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Index > Protein center > XAF1(Gene name) > Human
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  • XAF1 (Gene name),
  • XIAP-associated factor 1 (Protein name ),  XAF1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    XAF1(BIRC4BP;XIAPAF1);
    Protein name:
    XIAP-associated factor 1;
    Alternative:
    BIRC4-binding protein;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with BIRC4; the interaction is not detected in (PubMed:16432762). Interacts with BIRC1, BIRC2, BIRC3, BIRC7 and BIRC8. Part of an complex consisting of BIRC4, XAF1 and BIRC5; the complex formation requires IFN-beta stimulation.
    Function:
    Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha-induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondra, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells.
    Subcellular Location:
    Isoform 5 Nucleus
    Protein Attributes:
    Sequence length:
    301
    Sequence:
    50:
    MEGDFSVCRN | CKRHVVSANF | TLHEAYCLRF | LVLCPECEEP | VPKETMEEHC | 
    100:
    KLEHQQVGCT | MCQQSMQKSS | LEFHKANECQ | ERPVECKFCK | LDMQLSKLEL | 
    150:
    HESYCGSRTE | LCQGCGQFIM | HRMLAQHRDV | CRSEQAQLGK | GERISAPERE | 
    200:
    IYCHYCNQMI | PENKYFHHMG | KCCPDSEFKK | HFPVGNPEIL | PSSLPSQAAE | 
    250:
    NQTSTMEKDV | RPKTRSINRF | PLHSESSSKK | APRSKNKTLD | PLLMSEPKPR | 
    300:
    TSSPRGDKAA | YDILRRCSQC | GILLPLPILN | QHQEKCRWLA | SSKGKQVRNF | 
    301:
    S
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    SMR:
    MIM:
    UniGene:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human XIAP-associated factor 1
    ELISA Kit for Human XIAP-associated factor 1
    ELISA Kit for Human XIAP-associated factor 1
    CLIA Kit for Human XIAP-associated factor 1
    CLIA Kit for Human XIAP-associated factor 1
    CLIA Kit for Human XIAP-associated factor 1
    Polyclonal Antibody for Human XIAP-associated factor 1
    Polyclonal Antibody for Human XIAP-associated factor 1
    Polyclonal Antibody for Human XIAP-associated factor 1
    Monoclonal Antibody for Human XIAP-associated factor 1
    Monoclonal Antibody for Human XIAP-associated factor 1
    Monoclonal Antibody for Human XIAP-associated factor 1
    Protein for Human XIAP-associated factor 1
    Protein for Human XIAP-associated factor 1
    Protein for Human XIAP-associated factor 1

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    Precision
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    Linearity
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    References
    1. 1.
      "Identification of XAF1 as an antagonist of XIAP anti-Caspase activity."
      Liston P. , Fong W.G. , Kelly N.L. , Toji S. , Miyazaki T. , Conte D. , Tamai K. , Craig C.G. , McBurney M.W. , Korneluk R.G.
      Nat. Cell Biol.3:128-133(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;INTERACTION WITH BIRC4;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
      tissue: Placenta.
    2. 2.
      "Frequent alteration of XAF1 in human colorectal cancers: implication for tumor cell resistance to apoptotic stresses."
      Chung S.K. , Lee M.G. , Ryu B.K. , Lee J.H. , Han J. , Byun D.S. , Chae K.S. , Lee K.Y. , Jang J.Y. , Kim H.J. , Chi S.G.
      Gastroenterology132:2459-2477(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4);TISSUE SPECIFICITY
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 6)
      tissue: Thymus.
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 7)
      tissue: Testis.
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-57
      tissue: Endometrium.
    7. 7.
      "Identification of X-linked inhibitor of apoptosis-associated factor-1 as an interferon-stimulated gene that augments TRAIL Apo2L-induced apoptosis."
      Leaman D.W. , Chawla-Sarkar M. , Vyas K. , Reheman M. , Tamai K. , Toji S. , Borden E.C.
      J. Biol. Chem.277:28504-28511(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION
    8. 8.
      "Identification of a novel splice variant of X-linked inhibitor of apoptosis-associated factor 1."
      Yin W. , Cheepala S. , Clifford J.L.
      Biochem. Biophys. Res. Commun.339:1148-1154(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING (ISOFORM 5);SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    9. 9.
      "Xaf1 can cooperate with TNFalpha in the induction of apoptosis, independently of interaction with XIAP."
      Xia Y. , Novak R. , Lewis J. , Duckett C.S. , Phillips A.C.
      Mol. Cell. Biochem.286:67-76(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN TNF-ALPHA-INDUCED APOPTOSIS;NEGATIVE INTERACTION WITH BIRC4
    10. 10.
      "Degradation of survivin by the X-linked inhibitor of apoptosis (XIAP)-XAF1 complex."
      Arora V. , Cheung H.H. , Plenchette S. , Micali O.C. , Liston P. , Korneluk R.G.
      J. Biol. Chem.282:26202-26209(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN BIRC5 DEGRADATION;INTERACTION WITH BIRC1; BIRC2; BIRC3; BIRC4; BIRC7 AND BIRC8
    11. 11.
      "XAF1 mediates tumor necrosis factor-alpha-induced apoptosis and X-linked inhibitor of apoptosis cleavage by acting through the mitochondrial pathway."
      Straszewski-Chavez S.L. , Visintin I.P. , Karassina N. , Los G. , Liston P. , Halaban R. , Fadiel A. , Mor G.
      J. Biol. Chem.282:13059-13072(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN TNF-ALPHA-INDUCED APOPTOSIS;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;INDUCTION
    12. 12.
      "ZNF313 is a novel cell cycle activator with an E3 ligase activity inhibiting cellular senescence by destabilizing p21(WAF1.)."
      Han J. , Kim Y.L. , Lee K.W. , Her N.G. , Ha T.K. , Yoon S. , Jeong S.I. , Lee J.H. , Kang M.J. , Lee M.G. , Ryu B.K. , Baik J.H. , Chi S.G.
      Cell Death Differ.20:1055-1067(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RNF114
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