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Index > Protein center > Wwp1(Gene name) > Mouse
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  • Wwp1 (Gene name),
  • NEDD4-like E3 ubiquitin-protein ligase WWP1 (Protein name ),  WWP1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Wwp1;
    Protein name:
    NEDD4-like E3 ubiquitin-protein ligase WWP1;
    Alternative:
    WW domain-containing protein 1;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Binds SCNN1A, SCNN1B, SCNN1G, WBP1, WBP2, DRPLA and adenovirus type 2 PIII (By similarity). Binds KLF2 AND HIVEP3. Interacts with RNF11. Interacts with SPG20. Interacts with NDFIP1 and NDFIP2; this interaction activates the E3 ubiquitin-protein ligase (By similarity). Interacts with ERBB4 isoforms JM-B CYT-1 and JM-A CYT-1. Does not interact with ERB4 isoform JMA-A CYT-2. Interacts with SMAD1, SMAD2, SMAD3, SMAD5, SMAD6, SMAD7, TGFBR1 AND TGFBR2. Associates with the TGFBR1:TGFBR2 receptor complex in presence of SMAD7. Interacts with SKIL isoform 1. Interacts with TP63 isoform 1 and isoform 2.
    Function:
    E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7.
    Subcellular Location:
    Cytoplasm Cell membrane Peripheral membrane protein Nucleus
    Protein Attributes:
    Sequence length:
    918
    Sequence:
    50:
    MATASPRSDT | SDIHSGRLQL | KVTVSSAKLK | RKKNWFGTAI | YTEVIVDGEV | 
    100:
    KKTAKSSSSS | NPKWDEQLIV | NVTPQTTLEF | RVWSHHTLKA | DALLGKATVD | 
    150:
    LKQVLLTHNR | KLEKVKEQLK | LSLENKNGIV | QTGELTVVLD | GLVIEQEPVT | 
    200:
    NRSSSPPIEI | QQNGDALHEN | GDPATRTTPR | LPVEGTIGID | NHVSTNTVVP | 
    250:
    NSCCSHVVNG | ENTPSSPSQV | AARPKNAPAP | KPVTSAPTSD | TVNGESSSVL | 
    300:
    ADNTSTMGTL | LPSEDTTSTS | NCTSTTTQEP | PVQEPPASSE | HSECIPSASA | 
    350:
    EVGPEARSLI | DPDSDSRNNS | VFDKVRQPEG | CVEPLRPQSG | NTNTEALPSG | 
    400:
    WEQRKDPHGR | TYYVDHNTRT | TTWERPQPLP | PGWERRVDDR | GRVYYVDHNT | 
    450:
    RTTTWQRPTM | ESVRNFEQWQ | SQRNQLQGAM | QQFNQRYLYS | ASMLAAENDP | 
    500:
    YGPLPPGWEK | RVDSTDRVYF | VNHNTKTTQW | EDPRTQGLPN | EEPLPEGWEI | 
    550:
    RYTREGVRYF | VDHNTRTTTF | KDPRNGKSSV | TKGGPQIAYE | RSFRWKLAHF | 
    600:
    RYLCQSNALP | SHVKINVSRQ | TLFEDSFQQI | MALKPYDLRR | RLYVIFRGEE | 
    650:
    GLDYGGLARE | WFFLLSHEVL | NPMYCLFEYA | GKNNYCLQIN | PASTINPDHL | 
    700:
    SYFCFIGRFI | AMALFHGKFI | DTGFSLPFYK | RMLSKKLTIK | DLESIDTEFY | 
    750:
    NSLIWIRDNN | IEECGLEMYF | SVDMEILGKV | TSHDLKLGGS | NILVTEENKD | 
    800:
    EYIGLMTEWR | FSRGVQEQTK | AFLDGFNEVV | PLQWLQYFDE | KELEVMLCGM | 
    850:
    QEVDLADWQR | NTVYRHYTRN | SKQIIWFWQF | VKETDNEVRM | RLLQFVTGTC | 
    900:
    RLPLGGFAEL | MGSNGPQKFC | IEKVGKDTWL | PRSHTCFNRL | DLPPYKSYEQ | 
    918:
    LKEKLLFAIE | ETEGFGQE
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    UniGene:
    UniGene:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse NEDD4-like E3 ubiquitin-protein ligase WWP1
    ELISA Kit for Mouse NEDD4-like E3 ubiquitin-protein ligase WWP1
    CLIA Kit for Mouse NEDD4-like E3 ubiquitin-protein ligase WWP1
    CLIA Kit for Mouse NEDD4-like E3 ubiquitin-protein ligase WWP1
    Polyclonal Antibody for Mouse NEDD4-like E3 ubiquitin-protein ligase WWP1
    Polyclonal Antibody for Mouse NEDD4-like E3 ubiquitin-protein ligase WWP1
    Monoclonal Antibody for Mouse NEDD4-like E3 ubiquitin-protein ligase WWP1
    Monoclonal Antibody for Mouse NEDD4-like E3 ubiquitin-protein ligase WWP1
    Protein for Mouse NEDD4-like E3 ubiquitin-protein ligase WWP1
    Protein for Mouse NEDD4-like E3 ubiquitin-protein ligase WWP1

    R&D Technical Data
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Testis.
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 639-918
      strain: FVB/N.
      tissue: Colon.
      tissue: Mammary cancer.
    3. 3.
      "Lung Krueppel-like factor contains an autoinhibitory domain that regulates its transcriptional activation by binding WWP1, an E3 ubiquitin ligase."
      Conkright M.D. , Wani M.A. , Lingrel J.B.
      J. Biol. Chem.276:29299-29306(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KLF2
    4. 4.
      "WWP1-dependent ubiquitination and degradation of the lung Kruppel-like factor, KLF2."
      Zhang X. , Srinivasan S.V. , Lingrel J.B.
      Biochem. Biophys. Res. Commun.316:139-148(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN UBIQUITINATION OF KLF2;MUTAGENESIS OF CYS-886
    5. 5.
      "Ubiquitin-proteasome degradation of KLF5 transcription factor in cancer and untransformed epithelial cells."
      Chen C. , Sun X. , Ran Q. , Wilkinson K.D. , Murphy T.J. , Simons J.W. , Dong J.T.
      Oncogene24:3319-3327(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN UBIQUITINATION OF KLF5;INTERACTION WITH KLF5;SUBCELLULAR LOCATION;MUTAGENESIS OF CYS-886
    6. 6.
      "Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3."
      Jones D.C. , Wein M.N. , Oukka M. , Hofstaetter J.G. , Glimcher M.J. , Glimcher L.H.
      Science312:1223-1227(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HIVEP3
    7. 7.
      "WW domain-containing E3 ubiquitin protein ligase 1 targets p63 transcription factor for ubiquitin-mediated proteasomal degradation and regulates apoptosis."
      Li Y. , Zhou Z. , Chen C.
      Cell Death Differ.15:1941-1951(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN UBIQUITINATION OF TP63;INTERACTION WITH TP63
    8. 8.
      "The WW domain containing E3 ubiquitin protein ligase 1 upregulates ErbB2 and EGFR through RING finger protein 11."
      Chen C. , Zhou Z. , Liu R. , Li Y. , Azmi P.B. , Seth A.K.
      Oncogene27:6845-6855(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN UBIQUITINATION OF RNF11;INTERACTION WITH RNF11;UBIQUITINATION;MUTAGENESIS OF CYS-886
    9. 9.
      "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M. , English L. , Lemieux S. , Courcelles M. , Desjardins M. , Thibault P.
      Immunity30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    10. 10.
      "WW domain containing E3 ubiquitin protein ligase 1 targets the full-length ErbB4 for ubiquitin-mediated degradation in breast cancer."
      Li Y. , Zhou Z. , Alimandi M. , Chen C.
      Oncogene28:2948-2958(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN UBIQUITINATION OF ERBB4;INTERACTION WITH ERBB4
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