XYLT1 ELISA Kit for Human(Homo sapiens) | EIAab.comXYLT1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > XYLT1(Gene name) > Human

XYLT1 (Gene name),

Xylosyltransferase 1 (Protein name ), XYLT1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

XYLT1(XT1);

Protein name:

Xylosyltransferase 1;

Alternative:

Xylosyltransferase I(XT-I;XylT-I);Peptide O-xylosyltransferase 1;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Monomer.

Function:

Catalyzes the first step in biosynthesis of glycosaminoglycan. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes.

Subcellular Location:

Endoplasmic reticulum membrane Single-pass type II membrane protein Golgi apparatus membrane Single-pass type II membrane protein Secreted Some fraction is also found in the extracellular space together with chondroitin sulfate proteoglycans, suggesting that it can be secreted.

Protein Attributes:

Sequence length:

959

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

950:

959:

AVKPDGRLR

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:64131

UniGene:

Hs.22907

STRING:

9606.ENSP00000261381

String:

Q86Y38

SMR:

Q86Y38

MIM:

608124

Pfam:

PF02485

Uniprot:

Q86Y38

FOR

ELISA Kit for Human Xylosyltransferase 1

Cat.:

E11585h

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Manual:

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96T

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ELISA Kit for Human Xylosyltransferase 1

Cat.:

E11585d

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96T

ELISA Kit for Human Xylosyltransferase 1

Cat.:

E11585m

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96T

ELISA Kit for Human Xylosyltransferase 1

Cat.:

E11585r

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96T

CLIA Kit for Human Xylosyltransferase 1

Cat.:

U11585d

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96T

CLIA Kit for Human Xylosyltransferase 1

Cat.:

U11585h

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96T

CLIA Kit for Human Xylosyltransferase 1

Cat.:

U11585r

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Packing:

96T

CLIA Kit for Human Xylosyltransferase 1

Cat.:

U11585m

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Packing:

96T

Polyclonal Antibody for Human Xylosyltransferase 1

Cat.:

P11585Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Xylosyltransferase 1

Cat.:

P11585Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Xylosyltransferase 1

Cat.:

P11585Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Xylosyltransferase 1

Monoclonal Antibody for Human Xylosyltransferase 1

Protein for Human Xylosyltransferase 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Human xylosyltransferase I: functional and biochemical characterization of cysteine residues required for enzymic activity."
Mueller S. , Schoettler M. , Schoen S. , Prante C. , Brinkmann T. , Kuhn J. , Goetting C. , Kleesiek K.
Biochem. J.386:227-236(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];DISULFIDE BONDS;COFACTOR;BIOPHYSICOCHEMICAL PROPERTIES;SUBUNIT;MUTAGENESIS OF CYS-257; CYS-276; CYS-285; CYS-301; CYS-471; CYS-542; CYS-561; CYS-563; CYS-572; CYS-574; CYS-675; CYS-920; CYS-927 AND CYS-933
2.

"Molecular cloning and expression of human UDP-D-xylose:proteoglycan core protein beta-D-xylosyltransferase and its first isoform XT-II."
Goetting C. , Kuhn J. , Zahn R. , Brinkmann T. , Kleesiek K.
J. Mol. Biol.304:517-528(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 133-959;TISSUE SPECIFICITY
3.

"First isolation of human UDP-D-xylose: proteoglycan core protein beta-D-xylosyltransferase secreted from cultured JAR choriocarcinoma cells."
Kuhn J. , Goetting C. , Schnoelzer M. , Kempf T. , Brinkmann T. , Kleesiek K.
J. Biol. Chem.276:4940-4947(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 159-171; 185-202; 289-296; 444-449; 593-598; 727-748 AND 948-959;GLYCOSYLATION
4.

"Serum xylosyltransferase: a new biochemical marker of the sclerotic process in systemic sclerosis."
Goetting C. , Sollberg S. , Kuhn J. , Weilke C. , Huerkamp C. , Brinkmann T. , Krieg T. , Kleesiek K.
J. Invest. Dermatol.112:919-924(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
5.

"Xylosyltransferase activity in seminal plasma of infertile men."
Goetting C. , Kuhn J. , Brinkmann T. , Kleesiek K.
Clin. Chim. Acta317:199-202(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REDUCED ACTIVITY IN SEMINAL PLASMA
6.

"Analysis of the DXD motifs in human xylosyltransferase I required for enzyme activity."
Goetting C. , Mueller S. , Schoettler M. , Schoen S. , Prante C. , Brinkmann T. , Kuhn J. , Kleesiek K.
J. Biol. Chem.279:42566-42573(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: BIOPHYSICOCHEMICAL PROPERTIES;COFACTOR;MUTAGENESIS OF ASP-314; ASP-316; ASP-745; TRP-746 AND ASP-747
7.

"Polymorphisms in the xylosyltransferase genes cause higher serum XT-I activity in patients with pseudoxanthoma elasticum (PXE) and are involved in a severe disease course."
Schon S. , Schulz V. , Prante C. , Hendig D. , Szliska C. , Kuhn J. , Kleesiek K. , Gotting C.
J. Med. Genet.43:745-749(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;VARIANTS SER-115; TRP-406 AND MET-665
8.

"XYLT1 mutations in Desbuquois dysplasia type 2."
Bui C. , Huber C. , Tuysuz B. , Alanay Y. , Bole-Feysot C. , Leroy J.G. , Mortier G. , Nitschke P. , Munnich A. , Cormier-Daire V.
Am. J. Hum. Genet.94:405-414(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT DBQD2 CYS-598
9.

"The missing 'link': an autosomal recessive short stature syndrome caused by a hypofunctional XYLT1 mutation."
Schreml J. , Durmaz B. , Cogulu O. , Keupp K. , Beleggia F. , Pohl E. , Milz E. , Coker M. , Ucar S.K. , Nurnberg G. , Nurnberg P. , Kuhn J. , Ozkinay F.
Hum. Genet.133:29-39(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT DBQD2 TRP-481

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