Gene name:
Yap1 (Yap;Yap65) ;
Protein name:
Yorkie homolog ;
Alternative:
65 kDa Yes-associated protein (YAP65) ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Binds to the SH3 domain of the YES kinase. Binds to WBP1 and WBP2. Binds, in vitro, through the WW1 domain, to neural isoforms of ENAH that contain the PPSY motif. The phosphorylated form interacts with YWHAB. Interacts (via WW domains) with LATS1 (via PPxY motif 2). Interacts with LATS2. Interacts (via WW domain 1) with isoform 2 of ERBB4 (via PPxY motif 2). Interacts with TEAD1, TEAD2, TEAD3 and TEAD4 (By similarity). Interacts with TP73 (By similarity). Interacts with RUNX1.
Function:
Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction (By similarity). Isoform 2, isoform 3 and isoform 4 (lacking the C-terminal transactivation domain) can attenuate p73-mediated cell death signaling in transcriptional repression-induced atypical death (TRIAD) of neurons.
Subcellular Location:
Cytoplasm
Nucleus
Both phosphorylation and cell density can regulate its subcellular localization. Phosphorylation sequesters it in the cytoplasm by inhibiting its translocation into the nucleus. At low density, predominantly nuclear and is translocated to the cytoplasm at high density.
Protein Attributes:
50:
MEPAQQPPPQ | PAPQGPAPPS | VSPAGTPAAP | PAPPAGHQVV | HVRGDSETDL |
100:
EALFNAVMNP | KTANVPQTVP | MRLRKLPDSF | FKPPEPKSHS | RQASTDAGTA |
150:
GALTPQHVRA | HSSPASLQLG | AGTLTASGVV | SGPAATPAAQ | HLRQSSFEIP |
200:
DDVPLPAGWE | MAKTSSGQRY | FLNHNDQTTT | WQDPRKAMLS | QLNVPTSASP |
250:
AVPQTLMNSA | SGPLPDGWEQ | AMTQDGEVYY | INHKNKTTSW | LDPRLDPRFA |
300:
MNQRITQSAP | VKQPPPLAPQ | SPQGGVLGGG | SSNQQQQIQL | QQLQMEKERL |
350:
RLKQQELFRQ | ELALRSQLPS | LEQDGGTQNA | VSSPGMTQEL | RTMTTNSSDP |
400:
FLNSGTYHSR | DESTDSGLSM | SSYSIPRTPD | DFLNSVDEMD | TGDTISQSTL |
450:
PSQQSRFPDY | LEALPGTNVD | LGTLEGDAMN | IEGEELMPSL | QEALSSEILD |
469:
VESVLAATKL | DKESFLTWL
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Rat
Chicken
ELISA Kit for Rat Yorkie homolog
ELISA Kit for Rat Yorkie homolog
ELISA Kit for Rat Yorkie homolog
ELISA Kit for Rat Yorkie homolog
CLIA Kit for Rat Yorkie homolog
CLIA Kit for Rat Yorkie homolog
CLIA Kit for Rat Yorkie homolog
CLIA Kit for Rat Yorkie homolog
Polyclonal Antibody for Rat Yorkie homolog
Polyclonal Antibody for Rat Yorkie homolog
Polyclonal Antibody for Rat Yorkie homolog
Polyclonal Antibody for Rat Yorkie homolog
Monoclonal Antibody for Rat Yorkie homolog
Monoclonal Antibody for Rat Yorkie homolog
Monoclonal Antibody for Rat Yorkie homolog
Monoclonal Antibody for Rat Yorkie homolog
Protein for Rat Yorkie homolog
Protein for Rat Yorkie homolog
Protein for Rat Yorkie homolog
Protein for Rat Yorkie homolog
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Transcriptional repression induces a slowly progressive atypical neuronal death associated with changes of YAP isoforms and p73."
Hoshino M.
,
Qi M.-L.
,
Yoshimura N.
,
Tagawa K.
,
Wada Y.-I.
,
Enokido Y.
,
Marubuchi S.
,
Harjes P.
,
Arai N.
,
Oyanagi K.
,
Blandino G.
,
Sudol M.
,
Rich T.
,
Kanazawa I.
,
Wanker E.E.
,
Saitoe M.
,
Okazawa H.
J. Cell Biol.172:589-604(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4);FUNCTION;INDUCTION;TISSUE SPECIFICITY
strain :
Wistar .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-94 AND THR-95;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]