Protein name:
NEDD4-like E3 ubiquitin-protein ligase WWP1 ;
Alternative:
WW domain-containing protein 1 ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Binds SCNN1A, SCNN1B, SCNN1G, WBP1, WBP2, DRPLA and adenovirus type 2 PIII (By similarity). Binds KLF2 AND HIVEP3. Interacts with RNF11. Interacts with SPG20. Interacts with NDFIP1 and NDFIP2; this interaction activates the E3 ubiquitin-protein ligase (By similarity). Interacts with ERBB4 isoforms JM-B CYT-1 and JM-A CYT-1. Does not interact with ERB4 isoform JMA-A CYT-2. Interacts with SMAD1, SMAD2, SMAD3, SMAD5, SMAD6, SMAD7, TGFBR1 AND TGFBR2. Associates with the TGFBR1:TGFBR2 receptor complex in presence of SMAD7. Interacts with SKIL isoform 1. Interacts with TP63 isoform 1 and isoform 2.
Function:
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7.
Subcellular Location:
Cytoplasm
Cell membrane
Peripheral membrane protein
Nucleus
Protein Attributes:
50:
MATASPRSDT | SDIHSGRLQL | KVTVSSAKLK | RKKNWFGTAI | YTEVIVDGEV |
100:
KKTAKSSSSS | NPKWDEQLIV | NVTPQTTLEF | RVWSHHTLKA | DALLGKATVD |
150:
LKQVLLTHNR | KLEKVKEQLK | LSLENKNGIV | QTGELTVVLD | GLVIEQEPVT |
200:
NRSSSPPIEI | QQNGDALHEN | GDPATRTTPR | LPVEGTIGID | NHVSTNTVVP |
250:
NSCCSHVVNG | ENTPSSPSQV | AARPKNAPAP | KPVTSAPTSD | TVNGESSSVL |
300:
ADNTSTMGTL | LPSEDTTSTS | NCTSTTTQEP | PVQEPPASSE | HSECIPSASA |
350:
EVGPEARSLI | DPDSDSRNNS | VFDKVRQPEG | CVEPLRPQSG | NTNTEALPSG |
400:
WEQRKDPHGR | TYYVDHNTRT | TTWERPQPLP | PGWERRVDDR | GRVYYVDHNT |
450:
RTTTWQRPTM | ESVRNFEQWQ | SQRNQLQGAM | QQFNQRYLYS | ASMLAAENDP |
500:
YGPLPPGWEK | RVDSTDRVYF | VNHNTKTTQW | EDPRTQGLPN | EEPLPEGWEI |
550:
RYTREGVRYF | VDHNTRTTTF | KDPRNGKSSV | TKGGPQIAYE | RSFRWKLAHF |
600:
RYLCQSNALP | SHVKINVSRQ | TLFEDSFQQI | MALKPYDLRR | RLYVIFRGEE |
650:
GLDYGGLARE | WFFLLSHEVL | NPMYCLFEYA | GKNNYCLQIN | PASTINPDHL |
700:
SYFCFIGRFI | AMALFHGKFI | DTGFSLPFYK | RMLSKKLTIK | DLESIDTEFY |
750:
NSLIWIRDNN | IEECGLEMYF | SVDMEILGKV | TSHDLKLGGS | NILVTEENKD |
800:
EYIGLMTEWR | FSRGVQEQTK | AFLDGFNEVV | PLQWLQYFDE | KELEVMLCGM |
850:
QEVDLADWQR | NTVYRHYTRN | SKQIIWFWQF | VKETDNEVRM | RLLQFVTGTC |
900:
RLPLGGFAEL | MGSNGPQKFC | IEKVGKDTWL | PRSHTCFNRL | DLPPYKSYEQ |
918:
LKEKLLFAIE | ETEGFGQE
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Mouse NEDD4-like E3 ubiquitin-protein ligase WWP1
ELISA Kit for Mouse NEDD4-like E3 ubiquitin-protein ligase WWP1
CLIA Kit for Mouse NEDD4-like E3 ubiquitin-protein ligase WWP1
CLIA Kit for Mouse NEDD4-like E3 ubiquitin-protein ligase WWP1
Polyclonal Antibody for Mouse NEDD4-like E3 ubiquitin-protein ligase WWP1
Polyclonal Antibody for Mouse NEDD4-like E3 ubiquitin-protein ligase WWP1
Monoclonal Antibody for Mouse NEDD4-like E3 ubiquitin-protein ligase WWP1
Monoclonal Antibody for Mouse NEDD4-like E3 ubiquitin-protein ligase WWP1
Protein for Mouse NEDD4-like E3 ubiquitin-protein ligase WWP1
Protein for Mouse NEDD4-like E3 ubiquitin-protein ligase WWP1
R&D Technical Data
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Precision
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Recovery
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Linearity
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6J .
tissue :
Testis .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 639-918
strain :
FVB/N .
tissue :
Colon .
tissue :
Mammary cancer .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH KLF2
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN UBIQUITINATION OF KLF2;MUTAGENESIS OF CYS-886
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN UBIQUITINATION OF KLF5;INTERACTION WITH KLF5;SUBCELLULAR LOCATION;MUTAGENESIS OF CYS-886
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH HIVEP3
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN UBIQUITINATION OF TP63;INTERACTION WITH TP63
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN UBIQUITINATION OF RNF11;INTERACTION WITH RNF11;UBIQUITINATION;MUTAGENESIS OF CYS-886
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN UBIQUITINATION OF ERBB4;INTERACTION WITH ERBB4