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Index > Protein center > Wwp2(Gene name) > Mouse
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  • Wwp2 (Gene name),
  • NEDD4-like E3 ubiquitin-protein ligase WWP2 (Protein name ),  WWP2_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Wwp2;
    Protein name:
    NEDD4-like E3 ubiquitin-protein ligase WWP2;
    Alternative:
    WW domain-containing protein 2;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with SCNN1A, SCNN1B, SCNN1G, WBP1, WBP2 and ATN1. Interacts with ERBB4, NDFIP1 and NDFIP2 (By similarity). Interacts with POU5F1, RBP1, EGR2 and SLC11A2.
    Function:
    E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; regulates POU5F1 protein level during differentiation of embryonal carcinoma cells (ECCs) but not in undifferentiated ECCs and embryonic stem cells (ESCs). Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    870
    Sequence:
    50:
    MASASSSRAG | VALPFEKSQL | TLKVVSAKPK | VHNRQPRINS | YVEVAVDGLP | 
    100:
    SETKKTGKRI | GSSELLWNEI | IVLNVTAQSH | LDLKVWSCHT | LRNELLGTAS | 
    150:
    VNLSNVLKNN | GGKMENTQLT | LNLQTENKGS | VVSGGELTIF | LDGPTVDLGS | 
    200:
    VPNGSAVTDG | SQPPSRESSG | TAIAPETRHQ | PPSTNCFGGR | SRTHRHSGGS | 
    250:
    ARTATAASEQ | SPGARNRHRQ | PVKNSSSSGL | ANGTVNEEPT | PASEPEESSV | 
    300:
    VGVTSLPAAA | LSVSSNPNTT | SLPAQSTPAE | GEEASTSGTQ | QLPAAAQAPD | 
    350:
    ALPAGWEQRE | LPNGRVYYVD | HNTKTTTWER | PLPPGWEKRT | DPRGRFYYVD | 
    400:
    HNTRTTTWQR | PTAEYVRNYE | QWQSQRNQLQ | GAMQHFSQRF | LYQSSSASTD | 
    450:
    HDPLGPLPPG | WEKRQDNGRV | YYVNHNTRTT | QWEDPRTQGM | IQEPALPPGW | 
    500:
    EMKYTSEGVR | YFVDHNTRTT | TFKDPRPGFE | SGTKQGSPGA | YDRSFRWKYH | 
    550:
    QFRFLCHSNA | LPSHVKISVS | RQTLFEDSFQ | QIMNMKPYDL | RRRLYIIMRG | 
    600:
    EEGLDYGGIA | REWFFLLSHE | VLNPMYCLFE | YAGKNNYCLQ | INPASSINPD | 
    650:
    HLTYFRFIGR | FIAMALYHGK | FIDTGFTLPF | YKRMLNKRPT | LKDLESIDPE | 
    700:
    FYNSIVWIKE | NNLEECGLEL | FFIQDMEILG | KVTTHELKEG | GENIRVTEEN | 
    750:
    KEEYIMLLTD | WRFTRGVEEQ | TKAFLDGFNE | VAPLEWLRYF | DEKELELMLC | 
    800:
    GMQEIDMSDW | QKNAIYRHYT | KSSKQIQWFW | QVVKEMDNEK | RIRLLQFVTG | 
    850:
    TCRLPVGGFA | ELIGSNGPQK | FCIDRVGKET | WLPRSHTCFN | RLDLPPYKSY | 
    870:
    EQLKEKLLYA | IEETEGFGQE | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    UniGene:
    Pfam:
    SMR:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse NEDD4-like E3 ubiquitin-protein ligase WWP2
    ELISA Kit for Mouse NEDD4-like E3 ubiquitin-protein ligase WWP2
    CLIA Kit for Mouse NEDD4-like E3 ubiquitin-protein ligase WWP2
    CLIA Kit for Mouse NEDD4-like E3 ubiquitin-protein ligase WWP2
    Polyclonal Antibody for Mouse NEDD4-like E3 ubiquitin-protein ligase WWP2
    Polyclonal Antibody for Mouse NEDD4-like E3 ubiquitin-protein ligase WWP2
    Monoclonal Antibody for Mouse NEDD4-like E3 ubiquitin-protein ligase WWP2
    Monoclonal Antibody for Mouse NEDD4-like E3 ubiquitin-protein ligase WWP2
    Protein for Mouse NEDD4-like E3 ubiquitin-protein ligase WWP2
    Protein for Mouse NEDD4-like E3 ubiquitin-protein ligase WWP2

    R&D Technical Data
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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      strain: NOD.
      tissue: Brain.
      tissue: Liver.
      tissue: Thymus.
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6.
      strain: FVB/N.
      tissue: Brain.
      tissue: Mammary tumor.
    3. 3.
      "Wwp2-mediated ubiquitination of the RNA polymerase II large subunit in mouse embryonic pluripotent stem cells."
      Li H. , Zhang Z. , Wang B. , Zhang J. , Zhao Y. , Jin Y.
      Mol. Cell. Biol.27:5296-5305(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN UBIQUITINATION OF RPB1;INTERACTION WITH RBP1
    4. 4.
      "Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2."
      Foot N.J. , Dalton H.E. , Shearwin-Whyatt L.M. , Dorstyn L. , Tan S.S. , Yang B. , Kumar S.
      Blood112:4268-4275(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN UBIQUITINATION OF SLC11A2;INTERACTION WITH SLC11A2
    5. 5.
      "The HECT-type E3 ubiquitin ligase AIP2 inhibits activation-induced T-cell death by catalyzing EGR2 ubiquitination."
      Chen A. , Gao B. , Zhang J. , McEwen T. , Ye S.Q. , Zhang D. , Fang D.
      Mol. Cell. Biol.29:5348-5356(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN UBIQUITINATION OF EGR2;INTERACTION WITH EGR2
    6. 6.
      "Wwp2 mediates Oct4 ubiquitination and its own auto-ubiquitination in a dosage-dependent manner."
      Liao B. , Jin Y.
      Cell Res.20:332-344(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN UBIQUITINATION OF POU5F1;AUTOUBIQUITINATION
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