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Index > Protein center > Wnt5a(Gene name) > Mouse
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  • Wnt5a (Gene name),
  • Protein Wnt-5a (Protein name ),  WNT5A_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Wnt5a(Wnt-5a);
    Protein name:
    Protein Wnt-5a;
    Alternative:

    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with PORCN. Interacts with WLS.
    Function:
    Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes.
    Subcellular Location:
    Secreted extracellular space extracellular matrix
    Protein Attributes:
    Sequence length:
    380
    Sequence:
    50:
    MKKPIGILSP | GVALGTAGGA | MSSKFFLMAL | ATFFSFAQVV | IEANSWWSLG | 
    100:
    MNNPVQMSEV | YIIGAQPLCS | QLAGLSQGQK | KLCHLYQDHM | QYIGEGAKTG | 
    150:
    IKECQYQFRH | RRWNCSTVDN | TSVFGRVMQI | GSRETAFTYA | VSAAGVVNAM | 
    200:
    SRACREGELS | TCGCSRAARP | KDLPRDWLWG | GCGDNIDYGY | RFAKEFVDAR | 
    250:
    ERERIHAKGS | YESARILMNL | HNNEAGRRTV | YNLADVACKC | HGVSGSCSLK | 
    300:
    TCWLQLADFR | KVGDALKEKY | DSAAAMRLNS | RGKLVQVNSR | FNSPTTQDLV | 
    350:
    YIDPSPDYCV | RNESTGSLGT | QGRLCNKTSE | GMDGCELMCC | GRGYDQFKTV | 
    380:
    QTERCHCKFH | WCCYVKCKKC | TEIVDQFVCK | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    String:
    KEGG:
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Protein Wnt-5a
    Cat.:
    E1038h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Mouse Protein Wnt-5a
    Cat.:
    E1038m
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Mouse Protein Wnt-5a
    Cat.:
    E1038r
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    MSDS:
    Please sign in first.
    Packing:
    96T
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    ELISA Kit for Mouse Protein Wnt-5a
    MSDS:
    Please sign in first.
    CLIA Kit for Mouse Protein Wnt-5a
    Cat.:
    U1038r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Protein Wnt-5a
    Cat.:
    U1038m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse Protein Wnt-5a
    MSDS:
    Please sign in first.
    CLIA Kit for Mouse Protein Wnt-5a
    Cat.:
    U1038h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Mouse Protein Wnt-5a
    Cat.:
    P1038Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Protein Wnt-5a
    Polyclonal Antibody for Mouse Protein Wnt-5a
    Cat.:
    P1038Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Protein Wnt-5a
    Cat.:
    P1038Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Protein Wnt-5a
    Monoclonal Antibody for Mouse Protein Wnt-5a
    Monoclonal Antibody for Mouse Protein Wnt-5a
    Monoclonal Antibody for Mouse Protein Wnt-5a
    Protein for Mouse Protein Wnt-5a
    Protein for Mouse Protein Wnt-5a
    Protein for Mouse Protein Wnt-5a
    Protein for Mouse Protein Wnt-5a

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    Linearity
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    References
    1. 1.
      "Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development."
      Gavin B.J. , McMahon J.A. , McMahon A.P.
      Genes Dev.4:2319-2332(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Embryo.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      strain: C57BL/6J.
      tissue: Testis.
      tissue: Vagina.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Mammary tumor.
    5. 5.
      "Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context."
      Mikels A.J. , Nusse R.
      PLoS Biol.4:E115-E115(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 62-82;FUNCTION
    6. 6.
      "A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo."
      Yamaguchi T.P. , Bradley A. , McMahon A.P. , Jones S.
      Development126:1211-1223(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;DISRUPTION PHENOTYPE
    7. 7.
      "The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family."
      Tanaka K. , Okabayashi H. , Asashima M. , Perrimon N. , Kadowaki T.
      Eur. J. Biochem.267:4300-4311(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PORCN
    8. 8.
      "Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation."
      Topol L. , Jiang X. , Choi H. , Garrett-Beal L. , Carolan P.J. , Yang Y.
      J. Cell Biol.162:899-908(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
    9. 9.
      "Post-translational palmitoylation and glycosylation of Wnt-5a are necessary for its signalling."
      Kurayoshi M. , Yamamoto H. , Izumi S. , Kikuchi A.
      Biochem. J.402:515-523(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PRELIMINARY CYSTEINE PALMITOYLATION;GLYCOSYLATION AT ASN-114; ASN-120; ASN-312 AND ASN-326;MUTAGENESIS OF CYS-104; ASN-114; ASN-120; ASN-312 AND ASN-326
    10. 10.
      "Reciprocal regulation of Wnt and Gpr177/mouse Wntless is required for embryonic axis formation."
      Fu J. , Jiang M. , Mirando A.J. , Yu H.-M. , Hsu W.
      Proc. Natl. Acad. Sci. U.S.A.106:18598-18603(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH WLS
    11. 11.
      "Tiki1 is required for head formation via Wnt cleavage-oxidation and inactivation."
      Zhang X. , Abreu J.G. , Yokota C. , Macdonald B.T. , Singh S. , Coburn K.L. , Cheong S.M. , Zhang M.M. , Ye Q.Z. , Hang H.C. , Steen H. , He X.
      Cell149:1565-1577(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC PROCESSING BY TIKI1 AND TIKI2;DISULFIDE BONDS;SUBUNIT
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