Protein name:
DNA repair endonuclease XPF ;
Alternative:
DNA excision repair protein ERCC-4 ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Heterodimer composed of ERCC1 and XPF/ERCC4. Interacts with EME1. Interacts with SLX4/BTBD12; this interaction is direct and links the ERCC1-XPF/ERCC1 complex to SLX4, which may coordinate the action of the structure-specific endonuclease during DNA repair.
Function:
Structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair. Involved in homologous recombination that assists in removing interstrand cross-link.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MEPGLSGERR | SMAPLLEYER | QQVLELLDSD | GLVVCARGLG | TDRLLYHFLR |
100:
LHCHPACLVL | VLNTQPAEEE | YFINQLKIEG | VEHLPRRVTN | EIASNSRYEV |
150:
YTQGGIIFAT | SRILVVDFLT | GRIPSDLITG | ILVYRAHRII | ESCQEAFILR |
200:
LFRQKNKRGF | IKAFTDNAVA | FDTGFCHVER | VMRNLFVRKL | YLWPRFHVAV |
250:
NSFLEQHKPE | VVEIHVSMTP | AMLAIQTAIL | DILNACLKEL | KCHNPSLEVE |
300:
DLSLENALGK | PFDKTIRHYL | DPLWHQLGAK | TKSLVQDLKI | LRTLLQYLSQ |
350:
YDCVTFLNLL | ESLRATEKVF | GQNSGWLFLD | ASTSMFVNAR | ARVYRVPDVK |
400:
LNKKAKTSEK | TSSPEVQETK | KELVLESNPK | WEALTDVLKE | IEAENKESEA |
450:
LGGPGRVLIC | ASDDRTCCQL | RDYLSAGAET | FLLRLYRKTF | EKDGKAEEVW |
500:
VNVRKGDGPK | RTTKSDKRPK | AAPNKERASA | KRGAPLKRKK | QELTLTQVLG |
550:
SAEEPPEDKA | LEEDLCRQTS | SSPEGCGVEI | KRESFDLNVS | SDAAYGILKE |
600:
PLTIIHPLLG | CSDPYALTRV | LHEVEPRYVV | LYDAELTFVR | QLEIYRASRP |
650:
GKPLRVYFLI | YGGSTEEQRY | LTALRKEKEA | FEKLIREKAS | MVVPEEREGR |
700:
DETNLDLARG | SAALDAPTDT | RKAGGQEQNG | TQSSIVVDMR | EFRSELPSLI |
750:
HRRGIDIEPV | TLEVGDYILT | PELCVERKSV | SDLIGSLHSG | RLYSQCLAMS |
800:
RYYRRPVLLI | EFDPSKPFSL | APRGAFFQEM | SSSDVSSKLT | LLTLHFPRLR |
850:
LLWCPSPHAT | AELFEELKQN | KPQPDAATAM | AITADSETLP | ESDRYNPGPQ |
900:
DFVLKMPGVN | AKNCRSLMNQ | VKNIAELATL | SLERLTTILG | HSGNAKQLHD |
917:
FLHTAYADLV | SKGRVRK
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
ELISA Kit for Mouse DNA repair endonuclease XPF
ELISA Kit for Mouse DNA repair endonuclease XPF
CLIA Kit for Mouse DNA repair endonuclease XPF
CLIA Kit for Mouse DNA repair endonuclease XPF
Polyclonal Antibody for Mouse DNA repair endonuclease XPF
Polyclonal Antibody for Mouse DNA repair endonuclease XPF
Monoclonal Antibody for Mouse DNA repair endonuclease XPF
Monoclonal Antibody for Mouse DNA repair endonuclease XPF
Protein for Mouse DNA repair endonuclease XPF
Protein for Mouse DNA repair endonuclease XPF
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
2.
"Sequence analysis of a mouse BAC containing the DNA repair gene Ercc-4 (XPF)."
Lamerdin J.E.
,
McCready P.M.
,
Skowronski E.
,
Adamson A.W.
,
Burkhart-Schultz K.
,
Gordon L.
,
Kyle A.
,
Ramirez M.
,
Stilwagen S.
,
Phan H.
,
Velasco N.
,
Garnes J.
,
Danganan L.
,
Poundstone P.
,
Christensen M.
,
Georgescu A.
,
Avila J.
,
Liu S.
,
Attix C.
,
Andreise T.
,
Trankheim M.
,
Amico-Keller G.
,
Coefield J.
,
Duarte S.
,
Lucas S.
,
Bruce R.
,
Thomas P.
,
Quan G.
,
Kronmiller B.
,
Arellano A.
,
Montgomery M.
,
Ow D.
,
Nolan M.
,
Trong S.
,
Kobayashi A.
,
Olsen A.O.
,
Carrano A.V.
more...
Submitted (1998-02) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5-917
tissue :
Salivary gland .