Gene name:
Wnt1 (Int-1;Wnt-1) ;
Protein name:
Proto-oncogene Wnt-1 ;
Alternative:
Proto-oncogene Int-1 ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with PORCN. Interacts with RSPO1, RSPO2 and RSPO3. Interacts with WLS.
Function:
Ligand for members of the frizzled family of seven transmembrane receptors. In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling. Probable developmental protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters. Proeminent role in the induction of the mesencephalon and cerebellum. May play a crucial role in the morphogenesis of the neural tube and/or the early stages of CNS development.
Subcellular Location:
Secreted
extracellular space
extracellular matrix
Protein Attributes:
50:
MGLWALLPSW | VSTTLLLALT | ALPAALAANS | SGRWWGIVNI | ASSTNLLTDS |
100:
KSLQLVLEPS | LQLLSRKQRR | LIRQNPGILH | SVSGGLQSAV | RECKWQFRNR |
150:
RWNCPTAPGP | HLFGKIVNRG | CRETAFIFAI | TSAGVTHSVA | RSCSEGSIES |
200:
CTCDYRRRGP | GGPDWHWGGC | SDNIDFGRLF | GREFVDSGEK | GRDLRFLMNL |
250:
HNNEAGRTTV | FSEMRQECKC | HGMSGSCTVR | TCWMRLPTLR | AVGDVLRDRF |
300:
DGASRVLYGN | RGSNRASRAE | LLRLEPEDPA | HKPPSPHDLV | YFEKSPNFCT |
350:
YSGRLGTAGT | AGRACNSSSP | ALDGCELLCC | GRGHRTRTQR | VTERCNCTFH |
370:
WCCHVSCRNC | THTRVLHECL |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Chicken
Mouse
ELISA Kit for Mouse Proto-oncogene Wnt-1
ELISA Kit for Mouse Proto-oncogene Wnt-1
ELISA Kit for Mouse Proto-oncogene Wnt-1
CLIA Kit for Mouse Proto-oncogene Wnt-1
CLIA Kit for Mouse Proto-oncogene Wnt-1
CLIA Kit for Mouse Proto-oncogene Wnt-1
Polyclonal Antibody for Mouse Proto-oncogene Wnt-1
Polyclonal Antibody for Mouse Proto-oncogene Wnt-1
Polyclonal Antibody for Mouse Proto-oncogene Wnt-1
Monoclonal Antibody for Mouse Proto-oncogene Wnt-1
Monoclonal Antibody for Mouse Proto-oncogene Wnt-1
Monoclonal Antibody for Mouse Proto-oncogene Wnt-1
Protein for Mouse Proto-oncogene Wnt-1
Protein for Mouse Proto-oncogene Wnt-1
Protein for Mouse Proto-oncogene Wnt-1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
strain :
C3H .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
Czech II .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : POSSIBLE FUNCTION
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DEVELOPMENTAL STAGE
strain :
CBA/Ca .
tissue :
Embryo .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY
strain :
ICR .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH PORCN
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH RSPO1; RSPO2 AND RSPO3
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH WLS
13.
"Mutations in WNT1 cause different forms of bone fragility."
Keupp K.
,
Beleggia F.
,
Kayserili H.
,
Barnes A.M.
,
Steiner M.
,
Semler O.
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Aglan M.
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Zabel B.
,
Eysel P.
,
Koerber F.
,
Leikin S.
,
Garcia K.C.
,
Netzer C.
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Schoenau E.
,
Ruiz-Perez V.L.
,
Mundlos S.
,
Amling M.
,
Kornak U.
,
Marini J.
,
Wollnik B.
more...
Am. J. Hum. Genet.92:565-574(2013)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY
14.
"WNT1 mutations in early-onset osteoporosis and osteogenesis imperfecta."
Laine C.M.
,
Joeng K.S.
,
Campeau P.M.
,
Kiviranta R.
,
Tarkkonen K.
,
Grover M.
,
Lu J.T.
,
Pekkinen M.
,
Wessman M.
,
Heino T.J.
,
Nieminen-Pihala V.
,
Aronen M.
,
Laine T.
,
Kroeger H.
,
Cole W.G.
,
Lehesjoki A.E.
,
Nevarez L.
,
Krakow D.
,
Curry C.J.
,
Cohn D.H.
,
Gibbs R.A.
,
Lee B.H.
,
Maekitie O.
more...
N. Engl. J. Med.368:1809-1816(2013)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY