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Index > Protein center > XPA(Gene name) > Human
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  • XPA (Gene name),
  • DNA repair protein complementing XP-A cells (Protein name ),  XPA_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    XPA(XPAC);
    Protein name:
    DNA repair protein complementing XP-A cells;
    Alternative:
    Xeroderma pigmentosum group A-complementing protein;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with GPN1 and RPA1. Interacts (via N-terminus) with CEP164 upon UV irradiation. Interacts with HERC2.
    Function:
    Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    273
    Sequence:
    50:
    MAAADGALPE | AAALEQPAEL | PASVRASIER | KRQRALMLRQ | ARLAARPYSA | 
    100:
    TAAAATGGMA | NVKAAPKIID | TGGGFILEEE | EEEEQKIGKV | VHQPGPVMEF | 
    150:
    DYVICEECGK | EFMDSYLMNH | FDLPTCDNCR | DADDKHKLIT | KTEAKQEYLL | 
    200:
    KDCDLEKREP | PLKFIVKKNP | HHSQWGDMKL | YLKLQIVKRS | LEVWGSQEAL | 
    250:
    EEAKEVRQEN | REKMKQKKFD | KKVKELRRAV | RSSVWKRETI | VHQHEYGPEE | 
    273:
    NLEDDMYRKT | CTMCGHELTY | EKM
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    MIM:
    Pfam:
    SMR:
    KEGG:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human DNA repair protein complementing XP-A cells
    ELISA Kit for Human DNA repair protein complementing XP-A cells
    ELISA Kit for Human DNA repair protein complementing XP-A cells
    CLIA Kit for Human DNA repair protein complementing XP-A cells
    CLIA Kit for Human DNA repair protein complementing XP-A cells
    CLIA Kit for Human DNA repair protein complementing XP-A cells
    Polyclonal Antibody for Human DNA repair protein complementing XP-A cells
    Polyclonal Antibody for Human DNA repair protein complementing XP-A cells
    Polyclonal Antibody for Human DNA repair protein complementing XP-A cells
    Monoclonal Antibody for Human DNA repair protein complementing XP-A cells
    Monoclonal Antibody for Human DNA repair protein complementing XP-A cells
    Monoclonal Antibody for Human DNA repair protein complementing XP-A cells
    Protein for Human DNA repair protein complementing XP-A cells
    Protein for Human DNA repair protein complementing XP-A cells
    Protein for Human DNA repair protein complementing XP-A cells

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Analysis of a human DNA excision repair gene involved in group A Xeroderma pigmentosum and containing a zinc-finger domain."
      Tanaka K. , Miura N. , Satokata I. , Miyamoto I. , Yoshida M.C. , Satoh Y. , Kondo S. , Yasui A. , Okayama H. , Okada Y.
      Nature348:73-76(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Fibroblast.
    2. 2.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    3. 3.
      NIEHS SNPs program
      Submitted (2002-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT GLU-78 DEL
    4. 4.
      "DNA sequence and analysis of human chromosome 9."
      Humphray S.J. , Oliver K. , Hunt A.R. , Plumb R.W. , Loveland J.E. , Howe K.L. , Andrews T.D. , Searle S. , Hunt S.E. , Scott C.E. , Jones M.C. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Ashwell R.I.S. , Babbage A.K. , Babbage S. , Bagguley C.L. , more...
      Nature429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: B-cell.
    7. 7.
      "Genomic characterization of the human DNA excision repair-controlling gene XPAC."
      Satokata I. , Iwai K. , Matsuda T. , Okada Y. , Tanaka K.
      Gene136:345-348(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-57
      tissue: Spermatocyte.
    8. 8.
      "RPA involvement in the damage-recognition and incision steps of nucleotide excision repair."
      He Z. , Henricksen L.A. , Wold M.S. , Ingles C.J.
      Nature374:566-569(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RPA1 AND RPA2
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 59-273;TISSUE SPECIFICITY
      tissue: Placenta.
    10. 10.
      "Identification and characterization of xpac protein, the gene product of the human XPAC (Xeroderma pigmentosum group A complementing) gene."
      Miura N. , Miyamoto I. , Asahina H. , Satokata I. , Tanaka K. , Okada Y.
      J. Biol. Chem.266:19786-19789(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    11. 11.
      "Mutational analysis of the structure and function of the Xeroderma pigmentosum group A complementing protein. Identification of essential domains for nuclear localization and DNA excision repair."
      Miyamoto I. , Miura N. , Niwa H. , Miyazaki J. , Tanaka K.
      J. Biol. Chem.267:12182-12187(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS
    12. 12.
      "Molecular analysis of Xeroderma pigmentosum group A gene."
      Tanaka K.
      Jpn. J. Hum. Genet.38:1-14(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON VARIANTS XP-A
    13. 13.
      "A summary of mutations in the UV-sensitive disorders: xeroderma pigmentosum, Cockayne syndrome, and trichothiodystrophy."
      Cleaver J.E. , Thompson L.H. , Richardson A.S. , States J.C.
      Hum. Mutat.14:9-22(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON VARIANTS XP-A
    14. 14.
      "Phosphorylation of nucleotide excision repair factor xeroderma pigmentosum group A by ataxia telangiectasia mutated and Rad3-related-dependent checkpoint pathway promotes cell survival in response to UV irradiation."
      Wu X. , Shell S.M. , Yang Z. , Zou Y.
      Cancer Res.66:2997-3005(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-196
    15. 15.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
    16. 16.
      "UV-dependent interaction between Cep164 and XPA mediates localization of Cep164 at sites of DNA damage and UV sensitivity."
      Pan Y.R. , Lee E.Y.
      Cell Cycle8:655-664(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CEP164;SUBCELLULAR LOCATION
    17. 17.
      "Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase."
      Kang T.H. , Lindsey-Boltz L.A. , Reardon J.T. , Sancar A.
      Proc. Natl. Acad. Sci. U.S.A.107:4890-4895(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION;SUBCELLULAR LOCATION;INTERACTION WITH HERC2
      tissue: Embryonic kidney.
      tissue: Lung adenocarcinoma.
    18. 18.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    19. 19.
      "Solution structure of the DNA- and RPA-binding domain of the human repair factor XPA."
      Ikegami T. , Kuraoka I. , Saijo M. , Kodo N. , Kyogoku Y. , Morikawa K. , Tanaka K. , Shirakawa M.
      Nat. Struct. Biol.5:701-706(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 98-219;DNA-BINDING;INTERACTION WITH RPA1
    20. 20.
      "Interactions of human nucleotide excision repair protein XPA with DNA and RPA70 Delta C327: chemical shift mapping and 15N NMR relaxation studies."
      Buchko G.W. , Daughdrill G.W. , de Lorimier R. , Sudha Rao B.K. , Isern N.G. , Lingbeck J.M. , Taylor J.-S. , Wold M.S. , Gochin M. , Spicer L.D. , Lowry D.F. , Kennedy M.A.
      Biochemistry38:15116-15128(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 98-208;DNA-BINDING;INTERACTION WITH RPA1
    21. 21.
      "Molecular basis of group A Xeroderma pigmentosum: a missense mutation and two deletions located in a zinc finger consensus sequence of the XPAC gene."
      Satokata I. , Tanaka K. , Okada Y.
      Hum. Genet.88:603-607(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT XP-A PHE-108
    22. 22.
      "Identification of splicing mutations of the last nucleotides of exons, a nonsense mutation, and a missense mutation of the XPAC gene as causes of group A Xeroderma pigmentosum."
      Satokata I. , Tanaka K. , Yuba S. , Okada Y.
      Mutat. Res.273:203-212(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT XP-A ARG-244
    23. 23.
      "Distribution of mutations in the human Xeroderma pigmentosum group A gene and their relationships to the functional regions of the DNA damage recognition protein."
      States J.C. , McDuffie E.R. , Myrand S.P. , McDowell M. , Cleaver J.E.
      Hum. Mutat.12:103-113(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT XP-A PHE-108
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