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Index > Protein center > Xirp2(Gene name) > Mouse
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  • Xirp2 (Gene name),
  • Xin actin-binding repeat-containing protein 2 (Protein name ),  XIRP2_MOUSE from NCBI database.
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  • Gene name:
    Xirp2(Cmya3;Xin2);
    Protein name:
    Xin actin-binding repeat-containing protein 2;
    Alternative:
    Cardiomyopathy-associated protein 3;Beta-xin;Myomaxin;Myogenic MEF2-activated Xin-related protein;mXinbeta;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with ACTN2. Interacts with F-actin.
    Function:
    Protects actin filaments from depolymerization.
    Subcellular Location:
    Cell junction Colocalizes with actin stress fibers.
    Protein Attributes:
    Sequence length:
    3784
    Sequence:
    50:
    MARYQAAVSR | GDTRSFSANV | MEESDVCTVP | GGLAKMKRQF | EKDKMTSTCN | 
    100:
    AFSEYQYRHE | SRAEQEAIHS | SQEIIRRNEQ | EVSKGHGTDV | FKAEMMSHLE | 
    150:
    KHTEETKQAS | QFHQYVQETV | IDSPEEEELP | KVSTKILKEQ | FEKSAQENFL | 
    200:
    RSDKETSPPA | KCMKIENDIE | ETLKPSSAVG | TSSSYTSTRQ | RKETSTSSYS | 
    250:
    NHSLTSTTLA | QDNGTPSGKM | EEFPPPPPDV | CQTPMDVTAF | SQSPEFPSPP | 
    300:
    RRLPMPKDLY | SKQRNLYELN | RLYRHIHPEL | RKNLEKDYIS | EVSEIVSSQI | 
    350:
    NSGNALSADV | QKARYVFENT | NDSSQKDLNS | ERENLEWDEI | LKGEVQSIRW | 
    400:
    IFENQPLDSI | NHGSTDEGYT | SKGIADQELI | AGSDVKYTTW | MFETQPIDAL | 
    450:
    GIPSAGTEGN | TEKIPELARG | DVYTARWMFE | TRPLDSMNKM | HECQEETAST | 
    500:
    LTKDITGGDV | KTVRYMFETQ | QLDQLGQLHS | VDELNLLQLR | SELKEIKGNV | 
    550:
    KRSIKCFETQ | PLYVIRDGSG | QMLEIKTVQR | EDIEKGDVRT | ARWMFETQPL | 
    600:
    DTINKDITEI | KVVRGISMEE | NVKGGVSRAK | WLFETQPLEK | IKEESGEAVL | 
    650:
    KTEAVIGTDV | SKKCWMFETQ | PLDILKDSPD | TDSVSPEERI | GGDVKTTKHL | 
    700:
    FETLPIEALK | DSPDIGKLQK | ITASEEEKGD | VKHQKWVFET | QRLEDIREDK | 
    750:
    KEYTRTVRLE | AVDRGHVKNY | THIFESNNLI | KVDASHQIEV | EGVTRGTVEL | 
    800:
    NKSLFETTPL | YAIQDHLGKY | HQVKTVQQEE | IVRGDVRSCR | WLFETRPIDQ | 
    850:
    FDESLHKFQI | IRGISAQEIQ | AGNVKSARWL | FETQPLDSIK | YFSNVEETDS | 
    900:
    KTEQSTDIVK | GDVKTCKWLF | ETQPMESLYE | KASLMTNSED | IHKGDVRTCM | 
    950:
    WLFETQPLDA | IKDDSEATVK | LQTVKQEEIQ | GGDVQTACFL | FETENLDNIQ | 
    1000:
    GDEGKENKPL | EMDIQSGDVS | GMKFKFENQS | LDSINCSSEN | VLSKIKTLKA | 
    1050:
    EDIQKGNVLK | CRWLFENQPI | DMIKESQECD | GLVKTVTDVQ | GGDVRKGCFI | 
    1100:
    FETFSLDEIK | DESDGISMRE | TNLGEIIKGD | VKSYKMLFET | QPLYAIQDHE | 
    1150:
    GFYHEVTTVK | KEETIHGDVR | GTRWLFETKP | LDSIHESEDV | YVIKSVTQED | 
    1200:
    IQKGDVSSVR | YRFETQPLDM | ISDKSHNIVP | TVDYIQGGNV | QMNKQLFESE | 
    1250:
    GGNKKNYVRT | VSVNEIQKGN | VKTSTWLFET | HRIDELGEES | RYENIKTVTQ | 
    1300:
    EDVQKGDVKQ | AVWLFENQTL | DSINELDEND | TKMTKEEIPP | SDVKTTTWLF | 
    1350:
    ETTPIHEFNK | TRVEKEEIIG | KSIKETLEDL | YSQRVVEAPG | IIIEADEVGD | 
    1400:
    VRMAKYKLMN | QTTPEIQKEE | VIRADLGNIM | MNLLSQRDCT | KKEIFVSEEE | 
    1450:
    KGNVNFTKTQ | LLNRSMEFHA | EKEEIVRGDV | KQAIQKLFSE | ERRAKKGILI | 
    1500:
    QEDEKGDINM | TIYCLLHENA | GDKTEREDIL | GGDVRRTIHN | LLSSASNGKI | 
    1550:
    SERTKIDASE | RGNVQFFTTC | IETGALDYLK | QLQTGSNEST | LTASKQEGEE | 
    1600:
    EIIGGDVEGT | KFLLKKRQSS | FERTVSETDI | IPGDVRHTVK | VFMTEPQSSS | 
    1650:
    YKTVKDEIIK | GDLKSTLNSL | NQAMNQKTVA | KAEEIVKDDR | LAILKSLKES | 
    1700:
    GDRQKEPKQS | GGMSRDIGQA | IECLERATNT | RTEILKKELI | LDDLKTSLRS | 
    1750:
    LKEEQCGFKE | VDKQGIVKDV | LPGMLGFSER | PKIGIHPAAV | QRDKKSLLQP | 
    1800:
    VPGPFEPAIK | QQAGPGTLDE | TTQKPCLRSL | IEERTEANLP | KAPKGTVKIV | 
    1850:
    IDREQNNDAL | EKSLRKMSNS | EHRAMKNVLD | MSDRMGIWTE | SKEYLCSDDH | 
    1900:
    MSKHLSATMS | IKESLKSKES | ENMREAKDDV | ISSTQSVDKT | FRKQQTQTCE | 
    1950:
    LGNDQKSRFQ | DSYGKNQKNI | QNIEITRDFQ | KQALLSQEKQ | YSNKEMKKNE | 
    2000:
    ASLQPLPVGK | EVHSVPGVTV | SGKNHKRIQA | TDKRQKTDVC | LESQDFLMKT | 
    2050:
    NTSKELKMAM | ERSFNPINLH | PECGIKENED | SLPPPSPPPL | PPSNASSEIE | 
    2100:
    FPLPPPPPLM | LLPGKNESPP | SSPTEKTRTE | FESLSTLPLP | PPPVDEKAEQ | 
    2150:
    ECLSTTLPPP | PPPTPCQPGH | LLPSSVLGHH | REAFLQQFSQ | KEALGVHLPH | 
    2200:
    SQAKILTGKS | PPPTLPKPKL | PKRIKDKMNQ | YSSSGELERS | LSDVEIKATL | 
    2250:
    SKDQKRSMVT | MSSEHRETKQ | DVFGKGLVGR | KQLPVDSANS | LSQTVPEIPA | 
    2300:
    PKEKQTAPLV | KSHSFPSGSE | QQSPKPYMRK | FKTPLMIAEE | KYRQQREELE | 
    2350:
    KQRQESSSHN | VIKTETQHQS | LSEKEEEIEL | QKATEAISTP | RKESDFPRAR | 
    2400:
    PNLDSESRAV | IAGECSESQL | ATASTLTVAT | ERLQHVLAAS | EDELTLRQEG | 
    2450:
    IQNSSDASQS | KLACETSQSH | KECKAQQTFE | QHVKRLPFPQ | TKPSSPSFKV | 
    2500:
    KTIKLSTLDH | TGTETDLSSK | HHTKQSEVDI | QTSTEQTDKE | IKKTQASIQC | 
    2550:
    DDKPSVPEKY | FQLPKTEKRV | TIQMPKEYAE | KSHKSKLQTV | PKKQGIFGEF | 
    2600:
    DRGNVLGREG | KNQDSSVSCS | KEDRLIDERK | QEHLQNQRVP | RSVQQKVINE | 
    2650:
    RLDSQMQNFQ | QTEIQTSRST | IECEEFSQSY | NATQEKTCLK | DKGKQQGQVT | 
    2700:
    SNTEESKQEL | RQNQSAFSSV | KDSQHDDGKC | TINILEFLRK | REELQQILSR | 
    2750:
    VKQFEAESSK | SGLKTFQILL | NIVPVWLISE | EKREYGVRVA | MENNFEKVKE | 
    2800:
    EITHIKTQAE | EMLLQCEHVI | QTAMMASQTG | KQRDKPTNLN | EMPLNVSNVN | 
    2850:
    LSSSKCTEQK | ESKTVEEKLT | HRQVTTHPEA | ATRNPVKPYQ | EAKGEDGKMA | 
    2900:
    PPSLKTRPPS | PTFITIESTA | RRAETSTKSE | LSQSPKNNRC | IEPPPRRPVE | 
    2950:
    HASGLPRSRT | PPSPPRSRSE | QLVRLKDTTA | RLAKGTIPCS | PGTPVPIVEK | 
    3000:
    RSEVVMSPAT | LRRQIKIESR | GGDSPPTITI | PVSVNHVVSG | SFRESVDAQE | 
    3050:
    AVKKTEKTET | YVHKDKMNSV | NRAMPETESY | DAVEIIRKVE | GPHLSEHTER | 
    3100:
    FEATNQTVQR | AERFLNGHEN | EINRWFREFE | NDPVFRAKTE | RGAYANGEIN | 
    3150:
    HNMKQESHTF | CKEEFGLASS | ETANFTGFSY | RHPKVPAMQP | RVHSEARSLN | 
    3200:
    EHFSSVDAFD | SQIVGSKVAT | SSSRSTEAGR | SGFDFKHAPP | TYEDVISGHI | 
    3250:
    LDVADSPTNL | RRNFQKTWQE | SERVFQRVGY | ETSDAHATEM | SRAFQEESAF | 
    3300:
    LSDKEICIIC | QKTVYPMECL | IADKQNFHKS | CFRCHHCSSK | LSLGNYASLH | 
    3350:
    GRIYCKPHFK | QLFKSKGNYD | EGFGHKQHKD | RWNCKNQSSL | VDFIPSGEPD | 
    3400:
    AHENPTADTL | LLGDLTTHPD | ACNSKRQDND | LRKWGDRGKL | KIVWPPCQEM | 
    3450:
    PKKNSPPEEE | FKVNKAKWPP | EVTIPVPSDF | KRESLTEHVK | TLESQGQEQD | 
    3500:
    SVPDLQPCKH | VCQKEDITGI | KEIKGYEERK | DEKEAKDTLK | DAEGLRSKRK | 
    3550:
    SGMEFNDHNA | HAQSDGKEKN | ALVNEADSAD | VLQVANTDDE | GGPENHRENF | 
    3600:
    NNNNNNSVAV | SSLNNGRQKI | SISERPRLLQ | AVSEANYYTS | EYQIKNFNNA | 
    3650:
    SKISELLGIF | ESQKLSSKKV | LALALERTAD | RGTAGSPLQL | VLEPGLQQGF | 
    3700:
    SVKGENLAAS | PDVSPLHIKG | NHENNKNVHL | FFSNTVKITS | FSKKHNILGC | 
    3750:
    DLMDSVDQLK | NMSCLYLREL | GKNVKCWHGE | TAGAARHGGK | MCFDAQSQGS | 
    3784:
    AAKPVFPSMQ | CQAQHLTVEE | QIKRDRCYSD | SEAD
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    String:
    UniGene:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Xin actin-binding repeat-containing protein 2
    ELISA Kit for Mouse Xin actin-binding repeat-containing protein 2
    ELISA Kit for Mouse Xin actin-binding repeat-containing protein 2
    CLIA Kit for Mouse Xin actin-binding repeat-containing protein 2
    CLIA Kit for Mouse Xin actin-binding repeat-containing protein 2
    CLIA Kit for Mouse Xin actin-binding repeat-containing protein 2
    Polyclonal Antibody for Mouse Xin actin-binding repeat-containing protein 2
    Polyclonal Antibody for Mouse Xin actin-binding repeat-containing protein 2
    Polyclonal Antibody for Mouse Xin actin-binding repeat-containing protein 2
    Monoclonal Antibody for Mouse Xin actin-binding repeat-containing protein 2
    Monoclonal Antibody for Mouse Xin actin-binding repeat-containing protein 2
    Monoclonal Antibody for Mouse Xin actin-binding repeat-containing protein 2
    Protein for Mouse Xin actin-binding repeat-containing protein 2
    Protein for Mouse Xin actin-binding repeat-containing protein 2
    Protein for Mouse Xin actin-binding repeat-containing protein 2

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    References
    1. 1.
      "Myomaxin is a novel transcriptional target of MEF2A that encodes a Xin-related alpha-actinin-interacting protein."
      Huang H.-T. , Brand O.M. , Mathew M. , Ignatiou C. , Ewen E.P. , McCalmon S.A. , Naya F.J.
      J. Biol. Chem.281:39370-39379(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);INDUCTION;TISSUE SPECIFICITY;INTERACTION WITH ACTN2
      tissue: Skeletal muscle.
    2. 2.
      "Thm1 is a novel negative regulator of mouse Sonic hedgehog signaling."
      Tran P.V. , Herron B.J. , Scherz P.J. , Qiu H. , Turbe-Doan A. , Parker K. , Beier D.R.
      Submitted (2005-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      strain: A/J.
    3. 3.
      Xie L. , Wang K.
      Submitted (2006-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
      tissue: Heart.
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    5. 5.
      "Loss of mXinalpha, an intercalated disk protein, results in cardiac hypertrophy and cardiomyopathy with conduction defects."
      Gustafson-Wagner E.A. , Sinn H.W. , Chen Y.-L. , Wang D.-Z. , Reiter R.S. , Lin J.L.-C. , Yang B. , Williamson R.A. , Chen J. , Lin C.-I. , Lin J.J.-C.
      Am. J. Physiol.293:H2680-H2692(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-1427 (ISOFORM 1);TISSUE SPECIFICITY;SUBCELLULAR LOCATION
      strain: C57BL/6.
    6. 6.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-493
      strain: C57BL/6J.
      tissue: Aorta.
    7. 7.
      "A novel gene (Cmya3) induced in the heart by angiotensin II-dependent but not salt-dependent hypertension in mice."
      Duka A. , Schwartz F. , Duka I. , Johns C. , Melista E. , Gavras I. , Gavras H.
      Am. J. Hypertens.19:275-281(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
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