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Index > Protein center > Yes1(Gene name) > Rat
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  • Yes1 (Gene name),
  • Tyrosine-protein kinase Yes (Protein name ),  YES_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Yes1;
    Protein name:
    Tyrosine-protein kinase Yes;
    Alternative:
    p61-Yes;
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Interacts with YAP1 and CSF1R (By similarity). Interacts with FASLG (By similarity). Interacts with CTNND1; this interaction allows YES1-mediated activation of FYN and FER and subsequent phosphorylation of CTNND1.
    Function:
    Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis.
    Subcellular Location:
    Cell membrane Cytoplasm Cytoskeleton Microtubule organizing center Centrosome Cytoplasm Cytosol Newly synthesized protein initially accumulates in the Golgi region and traffics to the plasma membrane through the exocytic pathway.
    Protein Attributes:
    Sequence length:
    541
    Sequence:
    50:
    MGCIKSKENK | SPAIKYTPEN | PTEPVNTSAG | HYGVEHATAA | TTSSTKGASA | 
    100:
    NFNSLSMTPF | GGSSGVTPFG | GASSSFSVVP | SSYPTSLTGG | VTIFVALYDY | 
    150:
    EARTTEDLSF | KKGERFQIIN | NTEGDWWEAR | SIATGKNGYI | PSNYVAPADS | 
    200:
    IQAEEWYFGK | MGRKDAERLL | LNPGNQRGIF | LVRESETTKG | AYSLSIRDWD | 
    250:
    EVRGDNVKHY | KIRKLDNGGY | YITTRAQFDT | LQKLVKHYTE | HADGLCHKLT | 
    300:
    TVCPTVKPQT | QGLAKDAWEI | PRESLRLEVK | LGQGCFGEVW | MGTWNGTTKV | 
    350:
    AIKTLKPGTM | MPEAFLQEAQ | IMKKLRHDKL | VPLYAVVSEE | PIYIVTEFMS | 
    400:
    KGILLDFLKE | GDGKYLKLPQ | LVDMAAQIAD | GMAYIERMNY | IHRDLRAANI | 
    450:
    LVGENLVCKI | ADFGLARLIE | DNEYTARQGA | KFPIKWTAPE | AALYGRFTIK | 
    500:
    SDVWSFGILQ | TELVTKGRVP | YPGMVNREVL | EQVERGYRMP | CPQGCPESLH | 
    541:
    ELMNLCWKKD | PDERPTFEYI | QSFLEDYFTA | TEPQYQPGEN | L
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Tyrosine-protein kinase Yes
    ELISA Kit for Rat Tyrosine-protein kinase Yes
    ELISA Kit for Rat Tyrosine-protein kinase Yes
    ELISA Kit for Rat Tyrosine-protein kinase Yes
    ELISA Kit for Rat Tyrosine-protein kinase Yes
    CLIA Kit for Rat Tyrosine-protein kinase Yes
    CLIA Kit for Rat Tyrosine-protein kinase Yes
    CLIA Kit for Rat Tyrosine-protein kinase Yes
    CLIA Kit for Rat Tyrosine-protein kinase Yes
    CLIA Kit for Rat Tyrosine-protein kinase Yes
    Polyclonal Antibody for Rat Tyrosine-protein kinase Yes
    Polyclonal Antibody for Rat Tyrosine-protein kinase Yes
    Polyclonal Antibody for Rat Tyrosine-protein kinase Yes
    Polyclonal Antibody for Rat Tyrosine-protein kinase Yes
    Polyclonal Antibody for Rat Tyrosine-protein kinase Yes
    Monoclonal Antibody for Rat Tyrosine-protein kinase Yes
    Monoclonal Antibody for Rat Tyrosine-protein kinase Yes
    Monoclonal Antibody for Rat Tyrosine-protein kinase Yes
    Monoclonal Antibody for Rat Tyrosine-protein kinase Yes
    Monoclonal Antibody for Rat Tyrosine-protein kinase Yes
    Protein for Rat Tyrosine-protein kinase Yes
    Protein for Rat Tyrosine-protein kinase Yes
    Protein for Rat Tyrosine-protein kinase Yes
    Protein for Rat Tyrosine-protein kinase Yes
    Protein for Rat Tyrosine-protein kinase Yes

    R&D Technical Data
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    Precision
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    Linearity
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    References
    1. 1.
      "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Gibbs R.A. , Weinstock G.M. , Metzker M.L. , Muzny D.M. , Sodergren E.J. , Scherer S. , Scott G. , Steffen D. , Worley K.C. , Burch P.E. , Okwuonu G. , Hines S. , Lewis L. , Deramo C. , Delgado O. , Dugan-Rocha S. , Miner G. , Morgan M. , more...
      Nature428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: Brown Norway.
    2. 2.
      "Specific proto-oncogenic tyrosine kinases of src family are enriched in cell-to-cell adherens junctions where the level of tyrosine phosphorylation is elevated."
      Tsukita S. , Oishi K. , Akiyama T. , Yamanashi Y. , Yamamoto T. , Tsukita S.
      J. Cell Biol.113:867-879(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    3. 3.
      "p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction."
      Piedra J. , Miravet S. , Castano J. , Palmer H.G. , Heisterkamp N. , Garcia de Herreros A. , Dunach M.
      Mol. Cell. Biol.23:2287-2297(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CTNND1
    4. 4.
      "c-Yes regulates cell adhesion at the blood-testis barrier and the apical ectoplasmic specialization in the seminiferous epithelium of rat testes."
      Xiao X. , Mruk D.D. , Lee W.M. , Cheng C.Y.
      Int. J. Biochem. Cell Biol.43:651-665(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
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