Gene name:
Wnk1 (Hsn2;Prkwnk1) ;
Protein name:
Serine/threonine-protein kinase WNK1 ;
Alternative:
Protein kinase with no lysine 1 ;Protein kinase lysine-deficient 1 ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Interacts with SYT2. Interacts with WNK3 and WNK4.
Function:
Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D and SGK1. Controls sodium and chloride ion transport by inhibiting the activity of WNK4, by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation. WNK1 may also play a role in actin cytoskeletal reorganization. Phosphorylates NEDD4L.
Subcellular Location:
Cytoplasm
Protein Attributes:
50:
MSDGTAEKQS | GTPGFLSPPA | PVPKNGSSSD | SSVGEKLGAA | VADSGIGRTE |
100:
EYRRRRHTMD | KDSRGAAATT | TPTEHRFFRR | SVICDSNATA | LELPGLPLSI |
150:
PQPSVPAVVP | QSAPPEPHRE | ETLTATVASQ | VSQQPSAAAS | PGEQAVVGSA |
200:
TATVPSSTSK | DRPVSQPSLV | GSKEEPPPSR | SGSGSGGASA | KEPQEERNQQ |
250:
QDDIEELETK | AVGMSNDGRF | LKFDIEIGRG | SFKTVYKGLD | TETTVEVAWC |
300:
ELQDRKLTKS | ERQRFKEEAE | MLKGLQHPNI | VRFYDSWEST | VKGKKCIVLV |
350:
TELMTSGTLK | TYLKRFKVMK | IKVLRSWCRQ | ILKGLQFLHT | RTPPIIHRDL |
400:
KCDNIFITGP | TGSVKIGDLG | LATLKRASFA | KSVIGTPEFM | APEMYEEKYD |
450:
ESVDVYAFGM | CMLEMATSEY | PYSECQNAAQ | IYRRVTSGVK | PASFDKVAIP |
500:
EVKEIIEGCI | RQNKDERYSI | KDLLNHAFFQ | EETGVRVELA | EEDDGEKIAI |
550:
KLWLRIEDIK | KLKGKYKDNE | AIEFSFDLER | DVPEDVAQEM | VESGYVCEGD |
600:
HKTMAKAIKD | RVSLIKRKRE | QRQLVREEQE | KRKQEESSFK | QQNEQQASVS |
650:
QAGIQPLSVA | STGIPTAPTT | SASVSTQVEP | EEPEADQHQQ | LQYQQPSISV |
700:
LSDGTVDSGQ | GSSVFTESRV | SSQQTVSYGS | QHEQAHSIGT | APGHTVSSIQ |
750:
AQSQPHGVYP | PSSMAQGQNQ | GQPSSSLAGV | LSSQPVQHPQ | QQGIQPTVPP |
800:
QQAVQYSLPQ | AASSSEGTVQ | PVSQPQVSAG | TQSSTQGVSQ | AAPPEQTPIT |
850:
QSQPTQPVPL | VSSVDSAHSD | VASGMSDGNE | NAPSSSGRHE | GRTTKRHYRK |
900:
SVRSRSRHEK | TSRPKLRILN | VSNKGDRVVE | CQLETHNRKM | VTFKFDLDGD |
950:
NPEEIATIMV | NNDFILAIER | ESFVAQVREI | IEKADEMLSE | DVSVEPEGDQ |
1000:
GLESLQGKDD | YGFPGSQKLE | GEFKQPIAVS | SMPQQIGVPT | SSLTQVVHSA |
1050:
GRRFIVSPVP | ESRLRESKIF | TSEIPDPVAA | STSQGPGMNL | SHSASSLSLQ |
1100:
QAFSELKHGQ | MTEGPNTAPP | NFNHPGPTFS | PFLTSIAGVQ | TVAASTPSVS |
1150:
VPITSSPLND | ISTSVMQSEG | ALPTDKGIGG | VTTSTGVVAS | GGLTTLSVSE |
1200:
TPTLSSAVSS | STAPAVVTVS | TTSQPVQAST | SGSIASSTGS | FPSGTFSTTT |
1250:
GTTVSSVAVP | NAKPPTVLLQ | QVAGNTAGVA | IVTSVSTTTP | FPAMASQPSL |
1300:
PLGSSTSAPT | LAETVVVSAH | SLDKASHSST | AGLGLSFCAP | SSSSSSGTAV |
1350:
SSSVSQPGIV | HPLVISSAIA | STPVLPQPAV | PTSTPLLPQV | PNIPPLVQPV |
1400:
ANVPAVQQTL | IHSQPQPALL | PNQPHTHCPE | MDADTQSKAP | GIDDIKTLEE |
1450:
KLRSLFSEHS | SSGTQHASVS | LETPLVVETV | TPGIPTTAVA | PSKLMTSTTS |
1500:
TCLPPTNLPL | GTAGMPVMPV | GTPGQVSTPG | THASAPASTA | TGAKPGTTPP |
1550:
KPSLTKTVVP | PVGTELSAGT | VPCEQLPPFP | GPSLIQTQQP | LEDLDAQLRR |
1600:
TLSPETIPVT | PAVGPLSTMS | STAVTEAGSQ | PQKDGTEVHV | TASSSGAGVV |
1650:
KMGRFQVSVT | MDDAQKERKN | RSEDTKSVHF | ESSTSESSVL | SSSSPESTLV |
1700:
KPEPNGITVS | GISLDVPDST | HRTPTPEAKS | ETGQPTKVGR | FQVTTTANKV |
1750:
GRFSVSRTED | KVTELKKEGP | VTSPFRDSEQ | TVIPAAIPKK | EKPELAEPSH |
1800:
LNGPSSDLEA | AFLSRGGEDG | SGSPHSPPHL | CSKSLPIQTL | SQSLSNSFNS |
1850:
SYMSSDNESD | IEDEDLRLEL | RRLREKHLKE | IQDLQSRQKH | EIESLYTKLG |
1900:
KVPPAVIIPP | AAPLSGRRRR | PTKSKGSKSS | RSSSLGNKSP | QLSGNLSGQS |
1950:
GTSVLNPQQT | LHPPGNTPET | GHNQLLQPLK | PSPSSDNLYS | AFTSDGAISV |
2000:
PSLSAPGQGT | SSTNTVGGTV | SSQAAQAQPP | AMTSSRKGTF | TDDLHKLVDN |
2050:
WARDAMNLSG | RRGSKGHMNY | EGPGMARKFS | APGQLCISMT | SNMGGSTPIS |
2100:
AASATSLGHF | TKSMCPPQQY | GFPAAPFGTQ | WSGTGGPAPQ | PLGQFQPVGT |
2126:
TSLQNFNISN | LQKSISNPPG | SNLRTT
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Pig
Human
Mouse
Rat
ELISA Kit for Rat Serine/threonine-protein kinase WNK1
ELISA Kit for Rat Serine/threonine-protein kinase WNK1
ELISA Kit for Rat Serine/threonine-protein kinase WNK1
ELISA Kit for Rat Serine/threonine-protein kinase WNK1
CLIA Kit for Rat Serine/threonine-protein kinase WNK1
CLIA Kit for Rat Serine/threonine-protein kinase WNK1
CLIA Kit for Rat Serine/threonine-protein kinase WNK1
CLIA Kit for Rat Serine/threonine-protein kinase WNK1
Polyclonal Antibody for Rat Serine/threonine-protein kinase WNK1
Polyclonal Antibody for Rat Serine/threonine-protein kinase WNK1
Polyclonal Antibody for Rat Serine/threonine-protein kinase WNK1
Polyclonal Antibody for Rat Serine/threonine-protein kinase WNK1
Monoclonal Antibody for Rat Serine/threonine-protein kinase WNK1
Monoclonal Antibody for Rat Serine/threonine-protein kinase WNK1
Monoclonal Antibody for Rat Serine/threonine-protein kinase WNK1
Monoclonal Antibody for Rat Serine/threonine-protein kinase WNK1
Protein for Rat Serine/threonine-protein kinase WNK1
Protein for Rat Serine/threonine-protein kinase WNK1
Protein for Rat Serine/threonine-protein kinase WNK1
Protein for Rat Serine/threonine-protein kinase WNK1
R&D Technical Data
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Precision
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Recovery
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Linearity
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Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 312-2126
strain :
Brown Norway .
3.
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION OF THE HSN2 EXON
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ENZYME REGULATION;PHOSPHORYLATION AT SER-378 AND SER-382;MUTAGENESIS OF LYS-233; CYS-250; SER-378; SER-382; PHE-524 AND PHE-526
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH WNK3 AND WNK4
6.
"Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members."
Heise C.J.
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J. Biol. Chem.285:25161-25167(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 194-483 OF MUTANT ALA-382;SUBUNIT