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Index > Protein center > XPNPEP1(Gene name) > Human
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  • XPNPEP1 (Gene name),
  • Xaa-Pro aminopeptidase 1 (Protein name ),  XPP1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    XPNPEP1(XPNPEPL;XPNPEPL1);
    Protein name:
    Xaa-Pro aminopeptidase 1;
    Alternative:
    Cytosolic aminopeptidase P;Aminoacylproline aminopeptidase;X-Pro aminopeptidase 1;Soluble aminopeptidase P(sAmp);X-prolyl aminopeptidase 1, soluble;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer.
    Function:
    Contributes to the degradation of bradykinin. Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    623
    Sequence:
    50:
    MPPKVTSELL | RQLRQAMRNS | EYVTEPIQAY | IIPSGDAHQS | EYIAPCDCRR | 
    100:
    AFVSGFDGSA | GTAIITEEHA | AMWTDGRYFL | QAAKQMDSNW | TLMKMGLKDT | 
    150:
    PTQEDWLVSV | LPEGSRVGVD | PLIIPTDYWK | KMAKVLRSAG | HHLIPVKENL | 
    200:
    VDKIWTDRPE | RPCKPLLTLG | LDYTGISWKD | KVADLRLKMA | ERNVMWFVVT | 
    250:
    ALDEIAWLFN | LRGSDVEHNP | VFFSYAIIGL | ETIMLFIDGD | RIDAPSVKEH | 
    300:
    LLLDLGLEAE | YRIQVHPYKS | ILSELKALCA | DLSPREKVWV | SDKASYAVSE | 
    350:
    TIPKDHRCCM | PYTPICIAKA | VKNSAESEGM | RRAHIKDAVA | LCELFNWLEK | 
    400:
    EVPKGGVTEI | SAADKAEEFR | RQQADFVDLS | FPTISSTGPN | GAIIHYAPVP | 
    450:
    ETNRTLSLDE | VYLIDSGAQY | KDGTTDVTRT | MHFGTPTAYE | KECFTYVLKG | 
    500:
    HIAVSAAVFP | TGTKGHLLDS | FARSALWDSG | LDYLHGTGHG | VGSFLNVHEG | 
    550:
    PCGISYKTFS | DEPLEAGMIV | TDEPGYYEDG | AFGIRIENVV | LVVPVKTKYN | 
    600:
    FNNRGSLTFE | PLTLVPIQTK | MIDVDSLTDK | ECDWLNNYHL | TCRDVIGKEL | 
    623:
    QKQGRQEALE | WLIRETQPIS | KQH
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    String:
    Pfam:
    UniGene:
    KEGG:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Xaa-Pro aminopeptidase 1
    ELISA Kit for Human Xaa-Pro aminopeptidase 1
    ELISA Kit for Human Xaa-Pro aminopeptidase 1
    ELISA Kit for Human Xaa-Pro aminopeptidase 1
    CLIA Kit for Human Xaa-Pro aminopeptidase 1
    CLIA Kit for Human Xaa-Pro aminopeptidase 1
    CLIA Kit for Human Xaa-Pro aminopeptidase 1
    CLIA Kit for Human Xaa-Pro aminopeptidase 1
    Polyclonal Antibody for Human Xaa-Pro aminopeptidase 1
    Polyclonal Antibody for Human Xaa-Pro aminopeptidase 1
    Polyclonal Antibody for Human Xaa-Pro aminopeptidase 1
    Polyclonal Antibody for Human Xaa-Pro aminopeptidase 1
    Monoclonal Antibody for Human Xaa-Pro aminopeptidase 1
    Monoclonal Antibody for Human Xaa-Pro aminopeptidase 1
    Monoclonal Antibody for Human Xaa-Pro aminopeptidase 1
    Monoclonal Antibody for Human Xaa-Pro aminopeptidase 1
    Protein for Human Xaa-Pro aminopeptidase 1
    Protein for Human Xaa-Pro aminopeptidase 1
    Protein for Human Xaa-Pro aminopeptidase 1
    Protein for Human Xaa-Pro aminopeptidase 1

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Isolation and sequence analysis of a human cDNA clone (XPNPEPL) homologous to X-prolyl aminopeptidase (aminopeptidase P)."
      Vanhoof G. , Goossens F. , Juliano M.A. , Juliano L. , Hendriks D. , Schatteman K. , Lin A.H. , Scharpe S.
      Cytogenet. Cell Genet.78:275-280(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
      tissue: Lymphocyte.
    2. 2.
      "Cloning, chromosomal sublocalization of the human soluble aminopeptidase P gene (XPNPEP1) to 10q25.3 and conservation of the putative proton shuttle and metal ligand binding sites with XPNPEP2."
      Sprinkle T.J. , Caldwell C. , Ryan J.W.
      Arch. Biochem. Biophys.378:51-56(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    3. 3.
      "Cloning, expression, and characterization of human cytosolic aminopeptidase P: a single manganese(II)-dependent enzyme."
      Cottrell G.S. , Hooper N.M. , Turner A.J.
      Biochemistry39:15121-15128(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);CATALYTIC ACTIVITY;COFACTOR;ENZYME REGULATION;BIOPHYSICOCHEMICAL PROPERTIES;SUBUNIT
      tissue: Pancreatic adenocarcinoma.
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
    5. 5.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    6. 6.
      Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
      Submitted (2005-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Adipose tissue.
    8. 8.
      "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
      Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    10. 10.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Colon.
      tissue: Ovary.
      tissue: Placenta.
    11. 11.
      "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
      Gevaert K. , Goethals M. , Martens L. , Van Damme J. , Staes A. , Thomas G.R. , Vandekerckhove J.
      Nat. Biotechnol.21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-11
      tissue: Platelet.
    12. 12.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-304;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    14. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    15. 15.
      "Structure of human cytosolic X-prolyl aminopeptidase: a double Mn(II)-dependent dimeric enzyme with a novel three-domain subunit."
      Li X. , Lou Z. , Li X. , Zhou W. , Ma M. , Cao Y. , Geng Y. , Bartlam M. , Zhang X.C. , Rao Z.
      J. Biol. Chem.283:22858-22866(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) IN COMPLEX WITH MANGANESE IONS;COFACTOR;CATALYTIC ACTIVITY;BIOPHYSICOCHEMICAL PROPERTIES;MUTAGENESIS OF GLU-41 AND TRP-477;SUBUNIT
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