Wnk3 ELISA Kit for Mouse(Mus musculus) | EIAab.comWnk3 ELISA Kit for Mouse(Mus musculus)

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Wnk3 (Gene name),

Serine/threonine-protein kinase WNK3 (Protein name ), WNK3_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Wnk3;

Protein name:

Serine/threonine-protein kinase WNK3;

Alternative:

Protein kinase with no lysine 3;Protein kinase lysine-deficient 3;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with WNK1 and WNK4.

Function:

Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A1, SLC12A2, SLC12A3, SCNN1A, SCNN1B, SCNN1D and SGK1. Inhibits SLC12A4, SLC12A5, SLC12A6 and SLC12A7. Phosphorylates WNK4. Increases Ca(2+) influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level via a kinase-dependent pathway. Inhibits KCNJ1 by decreasing its expression at the cell membrane in a non-catalytic manner.

Subcellular Location:

Cytoplasm

Protein Attributes:

Sequence length:

1789

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1789:

QQSVVLPTQS | GGLFQPGMNL | QSFPAPPVQN | PASIPPGPK

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

mmu:279561

String:

Q80XP9

STRING:

10090.ENSMUSP00000094005

UniGene:

Mm.441474

SMR:

Q80XP9

Pfam:

PF12202

Uniprot:

Q80XP9

FOR

ELISA Kit for Mouse Serine/threonine-protein kinase WNK3

CLIA Kit for Mouse Serine/threonine-protein kinase WNK3

Polyclonal Antibody for Mouse Serine/threonine-protein kinase WNK3

Monoclonal Antibody for Mouse Serine/threonine-protein kinase WNK3

Protein for Mouse Serine/threonine-protein kinase WNK3

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Mouse Wnk3 gene encodes multiple continuous open reading frames."
Shmukler B.E. , Alper S.L.
Submitted (2011-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
strain: C57BL/6J.
tissue: Brain.
2.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1296-1757
strain: C57BL/6.
tissue: Embryonic brain.
4.

"Renal and brain isoforms of WNK3 have opposite effects on NCCT expression."
Glover M. , Zuber A.M. , O'Shaughnessy K.M.
J. Am. Soc. Nephrol.20:1314-1322(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ALTERNATIVE SPLICING

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