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Index > Protein center > Wnk2(Gene name) > Mouse
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  • Wnk2 (Gene name),
  • Serine/threonine-protein kinase WNK2 (Protein name ),  WNK2_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Wnk2(Kiaa1760);
    Protein name:
    Serine/threonine-protein kinase WNK2;
    Alternative:
    Protein kinase with no lysine 2;Protein kinase lysine-deficient 2;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Forms a complex with the phosphorylated form of STK39 in the brain.
    Function:
    Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1. WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity.
    Subcellular Location:
    Cytoplasm Cell membrane
    Protein Attributes:
    Sequence length:
    2149
    Sequence:
    50:
    MDGDGGRRDA | PGALMEAGRG | TGSAGMAEPR | ARAARLGPQR | FLRRSVVESD | 
    100:
    QEEPPGLEAA | ETPSAQPPQP | LQRRVLLLCK | TRRLIAERAR | GRPAAPAPAA | 
    150:
    PAAPPGSPSV | PSDPGPERAG | TQEPSPDPTT | ASAAATQVPD | GGPRQEEAPA | 
    200:
    PTQEDAGTTE | AKPEPGRARK | DEPEEEEDDE | DDLKAVATSL | DGRFLKFDIE | 
    250:
    LGRGSFKTVY | KGLDTETWVE | VAWCELQDRK | LTKLERQRFK | EEAEMLKGLQ | 
    300:
    HPNIVRFYDF | WESSAKGKRC | IVLVTELMTS | GTLKTYLKRF | KVMKPKVLRS | 
    350:
    WCRQILKGLL | FLHTRTPPII | HRDLKCDNIF | ITGPTGSVKI | GDLGLATLKR | 
    400:
    ASFAKSVIGT | PEFMAPEMYE | EHYDESVDVY | AFGMCMLEMA | TSEYPYSECQ | 
    450:
    NAAQIYRKVT | CGIKPASFEK | VHDPEIKEII | GECICKNKEE | RYEIKDLLSH | 
    500:
    AFFAEDTGVR | VELAEEDHGR | KSTIALRLWV | EDPKKLKGKP | KDNGAIEFTF | 
    550:
    DLEKETPDEV | AQEMIDSGFF | HESDVKIVAK | SIRDRVALIQ | WRRERIWPAL | 
    600:
    QSQEPKDSGS | PDKARGLPAP | LQVQVTYHAQ | SGQPGQPEPE | EPEADQHLLP | 
    650:
    PTLPASVTSL | ASDSTFDSGQ | GSTVYSDSQS | SQQSMVLSSL | VDTAPTPASC | 
    700:
    VCSPPVSEGP | GLTHSLPTLG | AFQQPATVPG | LSVGPVPPPA | RPPLLQQHFP | 
    750:
    ESSMSFTPVL | PPPSTPVPTG | PSQPAPPVQQ | PLPMAQPPTL | PQVLAPQPMG | 
    800:
    TVQPVPSHLP | PYLAPTSQVV | APAQLKPLQM | PQPPLQPLAQ | VPPQMPQMPV | 
    850:
    VPPITPLTGL | DGLPQTLTDL | PAANVAPVPP | PQYFSPAVIL | PSLTTPLPTS | 
    900:
    PALPMQAVKL | PHPPGTPLAV | PCQTIVPNAP | AAIPLLAVAP | QGVAALSIHP | 
    950:
    AVAQIPAQPV | YPAAFPQMVP | GDIPPSPHHT | VQSLRATPPQ | LASPVPPQPV | 
    1000:
    QPSVIHLPEQ | AAPTAASGTQ | VLLGHPPSYT | ADVAAPVSAV | SLPPAVLSPP | 
    1050:
    LPDTLLPTVP | DLLPKVPSSL | APTVVAASQS | APAQTSSLLL | PTNPPLPTGP | 
    1100:
    AVAGPCPAVQ | LMVEVAQEEQ | VSQDKPPGPP | QSSESFGGSD | VTSGRDLSDS | 
    1150:
    CEGTFGGGRL | EGRTARKHHR | RSTRARSRQE | RASRPRLTIL | NVCNTGDKMV | 
    1200:
    ECQLETHNHK | MVTFKFDLDG | DAPDEIATYM | VEHDFILPAE | RETFIEQMKD | 
    1250:
    VMDKAEDMLS | EDTDADHGSD | TGTSPPHLGT | CGLATGEENR | QSQANAPVYQ | 
    1300:
    QNVLHTGKRW | FIICPVAEHP | ATDTSESSPP | LPLSSLQPEA | SQDPAPYPDQ | 
    1350:
    LSLTDKPSFP | AAQQLLSQAG | SSNPPGGASA | PLAPSSPPVT | TVIPAAPATS | 
    1400:
    TVPESAAGTA | MQAGGPGTHQ | GPASVHETLQ | PLAETRSAQC | TAQPLSTGQG | 
    1450:
    PCTPALEASR | CSTGLGEPIS | TREVSTQGEP | LPASVPEPSP | PTGATQSVPG | 
    1500:
    QPPPPLPITV | GAISLAAPQL | PSPPLGPTAP | PPPPSALESD | GEGPPPRVGF | 
    1550:
    VDNTIKSLDE | KLRTLLYQEH | VPTSSASAGT | PMEASDRDFT | LEPLRGDLPS | 
    1600:
    ALSDKTPSLT | QQTQPSLEKS | ETAPAGWALA | QREQGASSPM | TAESSSSNTL | 
    1650:
    GCDSDAGQVA | SDSSTAPSVP | QDASGSSVPT | HMDPKDQNSS | VPREALAAPM | 
    1700:
    QSGPGSFTVG | SPAQLRGARD | SGSPHKRPGQ | QDNSSPAKTV | GRFSVVSTQD | 
    1750:
    EWTLASPHSL | RYSAPPDVYL | DEIPSSPEVK | LAVRRVQTAS | SIEVGVEEPA | 
    1800:
    SSDSGDERPR | RRSQVQKQSS | LPGTGGVASD | FVKKATAFLH | RSSRAGSLGP | 
    1850:
    ETPSRAGVKV | PTISITSFHS | QSSYISSDND | SEFEDADIKK | ELRSLREKHL | 
    1900:
    KEISELQSQQ | KQEIEALYRR | LGKPLPPNVG | FFHTAPPMGR | RRKTSKSKLK | 
    1950:
    AGKLLNPLVQ | QLKVVASSTG | HLSDSSRGPP | TKDPRGTKAV | QTQQPCSVRA | 
    2000:
    SLSTDICSGL | ASDGGGARGQ | GWTVYHPTSE | RGAYKSSSKP | RARFLSGPVS | 
    2050:
    VSIWSALKRL | CLGKEHSSSL | YDSPGSSTSS | LAPGPEPGPQ | PTLHVQAQVN | 
    2100:
    NSNNKKGTFT | DDLHKLVDEW | TTKTVGAAQV | KPTLNQLKQT | QKLHDMEASG | 
    2149:
    DARATSVPRA | AVGASCLAPA | PGPLSTTATP | GATPALPVPI | PDPESEKPD
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    String:
    KEGG:
    Pfam:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Serine/threonine-protein kinase WNK2
    ELISA Kit for Mouse Serine/threonine-protein kinase WNK2
    CLIA Kit for Mouse Serine/threonine-protein kinase WNK2
    CLIA Kit for Mouse Serine/threonine-protein kinase WNK2
    Polyclonal Antibody for Mouse Serine/threonine-protein kinase WNK2
    Polyclonal Antibody for Mouse Serine/threonine-protein kinase WNK2
    Monoclonal Antibody for Mouse Serine/threonine-protein kinase WNK2
    Monoclonal Antibody for Mouse Serine/threonine-protein kinase WNK2
    Protein for Mouse Serine/threonine-protein kinase WNK2
    Protein for Mouse Serine/threonine-protein kinase WNK2

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    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1506-2149 (ISOFORM 5)
      strain: C57BL/6J.
      tissue: Retina.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 443-2149 (ISOFORM 6);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 801-2149 (ISOFORM 3);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1513-2149 (ISOFORM 4)
      strain: C57BL/6.
      strain: FVB/N.
      tissue: Brain.
      tissue: Salivary gland.
    4. 4.
      "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N. , Kikuno R. , Ohara R. , Inamoto S. , Koseki H. , Hiraoka S. , Saga Y. , Nagase T. , Ohara O. , Koga H.
      DNA Res.10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 761-2149 (ISOFORM 7)
      tissue: Brain.
    5. 5.
      "WNK2 is a novel regulator of essential neuronal cation-chloride cotransporters."
      Rinehart J. , Vazquez N. , Kahle K.T. , Hodson C.A. , Ring A.M. , Gulcicek E.E. , Louvi A. , Bobadilla N.A. , Gamba G. , Lifton R.P.
      J. Biol. Chem.286:30171-30180(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;PHOSPHORYLATION AT SER-1566; SER-1770 AND SER-1797;INTERACTION WITH STK39
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