Protein name:
Tyrosine-protein kinase Yes ;
Alternative:
p61-Yes ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Interacts with YAP1 and CSF1R (By similarity). Interacts with FASLG (By similarity). Interacts with CTNND1; this interaction allows YES1-mediated activation of FYN and FER and subsequent phosphorylation of CTNND1.
Function:
Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis.
Subcellular Location:
Cell membrane
Cytoplasm
Cytoskeleton
Microtubule organizing center
Centrosome
Cytoplasm
Cytosol
Newly synthesized protein initially accumulates in the Golgi region and traffics to the plasma membrane through the exocytic pathway.
Protein Attributes:
50:
MGCIKSKENK | SPAIKYTPEN | PTEPVNTSAG | HYGVEHATAA | TTSSTKGASA |
100:
NFNSLSMTPF | GGSSGVTPFG | GASSSFSVVP | SSYPTSLTGG | VTIFVALYDY |
150:
EARTTEDLSF | KKGERFQIIN | NTEGDWWEAR | SIATGKNGYI | PSNYVAPADS |
200:
IQAEEWYFGK | MGRKDAERLL | LNPGNQRGIF | LVRESETTKG | AYSLSIRDWD |
250:
EVRGDNVKHY | KIRKLDNGGY | YITTRAQFDT | LQKLVKHYTE | HADGLCHKLT |
300:
TVCPTVKPQT | QGLAKDAWEI | PRESLRLEVK | LGQGCFGEVW | MGTWNGTTKV |
350:
AIKTLKPGTM | MPEAFLQEAQ | IMKKLRHDKL | VPLYAVVSEE | PIYIVTEFMS |
400:
KGILLDFLKE | GDGKYLKLPQ | LVDMAAQIAD | GMAYIERMNY | IHRDLRAANI |
450:
LVGENLVCKI | ADFGLARLIE | DNEYTARQGA | KFPIKWTAPE | AALYGRFTIK |
500:
SDVWSFGILQ | TELVTKGRVP | YPGMVNREVL | EQVERGYRMP | CPQGCPESLH |
541:
ELMNLCWKKD | PDERPTFEYI | QSFLEDYFTA | TEPQYQPGEN | L
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Dog
Rat
Human
Chicken
Mouse
ELISA Kit for Rat Tyrosine-protein kinase Yes
ELISA Kit for Rat Tyrosine-protein kinase Yes
ELISA Kit for Rat Tyrosine-protein kinase Yes
ELISA Kit for Rat Tyrosine-protein kinase Yes
ELISA Kit for Rat Tyrosine-protein kinase Yes
CLIA Kit for Rat Tyrosine-protein kinase Yes
CLIA Kit for Rat Tyrosine-protein kinase Yes
CLIA Kit for Rat Tyrosine-protein kinase Yes
CLIA Kit for Rat Tyrosine-protein kinase Yes
CLIA Kit for Rat Tyrosine-protein kinase Yes
Polyclonal Antibody for Rat Tyrosine-protein kinase Yes
Polyclonal Antibody for Rat Tyrosine-protein kinase Yes
Polyclonal Antibody for Rat Tyrosine-protein kinase Yes
Polyclonal Antibody for Rat Tyrosine-protein kinase Yes
Polyclonal Antibody for Rat Tyrosine-protein kinase Yes
Monoclonal Antibody for Rat Tyrosine-protein kinase Yes
Monoclonal Antibody for Rat Tyrosine-protein kinase Yes
Monoclonal Antibody for Rat Tyrosine-protein kinase Yes
Monoclonal Antibody for Rat Tyrosine-protein kinase Yes
Monoclonal Antibody for Rat Tyrosine-protein kinase Yes
Protein for Rat Tyrosine-protein kinase Yes
Protein for Rat Tyrosine-protein kinase Yes
Protein for Rat Tyrosine-protein kinase Yes
Protein for Rat Tyrosine-protein kinase Yes
Protein for Rat Tyrosine-protein kinase Yes
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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more...
Nature428:493-521(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
Brown Norway .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH CTNND1
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION