Wnk4 ELISA Kit for Mouse(Mus musculus) | EIAab.comWnk4 ELISA Kit for Mouse(Mus musculus)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > Wnk4(Gene name) > Mouse

Wnk4 (Gene name),

Serine/threonine-protein kinase WNK4 (Protein name ), WNK4_MOUSE from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

Wnk4(Prkwnk4);

Protein name:

Serine/threonine-protein kinase WNK4;

Alternative:

Protein kinase with no lysine 4;Protein kinase lysine-deficient 4;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with the C-terminal region of KCNJ1. Interacts with WNK1 and WNK3.

Function:

Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6. Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+) channel, KCNJ1, via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 appears to act as a molecular switch that can vary the balance between NaCl reabsorption and K(+) secretion to maintain integrated homeostasis. Phosphorylates NEDD4L.

Subcellular Location:

Cell junction tight junction Present exclusively in intercellular junctions in the distal convoluted tubule and in both the cytoplasm and intercellular junctions in the cortical collecting duct. WNK4 is part of the tight junction complex.

Protein Attributes:

Sequence length:

1222

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

950:

1000:

1050:

1100:

1150:

1200:

1222:

STGSQEQRAS | KGVTFAGDIG | RM

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

String:

Q80UE6

Pfam:

PF12202

SMR:

Q80UE6

UniGene:

Mm.23656

KEGG:

mmu:69847

Uniprot:

Q80UE6

FOR

ELISA Kit for Mouse Serine/threonine-protein kinase WNK4

CLIA Kit for Mouse Serine/threonine-protein kinase WNK4

Polyclonal Antibody for Mouse Serine/threonine-protein kinase WNK4

Monoclonal Antibody for Mouse Serine/threonine-protein kinase WNK4

Protein for Mouse Serine/threonine-protein kinase WNK4

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Molecular pathogenesis of inherited hypertension with hyperkalemia: The Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4."
Wilson F.H. , Kahle K.T. , Sabath E. , Lalioti M.D. , Rapson A.K. , Hoover R.S. , Hebert S.C. , Gamba G. , Lifton R.P.
Proc. Natl. Acad. Sci. U.S.A.100:680-684(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: C57BL/6.
tissue: Kidney.
2.

"WNK kinases regulate thiazide-sensitive Na-Cl cotransport."
Yang C.-L. , Angell J. , Mitchell R. , Ellison D.H.
J. Clin. Invest.111:1039-1045(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;MUTAGENESIS OF GLU-559; ASP-561 AND GLN-562
strain: BALB/c.
3.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: FVB/N.
tissue: Kidney.
tissue: Mammary carcinoma.
5.

"Human hypertension caused by mutations in WNK kinases."
Wilson F.H. , Disse-Nicodeme S. , Choate K.A. , Ishikawa K. , Nelson-Williams C. , Desitter I. , Gunel M. , Milford D.V. , Lipkin G.W. , Achard J.-M. , Feely M.P. , Dussol B. , Berland Y. , Unwin R.J. , Mayan H. , Simon D.B. , Farfel Z. , Jeunemaitre X. , more...
Science293:1107-1112(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY
6.

"WNK4 regulates the balance between renal NaCl reabsorption and K+ secretion."
Kahle K.T. , Wilson F.H. , Leng Q. , Lalioti M.D. , O'Connell A.D. , Dong K. , Rapson A.K. , MacGregor G.G. , Giebisch G. , Hebert S.C. , Lifton R.P.
Nat. Genet.35:372-376(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH KCNJ1;MUTAGENESIS OF ASP-318
7.

"The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex."
Yang C.L. , Zhu X. , Ellison D.H.
J. Clin. Invest.117:3403-3411(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH WNK1 AND WNK3;PHOSPHORYLATION BY WNK1 AND WNK3
8.

"Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension."
Wakabayashi M. , Mori T. , Isobe K. , Sohara E. , Susa K. , Araki Y. , Chiga M. , Kikuchi E. , Nomura N. , Mori Y. , Matsuo H. , Murata T. , Nomura S. , Asano T. , Kawaguchi H. , Nonoyama S. , Rai T. , Sasaki S. , more...
Cell Rep.3:858-868(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF ASP-561
9.

"Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4."
Shibata S. , Zhang J. , Puthumana J. , Stone K.L. , Lifton R.P.
Proc. Natl. Acad. Sci. U.S.A.110:7838-7843(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF GLN-562

Product Feedback Wall

* Email:
*Comments: