Protein name:
YEATS domain-containing protein 4 ;
Alternative:
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Component of numerous complexes with chromatin remodeling and histone acetyltransferase activity. Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. YEATS4 interacts with MLLT10/AF10. YEATS4 may also interact with the SWI/SNF component SMARCB1/BAF47, TACC1 and TACC2, and the nuclear matrix protein NUMA1.
Function:
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MFKRMAEFGP | DSGGRVKGVT | IVKPIVYGNV | ARYFGKKREE | DGHTHQWTVY |
100:
VKPYRNEDMS | AYVKKIQFKL | HESYGNPLRV | VTKPPYEITE | TGWGEFEIII |
150:
KIFFIDPNER | PVTLYHLLKL | FQSDTNAMLG | KKTVVSEFYD | EMIFQDPTAM |
200:
MQQLLTTSRQ | LTLGAYKHET | EFAELEVKTR | EKLEAAKKKT | SFEIAELKER |
227:
LKASRETINC | LKNEIRKLEE | DDQTKDI
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
ELISA Kit for Mouse YEATS domain-containing protein 4
ELISA Kit for Mouse YEATS domain-containing protein 4
CLIA Kit for Mouse YEATS domain-containing protein 4
CLIA Kit for Mouse YEATS domain-containing protein 4
Polyclonal Antibody for Mouse YEATS domain-containing protein 4
Polyclonal Antibody for Mouse YEATS domain-containing protein 4
Monoclonal Antibody for Mouse YEATS domain-containing protein 4
Monoclonal Antibody for Mouse YEATS domain-containing protein 4
Protein for Mouse YEATS domain-containing protein 4
Protein for Mouse YEATS domain-containing protein 4
R&D Technical Data
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Precision
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Recovery
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Linearity
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6J .
tissue :
Kidney .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
Czech II .
tissue :
Mammary tumor .