Protein name:
ATPase WRNIP1 ;
Alternative:
Werner helicase-interacting protein 1 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Homooligomer; most likely an octamer. Interacts with POLD1, POLD2 and POLD4. Interacts with the N-terminal domain of WRN. Interacts (via UBZ-type zinc finger) with polyubiquitin.
Function:
Functions as a modulator for initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. Has an intrinsic ATPase activity that functions as a sensor of DNA damage or of arrested replication forks and regulates the extent of DNA synthesis.
Subcellular Location:
Nucleus
Colocalizes with WRN in granular structures in the nucleus.
Protein Attributes:
50:
MEVSGPEDDP | FLSQLHQVQC | PVCQQMMPAA | HINSHLDRCL | LLHPAGHAEP |
100:
AAGSHRAGER | AKGPSPPGAK | RRRLSESSAL | KQPATPTAAE | SSEGEGEEGD |
150:
DGGETESRES | YDAPPTPSGA | RLIPDFPVAR | SSSPGRKGSG | KRPAAAAAAG |
200:
SASPRSWDEA | EAQEEEEAVG | DGDGDGDADA | DGEDDPGHWD | ADAAEAATAF |
250:
GASGGGRPHP | RALAAEEIRQ | MLQGKPLADT | MRPDTLQDYF | GQSKAVGQDT |
300:
LLRSLLETNE | IPSLILWGPP | GCGKTTLAHI | IASNSKKHSI | RFVTLSATNA |
350:
KTNDVRDVIK | QAQNEKSFFK | RKTILFIDEI | HRFNKSQQDT | FLPHVECGTI |
400:
TLIGATTENP | SFQVNAALLS | RCRVIVLEKL | PVEAMVTILM | RAINSLGIHV |
450:
LDSSRPTDPL | SHSSNSSSEP | AMFIEDKAVD | TLAYLSDGDA | RAGLNGLQLA |
500:
VLARLSSRKM | FCKKSGQSYS | PSRVLITEND | VKEGLQRSHI | LYDRAGEEHY |
550:
NCISALHKSM | RGSDQNASLY | WLARMLEGGE | DPLYVARRLV | RFASEDIGLA |
600:
DPSALTQAVA | AYQGCHFIGM | PECEVLLAQC | VVYFARAPKS | IEVYSAYNNV |
650:
KACLRNHQGP | LPPVPLHLRN | APTRLMKDLG | YGKGYKYNPM | YSEPVDQEYL |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
Mouse
ELISA Kit for Human ATPase WRNIP1
ELISA Kit for Human ATPase WRNIP1
ELISA Kit for Human ATPase WRNIP1
CLIA Kit for Human ATPase WRNIP1
CLIA Kit for Human ATPase WRNIP1
CLIA Kit for Human ATPase WRNIP1
Polyclonal Antibody for Human ATPase WRNIP1
Polyclonal Antibody for Human ATPase WRNIP1
Polyclonal Antibody for Human ATPase WRNIP1
Monoclonal Antibody for Human ATPase WRNIP1
Monoclonal Antibody for Human ATPase WRNIP1
Monoclonal Antibody for Human ATPase WRNIP1
Protein for Human ATPase WRNIP1
Protein for Human ATPase WRNIP1
Protein for Human ATPase WRNIP1
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
tissue :
Cervix carcinoma .
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Nat. Genet.36:40-45(2004)
[
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[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 303-665 (ISOFORM 1)
tissue :
Kidney epithelium .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Brain .
tissue :
Kidney .
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
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more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue :
Muscle .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 144-665 (ISOFORM 1)
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBUNIT;INTERACTION WITH POLD1; POLD2 AND POLD4
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-534 AND TYR-562;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUMOYLATION;UBIQUITINATION AT LYS-81; LYS-141; LYS-225; LYS-301; LYS-310; LYS-316; LYS-322; LYS-335; LYS-482; LYS-627; LYS-633 AND LYS-636;DOMAIN UBZ-TYPE ZINC-FINGER
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-75; THR-85; SER-91; SER-92 AND THR-116;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-85; SER-91 AND SER-92;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Leukemic T-cell .
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-633;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
18.
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Cox J.
,
Jensen T.S.
,
Nigg E.A.
,
Brunak S.
,
Mann M.
Sci. Signal.3:RA3-RA3(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-75 AND SER-153;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
19.
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Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-153;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]