WNK3 ELISA Kit for Human(Homo sapiens) | EIAab.comWNK3 ELISA Kit for Human(Homo sapiens)

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WNK3 (Gene name),

Serine/threonine-protein kinase WNK3 (Protein name ), WNK3_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

WNK3(KIAA1566;PRKWNK3);

Protein name:

Serine/threonine-protein kinase WNK3;

Alternative:

Protein kinase with no lysine 3;Protein kinase lysine-deficient 3;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with WNK1 and WNK4.

Function:

Isoform 1, isoform 2, isoform 3 and isoform 4 stimulate the activity of SLC12A1, SLC12A2 and SLC12A3 and inhibit the activity of SLC12A4, SLC12A5, SLC12A6 and SLC12A7. According to PubMed:19470686, isoform 1 inhibits the activity of SLC12A3.

Subcellular Location:

Cytoplasm

Protein Attributes:

Sequence length:

1800

Sequence:

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1650:

1700:

1750:

1800:

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q9BYP7

STRING:

9606.ENSP00000346667

UniGene:

Hs.92423

MIM:

300358

Pfam:

PF12202

String:

Q9BYP7

KEGG:

hsa:65267

Uniprot:

Q9BYP7

FOR

ELISA Kit for Human Serine/threonine-protein kinase WNK3

CLIA Kit for Human Serine/threonine-protein kinase WNK3

Polyclonal Antibody for Human Serine/threonine-protein kinase WNK3

Monoclonal Antibody for Human Serine/threonine-protein kinase WNK3

Protein for Human Serine/threonine-protein kinase WNK3

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"WNK kinases, a novel protein kinase subfamily in multi-cellular organisms."
Verissimo F. , Jordan P.
Oncogene20:5562-5569(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);TISSUE SPECIFICITY;CHROMOSOMAL LOCATION
tissue: Brain.
2.

Jordan P.
Submitted (2002-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION TO N-TERMINUS
3.

"Cloning, genomic organization, alternative splicing and expression analysis of the human gene WNK3 (PRKWNK3)."
Holden S. , Cox J. , Raymond F.L.
Gene335:109-119(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
tissue: Brain.
4.

"The DNA sequence of the human X chromosome."
Ross M.T. , Grafham D.V. , Coffey A.J. , Scherer S. , McLay K. , Muzny D. , Platzer M. , Howell G.R. , Burrows C. , Bird C.P. , Frankish A. , Lovell F.L. , Howe K.L. , Ashurst J.L. , Fulton R.S. , Sudbrak R. , Wen G. , Jones M.C. , more...
Nature434:325-337(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T. , Kikuno R. , Nakayama M. , Hirosawa M. , Ohara O.
DNA Res.7:273-281(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 431-1800 (ISOFORM 3)
tissue: Brain.
6.

"WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis."
Rinehart J. , Kahle K.T. , de Los Heros P. , Vazquez N. , Meade P. , Wilson F.H. , Hebert S.C. , Gimenez I. , Gamba G. , Lifton R.P.
Proc. Natl. Acad. Sci. U.S.A.102:16777-16782(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF ASP-294;TISSUE SPECIFICITY
7.

"WNK3 modulates transport of Cl- in and out of cells: implications for control of cell volume and neuronal excitability."
Kahle K.T. , Rinehart J. , de Los Heros P. , Louvi A. , Meade P. , Vazquez N. , Hebert S.C. , Gamba G. , Gimenez I. , Lifton R.P.
Proc. Natl. Acad. Sci. U.S.A.102:16783-16788(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
8.

"WNK3, a kinase related to genes mutated in hereditary hypertension with hyperkalaemia, regulates the K+ channel ROMK1 (Kir1.1)."
Leng Q. , Kahle K.T. , Rinehart J. , MacGregor G.G. , Wilson F.H. , Canessa C.M. , Lifton R.P. , Hebert S.C.
J. Physiol. (Lond.)571:275-286(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
9.

"Protein kinase WNK3 increases cell survival in a caspase-3-dependent pathway."
Verissimo F. , Silva E. , Morris J.D. , Pepperkok R. , Jordan P.
Oncogene25:4172-4182(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
10.

"The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex."
Yang C.L. , Zhu X. , Ellison D.H.
J. Clin. Invest.117:3403-3411(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH WNK1 AND WNK4;ENZYME REGULATION
11.

"WNK3 positively regulates epithelial calcium channels TRPV5 and TRPV6 via a kinase-dependent pathway."
Zhang W. , Na T. , Peng J.B.
Am. J. Physiol.295:F1472-F1484(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
12.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
13.

"Renal and brain isoforms of WNK3 have opposite effects on NCCT expression."
Glover M. , Zuber A.M. , O'Shaughnessy K.M.
J. Am. Soc. Nephrol.20:1314-1322(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ALTERNATIVE SPLICING
14.

"Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members."
Heise C.J. , Xu B.E. , Deaton S.L. , Cha S.K. , Cheng C.J. , Earnest S. , Sengupta S. , Juang Y.C. , Stippec S. , Xu Y. , Zhao Y. , Huang C.L. , Cobb M.H.
J. Biol. Chem.285:25161-25167(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
15.

"Similar Effects of all WNK3 Variants upon SLC12 Cotransporters."
Cruz-Rangel S. , Melo Z. , Vazquez N. , Meade P. , Bobadilla N.A. , Pasantes-Morales H. , Gamba G. , Mercado A.
Am. J. Physiol.301:C601-C608(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ALTERNATIVE SPLICING (ISOFORM 4);MUTAGENESIS OF ASP-294
16.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-62;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
17.

"KLHL2 interacts with and ubiquitinates WNK kinases."
Takahashi D. , Mori T. , Wakabayashi M. , Mori Y. , Susa K. , Zeniya M. , Sohara E. , Rai T. , Sasaki S. , Uchida S.
Biochem. Biophys. Res. Commun.437:457-462(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION BY KLHL2
18.

"Patterns of somatic mutation in human cancer genomes."
Greenman C. , Stephens P. , Smith R. , Dalgliesh G.L. , Hunter C. , Bignell G. , Davies H. , Teague J. , Butler A. , Stevens C. , Edkins S. , O'Meara S. , Vastrik I. , Schmidt E.E. , Avis T. , Barthorpe S. , Bhamra G. , Buck G. , more...
Nature446:153-158(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-704; CYS-854; THR-998; GLU-1169; ILE-1375; PHE-1533 AND PRO-1634

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