Gene name:
WNK1 (HSN2;KDP;KIAA0344;PRKWNK1) ;
Protein name:
Serine/threonine-protein kinase WNK1 ;
Alternative:
Kinase deficient protein ;Erythrocyte 65 kDa protein (p65) ;Protein kinase with no lysine 1 (hWNK1) ;Protein kinase lysine-deficient 1 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with SYT2 (By similarity). Interacts with WNK3 and WNK4.
Function:
Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D and SGK1. Controls sodium and chloride ion transport by inhibiting the activity of WNK4, by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation. WNK1 may also play a role in actin cytoskeletal reorganization. Phosphorylates NEDD4L.
Subcellular Location:
Cytoplasm
Protein Attributes:
50:
MSGGAAEKQS | STPGSLFLSP | PAPAPKNGSS | SDSSVGEKLG | AAAADAVTGR |
100:
TEEYRRRRHT | MDKDSRGAAA | TTTTTEHRFF | RRSVICDSNA | TALELPGLPL |
150:
SLPQPSIPAA | VPQSAPPEPH | REETVTATAT | SQVAQQPPAA | AAPGEQAVAG |
200:
PAPSTVPSST | SKDRPVSQPS | LVGSKEEPPP | ARSGSGGGSA | KEPQEERSQQ |
250:
QDDIEELETK | AVGMSNDGRF | LKFDIEIGRG | SFKTVYKGLD | TETTVEVAWC |
300:
ELQDRKLTKS | ERQRFKEEAE | MLKGLQHPNI | VRFYDSWEST | VKGKKCIVLV |
350:
TELMTSGTLK | TYLKRFKVMK | IKVLRSWCRQ | ILKGLQFLHT | RTPPIIHRDL |
400:
KCDNIFITGP | TGSVKIGDLG | LATLKRASFA | KSVIGTPEFM | APEMYEEKYD |
450:
ESVDVYAFGM | CMLEMATSEY | PYSECQNAAQ | IYRRVTSGVK | PASFDKVAIP |
500:
EVKEIIEGCI | RQNKDERYSI | KDLLNHAFFQ | EETGVRVELA | EEDDGEKIAI |
550:
KLWLRIEDIK | KLKGKYKDNE | AIEFSFDLER | DVPEDVAQEM | VESGYVCEGD |
600:
HKTMAKAIKD | RVSLIKRKRE | QRQLVREEQE | KKKQEESSLK | QQVEQSSASQ |
650:
TGIKQLPSAS | TGIPTASTTS | ASVSTQVEPE | EPEADQHQQL | QYQQPSISVL |
700:
SDGTVDSGQG | SSVFTESRVS | SQQTVSYGSQ | HEQAHSTGTV | PGHIPSTVQA |
750:
QSQPHGVYPP | SSVAQGQSQG | QPSSSSLTGV | SSSQPIQHPQ | QQQGIQQTAP |
800:
PQQTVQYSLS | QTSTSSEATT | AQPVSQPQAP | QVLPQVSAGK | QLPVSQPVPT |
850:
IQGEPQIPVA | TQPSVVPVHS | GAHFLPVGQP | LPTPLLPQYP | VSQIPISTPH |
900:
VSTAQTGFSS | LPITMAAGIT | QPLLTLASSA | TTAAIPGVST | VVPSQLPTLL |
950:
QPVTQLPSQV | HPQLLQPAVQ | SMGIPANLGQ | AAEVPLSSGD | VLYQGFPPRL |
1000:
PPQYPGDSNI | APSSNVASVC | IHSTVLSPPM | PTEVLATPGY | FPTVVQPYVE |
1050:
SNLLVPMGGV | GGQVQVSQPG | GSLAQAPTTS | SQQAVLESTQ | GVSQVAPAEP |
1100:
VAVAQTQATQ | PTTLASSVDS | AHSDVASGMS | DGNENVPSSS | GRHEGRTTKR |
1150:
HYRKSVRSRS | RHEKTSRPKL | RILNVSNKGD | RVVECQLETH | NRKMVTFKFD |
1200:
LDGDNPEEIA | TIMVNNDFIL | AIERESFVDQ | VREIIEKADE | MLSEDVSVEP |
1250:
EGDQGLESLQ | GKDDYGFSGS | QKLEGEFKQP | IPASSMPQQI | GIPTSSLTQV |
1300:
VHSAGRRFIV | SPVPESRLRE | SKVFPSEITD | TVAASTAQSP | GMNLSHSASS |
1350:
LSLQQAFSEL | RRAQMTEGPN | TAPPNFSHTG | PTFPVVPPFL | SSIAGVPTTA |
1400:
AATAPVPATS | SPPNDISTSV | IQSEVTVPTE | EGIAGVATST | GVVTSGGLPI |
1450:
PPVSESPVLS | SVVSSITIPA | VVSISTTSPS | LQVPTSTSEI | VVSSTALYPS |
1500:
VTVSATSASA | GGSTATPGPK | PPAVVSQQAA | GSTTVGATLT | SVSTTTSFPS |
1550:
TASQLCIQLS | SSTSTPTLAE | TVVVSAHSLD | KTSHSSTTGL | AFSLSAPSSS |
1600:
SSPGAGVSSY | ISQPGGLHPL | VIPSVIASTP | ILPQAAGPTS | TPLLPQVPSI |
1650:
PPLVQPVANV | PAVQQTLIHS | QPQPALLPNQ | PHTHCPEVDS | DTQPKAPGID |
1700:
DIKTLEEKLR | SLFSEHSSSG | AQHASVSLET | SLVIESTVTP | GIPTTAVAPS |
1750:
KLLTSTTSTC | LPPTNLPLGT | VALPVTPVVT | PGQVSTPVST | TTSGVKPGTA |
1800:
PSKPPLTKAP | VLPVGTELPA | GTLPSEQLPP | FPGPSLTQSQ | QPLEDLDAQL |
1850:
RRTLSPEMIT | VTSAVGPVSM | AAPTAITEAG | TQPQKGVSQV | KEGPVLATSS |
1900:
GAGVFKMGRF | QVSVAADGAQ | KEGKNKSEDA | KSVHFESSTS | ESSVLSSSSP |
1950:
ESTLVKPEPN | GITIPGISSD | VPESAHKTTA | SEAKSDTGQP | TKVGRFQVTT |
2000:
TANKVGRFSV | SKTEDKITDT | KKEGPVASPP | FMDLEQAVLP | AVIPKKEKPE |
2050:
LSEPSHLNGP | SSDPEAAFLS | RDVDDGSGSP | HSPHQLSSKS | LPSQNLSQSL |
2100:
SNSFNSSYMS | SDNESDIEDE | DLKLELRRLR | DKHLKEIQDL | QSRQKHEIES |
2150:
LYTKLGKVPP | AVIIPPAAPL | SGRRRRPTKS | KGSKSSRSSS | LGNKSPQLSG |
2200:
NLSGQSAASV | LHPQQTLHPP | GNIPESGQNQ | LLQPLKPSPS | SDNLYSAFTS |
2250:
DGAISVPSLS | APGQGTSSTN | TVGATVNSQA | AQAQPPAMTS | SRKGTFTDDL |
2300:
HKLVDNWARD | AMNLSGRRGS | KGHMNYEGPG | MARKFSAPGQ | LCISMTSNLG |
2350:
GSAPISAASA | TSLGHFTKSM | CPPQQYGFPA | TPFGAQWSGT | GGPAPQPLGQ |
2382:
FQPVGTASLQ | NFNISNLQKS | ISNPPGSNLR | TT
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Pig
Human
Mouse
Rat
ELISA Kit for Human Serine/threonine-protein kinase WNK1
ELISA Kit for Human Serine/threonine-protein kinase WNK1
ELISA Kit for Human Serine/threonine-protein kinase WNK1
ELISA Kit for Human Serine/threonine-protein kinase WNK1
CLIA Kit for Human Serine/threonine-protein kinase WNK1
CLIA Kit for Human Serine/threonine-protein kinase WNK1
CLIA Kit for Human Serine/threonine-protein kinase WNK1
CLIA Kit for Human Serine/threonine-protein kinase WNK1
Polyclonal Antibody for Human Serine/threonine-protein kinase WNK1
Polyclonal Antibody for Human Serine/threonine-protein kinase WNK1
Polyclonal Antibody for Human Serine/threonine-protein kinase WNK1
Polyclonal Antibody for Human Serine/threonine-protein kinase WNK1
Monoclonal Antibody for Human Serine/threonine-protein kinase WNK1
Monoclonal Antibody for Human Serine/threonine-protein kinase WNK1
Monoclonal Antibody for Human Serine/threonine-protein kinase WNK1
Monoclonal Antibody for Human Serine/threonine-protein kinase WNK1
Protein for Human Serine/threonine-protein kinase WNK1
Protein for Human Serine/threonine-protein kinase WNK1
Protein for Human Serine/threonine-protein kinase WNK1
Protein for Human Serine/threonine-protein kinase WNK1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;CHROMOSOMAL LOCATION;VARIANTS PRO-1056; SER-1506 AND ILE-1808
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Heart .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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tissue :
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS PRO-1056; SER-1506 AND ILE-1808
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 1-668 (ISOFORMS 1/2);FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
tissue :
Mammary carcinoma .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 69-2382 (ISOFORM 2);VARIANTS PRO-1056 AND SER-1506
tissue :
Brain .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SEQUENCE REVISION TO N-TERMINUS
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 163-175;GLYCOSYLATION
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (N-TERMINUS OF ISOFORM 3);ALTERNATIVE PROMOTER USAGE;ALTERNATIVE SPLICING;TISSUE SPECIFICITY
tissue :
Kidney .
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1/4/5)
tissue :
Placenta .
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,
Pryse-Phillips W.
,
Goldberg Y.P.
,
Younghusband H.B.
,
Hayden M.R.
,
Sherrington R.
,
Rouleau G.A.
,
Samuels M.E.
more...
Am. J. Hum. Genet.74:1064-1073(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION (ISOFORMS 4/5);FUNCTION;INVOLVEMENT IN HSAN2A
12.
"Human hypertension caused by mutations in WNK kinases."
Wilson F.H.
,
Disse-Nicodeme S.
,
Choate K.A.
,
Ishikawa K.
,
Nelson-Williams C.
,
Desitter I.
,
Gunel M.
,
Milford D.V.
,
Lipkin G.W.
,
Achard J.-M.
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,
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,
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,
Unwin R.J.
,
Mayan H.
,
Simon D.B.
,
Farfel Z.
,
Jeunemaitre X.
,
Lifton R.P.
more...
Science293:1107-1112(2001)
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PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INVOLVEMENT IN PHA2C
13.
"Two mutations in the HSN2 gene explain the high prevalence of HSAN2 in French Canadians."
Roddier K.
,
Thomas T.
,
Marleau G.
,
Gagnon A.M.
,
Dicaire M.J.
,
St Denis A.
,
Gosselin I.
,
Sarrazin A.M.
,
Larbrisseau A.
,
Lambert M.
,
Vanasse M.
,
Gaudet D.
,
Rouleau G.A.
,
Brais B.
Neurology64:1762-1767(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INVOLVEMENT IN HSAN2A
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2002 AND SER-2032;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1261;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
16.
"Mutations in the nervous system--specific HSN2 exon of WNK1 cause hereditary sensory neuropathy type II."
Shekarabi M.
,
Girard N.
,
Riviere J.B.
,
Dion P.
,
Houle M.
,
Toulouse A.
,
Lafreniere R.G.
,
Vercauteren F.
,
Hince P.
,
Laganiere J.
,
Rochefort D.
,
Faivre L.
,
Samuels M.
,
Rouleau G.A.
J. Clin. Invest.118:2496-2505(2008)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ALTERNATIVE SPLICING (ISOFORMS 4 AND 5);INVOLVEMENT IN HSAN2A
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19; SER-1261; SER-2011; SER-2012; SER-2027; SER-2029 AND SER-2032;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1978;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Leukemic T-cell .
21.
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V.
,
Vermeulen M.
,
Santamaria A.
,
Kumar C.
,
Miller M.L.
,
Jensen L.J.
,
Gnad F.
,
Cox J.
,
Jensen T.S.
,
Nigg E.A.
,
Brunak S.
,
Mann M.
Sci. Signal.3:RA3-RA3(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19; SER-1261; SER-1978; SER-2032 AND SER-2121;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
22.
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Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
23.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2027; SER-2029 AND SER-2032;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
24.
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Cited for : UBIQUITINATION BY KLHL2
25.
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Cited for : INTERACTION WITH KLHL3
26.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : UBIQUITINATION;INTERACTION WITH KLHL3
27.
"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T.
,
Jones S.
,
Wood L.D.
,
Parsons D.W.
,
Lin J.
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Barber T.D.
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Wu L.
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Liu C.
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Parmigiani G.
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Park B.H.
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Bachman K.E.
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Papadopoulos N.
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Vogelstein B.
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Kinzler K.W.
,
Velculescu V.E.
more...
Science314:268-274(2006)
[
PubMed ]
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Europe PMC ]
[
Abstract ]
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Cited for : VARIANTS [LARGE SCALE ANALYSIS] GLY-1199 AND GLU-1799
28.
"Patterns of somatic mutation in human cancer genomes."
Greenman C.
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Stephens P.
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Smith R.
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Dalgliesh G.L.
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Hunter C.
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Bignell G.
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Davies H.
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Butler A.
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Stevens C.
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O'Meara S.
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Vastrik I.
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Bhamra G.
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Buck G.
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Cole J.
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Jones D.
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Mironenko T.
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Shepherd R.
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Small A.
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Yates A.
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Louis D.N.
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Goldstraw P.
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Nicholson A.G.
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Brasseur F.
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Looijenga L.
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Weber B.L.
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Chiew Y.-E.
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DeFazio A.
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Greaves M.F.
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Green A.R.
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Campbell P.
,
Birney E.
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Easton D.F.
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Chenevix-Trench G.
,
Tan M.-H.
,
Khoo S.K.
,
Teh B.T.
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Yuen S.T.
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Leung S.Y.
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Wooster R.
,
Futreal P.A.
,
Stratton M.R.
more...
Nature446:153-158(2007)
[
PubMed ]
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Europe PMC ]
[
Abstract ]
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Cited for : VARIANTS [LARGE SCALE ANALYSIS] THR-141; VAL-149; GLN-419; THR-509; GLY-527; ILE-665; ALA-674; ARG-823; VAL-1546; GLU-1799; ILE-1808; LEU-1823; HIS-1957; CYS-2190; LEU-2362 AND TRP-2380