YEATS domain-containing protein 4 (Protein name
), YETS4_HUMAN from NCBI database.
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General Annotation
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Gene name:
YEATS4(GAS41);
Protein name:
YEATS domain-containing protein 4;
Alternative:
NuMA-binding protein 1(NuBI-1;NuBI1);Glioma-amplified sequence 41(Gas41);
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Component of numerous complexes with chromatin remodeling and histone acetyltransferase activity. Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC and the adenovirus E1A protein. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. YEATS4 interacts with MLLT10/AF10. YEATS4 may also interact with the SWI/SNF component SMARCB1/BAF47, TACC1 and TACC2, and the nuclear matrix protein NUMA1.
Function:
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.
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Cited for: NUCLEOTIDE SEQUENCE [MRNA];SUBCELLULAR LOCATION;INTERACTION WITH NUMA1;TISSUE SPECIFICITY
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Cited for: PROTEIN SEQUENCE OF 5-15; 18-32; 56-64; 120-131; 168-178 AND 217-227;IDENTIFICATION IN NUA4 COMPLEX;IDENTIFICATION BY MASS SPECTROMETRY
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Cited for: FUNCTION;IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN NUA4 COMPLEX;IDENTIFICATION IN NUA4-RELATED SRCAP-CONTAINING COMPLEX
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Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
Vaild Sequence:
