Gene name:
Wnt5a (Wnt-5a) ;
Protein name:
Protein Wnt-5a ;
Alternative:
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with PORCN. Interacts with WLS.
Function:
Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes.
Subcellular Location:
Secreted
extracellular space
extracellular matrix
Protein Attributes:
50:
MKKPIGILSP | GVALGTAGGA | MSSKFFLMAL | ATFFSFAQVV | IEANSWWSLG |
100:
MNNPVQMSEV | YIIGAQPLCS | QLAGLSQGQK | KLCHLYQDHM | QYIGEGAKTG |
150:
IKECQYQFRH | RRWNCSTVDN | TSVFGRVMQI | GSRETAFTYA | VSAAGVVNAM |
200:
SRACREGELS | TCGCSRAARP | KDLPRDWLWG | GCGDNIDYGY | RFAKEFVDAR |
250:
ERERIHAKGS | YESARILMNL | HNNEAGRRTV | YNLADVACKC | HGVSGSCSLK |
300:
TCWLQLADFR | KVGDALKEKY | DSAAAMRLNS | RGKLVQVNSR | FNSPTTQDLV |
350:
YIDPSPDYCV | RNESTGSLGT | QGRLCNKTSE | GMDGCELMCC | GRGYDQFKTV |
380:
QTERCHCKFH | WCCYVKCKKC | TEIVDQFVCK |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
Rabbit
ELISA Kit for Mouse Protein Wnt-5a
ELISA Kit for Mouse Protein Wnt-5a
ELISA Kit for Mouse Protein Wnt-5a
ELISA Kit for Mouse Protein Wnt-5a
CLIA Kit for Mouse Protein Wnt-5a
CLIA Kit for Mouse Protein Wnt-5a
CLIA Kit for Mouse Protein Wnt-5a
CLIA Kit for Mouse Protein Wnt-5a
Polyclonal Antibody for Mouse Protein Wnt-5a
Polyclonal Antibody for Mouse Protein Wnt-5a
Polyclonal Antibody for Mouse Protein Wnt-5a
Polyclonal Antibody for Mouse Protein Wnt-5a
Monoclonal Antibody for Mouse Protein Wnt-5a
Monoclonal Antibody for Mouse Protein Wnt-5a
Monoclonal Antibody for Mouse Protein Wnt-5a
Monoclonal Antibody for Mouse Protein Wnt-5a
Protein for Mouse Protein Wnt-5a
Protein for Mouse Protein Wnt-5a
Protein for Mouse Protein Wnt-5a
Protein for Mouse Protein Wnt-5a
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue :
Embryo .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
strain :
C57BL/6J .
tissue :
Testis .
tissue :
Vagina .
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PLoS Biol.7:E1000112-E1000112(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
C57BL/6J .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Mammary tumor .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 62-82;FUNCTION
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;TISSUE SPECIFICITY;DISRUPTION PHENOTYPE
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH PORCN
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;DISRUPTION PHENOTYPE
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;PRELIMINARY CYSTEINE PALMITOYLATION;GLYCOSYLATION AT ASN-114; ASN-120; ASN-312 AND ASN-326;MUTAGENESIS OF CYS-104; ASN-114; ASN-120; ASN-312 AND ASN-326
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH WLS
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Cell149:1565-1577(2012)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEOLYTIC PROCESSING BY TIKI1 AND TIKI2;DISULFIDE BONDS;SUBUNIT