Gene name:
    Wnt5a (Wnt-5a) ;
    
 
    Protein name:
    Protein Wnt-5a ;
    
    Alternative:
    
    
    
 
    Organism:
        
        
        
        
        
        
    
        Mouse  (Mus musculus).  
    
 
General Annotation
    Sub Unit:
    Interacts with PORCN. Interacts with WLS.
    
 
    Function:
    Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes.
    
 
    
        
        Subcellular Location:
        
    
     
     
      Secreted  
      extracellular space  
      extracellular matrix 
     
  
    
 
    
    Protein Attributes:
    
    50:
    MKKPIGILSP |  GVALGTAGGA |  MSSKFFLMAL |  ATFFSFAQVV |  IEANSWWSLG |  
    
 
    100:
    MNNPVQMSEV |  YIIGAQPLCS |  QLAGLSQGQK |  KLCHLYQDHM |  QYIGEGAKTG |  
    
 
    150:
    IKECQYQFRH |  RRWNCSTVDN |  TSVFGRVMQI |  GSRETAFTYA |  VSAAGVVNAM |  
    
 
    200:
    SRACREGELS |  TCGCSRAARP |  KDLPRDWLWG |  GCGDNIDYGY |  RFAKEFVDAR |  
    
 
    250:
    ERERIHAKGS |  YESARILMNL |  HNNEAGRRTV |  YNLADVACKC |  HGVSGSCSLK |  
    
 
    300:
    TCWLQLADFR |  KVGDALKEKY |  DSAAAMRLNS |  RGKLVQVNSR |  FNSPTTQDLV |  
    
 
    350:
    YIDPSPDYCV |  RNESTGSLGT |  QGRLCNKTSE |  GMDGCELMCC |  GRGYDQFKTV |  
    
 
    380:
    QTERCHCKFH |  WCCYVKCKKC |  TEIVDQFVCK |  
    
 
      Vaild Sequence:
    
 
Related Databases
Uniprot:
 
 
    
        
        ELISA Kit
         
        
        CLIA Kit
         
        
        Polyclonal Antibody
         
        
        Monoclonal Antibody
         
        
        Protein
         
        
     
FOR
    
        
        Human
         
        
        Mouse
         
        
        Rat
         
        
        Rabbit
         
        
     
    
        ELISA Kit for Mouse Protein Wnt-5a
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
    
    
    
    
 
    
        ELISA Kit for Mouse Protein Wnt-5a
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
    
    
    
    
 
    
        ELISA Kit for Mouse Protein Wnt-5a
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
    
    
    
    
 
    
        ELISA Kit for Mouse Protein Wnt-5a
        
     
    
    
    
    
    
    
    
    
 
    
        CLIA Kit for Mouse Protein Wnt-5a
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
 
    
        CLIA Kit for Mouse Protein Wnt-5a
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
    
    
    
    
 
    
        CLIA Kit for Mouse Protein Wnt-5a
        
     
    
    
    
    
    
    
    
    
 
    
        CLIA Kit for Mouse Protein Wnt-5a
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Mouse Protein Wnt-5a
        
     
    
    
    
    
   
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Mouse Protein Wnt-5a
        
     
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Mouse Protein Wnt-5a
        
     
    
    
    
    
   
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Mouse Protein Wnt-5a
        
     
    
    
    
    
   
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Mouse Protein Wnt-5a
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Mouse Protein Wnt-5a
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Mouse Protein Wnt-5a
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Mouse Protein Wnt-5a
        
     
    
    
    
    
    
    
 
    
        Protein for Mouse Protein Wnt-5a
        
     
    
    
    
    
    
    
 
    
        Protein for Mouse Protein Wnt-5a
        
     
    
    
    
    
    
    
 
    
        Protein for Mouse Protein Wnt-5a
        
     
    
    
    
    
    
    
 
    
        Protein for Mouse Protein Wnt-5a
        
     
    
    
    
    
    
    
 
 
 
 
 
 
 
 
    R&D Technical Data
    
    
    
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    Precision
    
    
    
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    Recovery
    
    
    
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    Linearity
    
    
    
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    References
    
    
        
            
        
            
                1.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1) 
                    
                    
                    tissue :
                    
Embryo .  
             
         
            
        
            
                2.
                
                    
                        
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Abstract ]
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2) 
                    
                    
                    strain :
                    
C57BL/6J . tissue :
                    
Testis . tissue :
                    
Vagina .  
             
         
            
        
            
                3.
                
                    
                        
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                              more...   
                             
                        
                        
                        
                            PLoS Biol.7:E1000112-E1000112(2009)
                         
                        
                        
                        [
PubMed ]
                        [
Europe PMC ]
                        [
Abstract ]
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] 
                    
                    
                    strain :
                    
C57BL/6J .  
             
         
            
        
            
                4.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1) 
                    
                    
                    tissue :
                    
Mammary tumor .  
             
         
            
        
            
                5.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for PROTEIN SEQUENCE OF 62-82;FUNCTION 
                    
                    
                 
             
         
            
        
            
                6.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for FUNCTION;TISSUE SPECIFICITY;DISRUPTION PHENOTYPE 
                    
                    
                 
             
         
            
        
            
                7.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for INTERACTION WITH PORCN 
                    
                    
                 
             
         
            
        
            
                8.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for FUNCTION;DISRUPTION PHENOTYPE 
                    
                    
                 
             
         
            
        
            
                9.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for FUNCTION;PRELIMINARY CYSTEINE PALMITOYLATION;GLYCOSYLATION AT ASN-114; ASN-120; ASN-312 AND ASN-326;MUTAGENESIS OF CYS-104; ASN-114; ASN-120; ASN-312 AND ASN-326 
                    
                    
                 
             
         
            
        
            
                10.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for INTERACTION WITH WLS 
                    
                    
                 
             
         
            
        
            
                11.
                
                    
                        
                            "Tiki1 is required for head formation via Wnt cleavage-oxidation and inactivation." 
                        
                        
                            Zhang X. 
                        ,
                            
Abreu J.G. 
                        ,
                            
Yokota C. 
                        ,
                            
Macdonald B.T. 
                        ,
                            
Singh S. 
                        ,
                            
Coburn K.L. 
                        ,
                            
Cheong S.M. 
                        ,
                            
Zhang M.M. 
                        ,
                            
Ye Q.Z. 
                        ,
                            
Hang H.C. 
                        ,
                            
Steen H. 
                        ,
                            
He X. 
                        
                        
                        
                        
                            Cell149:1565-1577(2012)
                         
                        
                        
                        [
PubMed ]
                        [
Europe PMC ]
                        [
Abstract ]
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for PROTEOLYTIC PROCESSING BY TIKI1 AND TIKI2;DISULFIDE BONDS;SUBUNIT