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] 
                    
                    
                 
             
         
            
        
            
                7.
                
                    
                    
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                        Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1) 
                    
                    
                    tissue :
                    
Lung .  
             
         
            
        
            
                8.
                
                    
                    
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                        Cited for FUNCTION IN WNT1 SIGNALING 
                    
                    
                 
             
         
            
        
            
                9.
                
                    
                    
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                        Cited for FUNCTION IN TP53-MEDIATED APOPTOSIS 
                    
                    
                 
             
         
            
        
            
                10.
                
                    
                    
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                        Cited for INTERACTION WITH DECORIN AND BIGLYCAN