Gene name:
Xaf1 (Birc4bp;Xiapaf1) ;
Protein name:
XIAP-associated factor 1 ;
Alternative:
BIRC4-binding protein ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with BIRC1, BIRC2, BIRC3, BIRC4, BIRC7 and BIRC8. Part of an complex consisting of BIRC4, XAF1 and BIRC5; the complex formation requires IFN-beta stimulation.
Function:
Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha-induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondra, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells.
Subcellular Location:
Cytoplasm
Nucleus
Mitochondrion
Protein Attributes:
50:
MEADFQVCRN | CKRNVASLHF | MLHEAHCLRF | IVLCPECEEP | IPESKMKEHM |
100:
EVVHQQTKES | QQHPAKCKFC | ELAVQLSNLD | VHESHCGSRT | EHCPHCNQPI |
150:
TLQVLSQHKA | MCLSAKGRPE | EGKRIVSSPG | RKTRCDLCKQ | MIPENTYASH |
200:
MKQCSAPNTV | TRIRDESIIV | IPSTLAFMDS | GNRRSTVSKD | VRPKTKNRNS |
250:
STKRETKKQN | GTVALPLKSG | LQQRADLPTG | DETAYDTLQN | CCQCRILLPL |
273:
PILNEHQEKC | QRLAHQKKLQ | WGW
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Bovine
Mouse
ELISA Kit for Mouse XIAP-associated factor 1
ELISA Kit for Mouse XIAP-associated factor 1
ELISA Kit for Mouse XIAP-associated factor 1
CLIA Kit for Mouse XIAP-associated factor 1
CLIA Kit for Mouse XIAP-associated factor 1
CLIA Kit for Mouse XIAP-associated factor 1
Polyclonal Antibody for Mouse XIAP-associated factor 1
Polyclonal Antibody for Mouse XIAP-associated factor 1
Polyclonal Antibody for Mouse XIAP-associated factor 1
Monoclonal Antibody for Mouse XIAP-associated factor 1
Monoclonal Antibody for Mouse XIAP-associated factor 1
Monoclonal Antibody for Mouse XIAP-associated factor 1
Protein for Mouse XIAP-associated factor 1
Protein for Mouse XIAP-associated factor 1
Protein for Mouse XIAP-associated factor 1
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
C57BL/6J .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-205 (ISOFORM 1)
strain :
C57BL/6J .
tissue :
Adipose tissue .