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Index > Protein center > Wnt5a(Gene name) > Rat
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  • Wnt5a (Gene name),
  • Protein Wnt-5a (Protein name ),  WNT5A_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Wnt5a(Wnt-5a);
    Protein name:
    Protein Wnt-5a;
    Alternative:

    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Interacts with PORCN (By similarity). Interacts with WLS.
    Function:
    Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes.
    Subcellular Location:
    Secreted extracellular space extracellular matrix
    Protein Attributes:
    Sequence length:
    380
    Sequence:
    50:
    MKKPIGILSP | GVALGTAGGA | MSSKFFLMAL | ATFFSFAQVV | IEANSWWSLG | 
    100:
    MNNPVQMSEV | HIIGAQPLCS | QLAGLSQGQK | KLCHLYQDHM | QYIGEGAKTG | 
    150:
    IKECQYQFRH | RRWNCSTVDN | TSVFGRVMQI | GSRETAFTYA | VSAAGVVNAM | 
    200:
    SRACREGELS | TCGCSRAARP | KDLPRDWLWG | GCGDNIDYGY | RFAKEFVDAR | 
    250:
    ERERIHAKGS | YESARILMNL | HNNEAGRRTV | YNLADVACKC | HGVSGSCSLK | 
    300:
    TCWLQLADFR | KVGDALKEKY | DSAAAMRLNS | RGKLVQVNSR | FNSPTTQDLV | 
    350:
    YIDPSPDYCV | RNESTGSLGT | QGRLCNKTSE | GMDGCELMCC | GRGYDQFKTV | 
    380:
    QTERCHCKFH | WCCYVKCKKC | TEIVDQFVCK | 
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    UniGene:
    KEGG:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Protein Wnt-5a
    Cat.:
    E1038h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Rat Protein Wnt-5a
    Cat.:
    E1038m
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    Please sign in first.
    MSDS:
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    Packing:
    96T
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    ELISA Kit for Rat Protein Wnt-5a
    Cat.:
    E1038r
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Rat Protein Wnt-5a
    MSDS:
    Please sign in first.
    CLIA Kit for Rat Protein Wnt-5a
    Cat.:
    U1038r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Protein Wnt-5a
    Cat.:
    U1038m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Rat Protein Wnt-5a
    MSDS:
    Please sign in first.
    CLIA Kit for Rat Protein Wnt-5a
    Cat.:
    U1038h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Rat Protein Wnt-5a
    Cat.:
    P1038Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Protein Wnt-5a
    Polyclonal Antibody for Rat Protein Wnt-5a
    Cat.:
    P1038Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Protein Wnt-5a
    Cat.:
    P1038Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Rat Protein Wnt-5a
    Monoclonal Antibody for Rat Protein Wnt-5a
    Monoclonal Antibody for Rat Protein Wnt-5a
    Monoclonal Antibody for Rat Protein Wnt-5a
    Protein for Rat Protein Wnt-5a
    Protein for Rat Protein Wnt-5a
    Protein for Rat Protein Wnt-5a
    Protein for Rat Protein Wnt-5a

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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: Sprague-Dawley.
    2. 2.
      "Coexpression of Wnt-5a, Wnt-4, frizzled-4, and DDC4 (frpAP, a secreted Frizzled, AF012891) in the pregnant ovary."
      Lacher M.D. , Walther P.R. , Lareu R.R. , Dharmarajan A.M. , Friis R.R.
      Submitted (1999-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: Sprague-Dawley.
      tissue: Corpus luteum.
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