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Index > Protein center > ZFP57(Gene name) > Human
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  • ZFP57 (Gene name),
  • Zinc finger protein 57 homolog (Protein name ),  ZFP57_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    ZFP57(C6orf40;ZNF698);
    Protein name:
    Zinc finger protein 57 homolog(Zfp-57);
    Alternative:
    Zinc finger protein 698;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions. Required for the establishment of maternal methylation imprints at SNRPN locus. Acts as a transcriptional repressor in Schwann cells.
    Subcellular Location:
    Nucleus Binds various differentially methylated regions (DMR), including the SNRPN DMR.
    Protein Attributes:
    Sequence length:
    452
    Sequence:
    50:
    MAAGEPRSLL | FFQKPVTFED | VAVNFTQEEW | DCLDASQRVL | YQDVMSETFK | 
    100:
    NLTSVARIFL | HKPELITKLE | QEEEQWRETR | VLQASQAGPP | FFCYTCGKCF | 
    150:
    SRRSYLYSHQ | FVHNPKLTNS | CSQCGKLFRS | PKSLSYHRRM | HLGERPFCCT | 
    200:
    LCDKTYCDAS | GLSRHRRVHL | GYRPHSCSVC | GKSFRDQSEL | KRHQKIHQNQ | 
    250:
    EPVDGNQECT | LRIPGTQAEF | QTPIARSQRS | IQGLLDVNHA | PVARSQEPIF | 
    300:
    RTEGPMAQNQ | ASVLKNQAPV | TRTQAPITGT | LCQDARSNSH | PVKPSRLNVF | 
    350:
    CCPHCSLTFS | KKSYLSRHQK | AHLTEPPNYC | FHCSKSFSSF | SRLVRHQQTH | 
    400:
    WKQKSYLCPI | CDLSFGEKEG | LMDHWRGYKG | KDLCQSSHHK | CRVILGQWLG | 
    450:
    FSHDVPTMAG | EEWKHGGDQS | PPRIHTPRRR | GLREKACKGD | KTKEAVSILK | 
    452:
    HK
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    UniGene:
    Pfam:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Zfp-57
    ELISA Kit for Human Zfp-57
    ELISA Kit for Human Zfp-57
    CLIA Kit for Human Zfp-57
    CLIA Kit for Human Zfp-57
    CLIA Kit for Human Zfp-57
    Polyclonal Antibody for Human Zfp-57
    Polyclonal Antibody for Human Zfp-57
    Polyclonal Antibody for Human Zfp-57
    Monoclonal Antibody for Human Zfp-57
    Monoclonal Antibody for Human Zfp-57
    Monoclonal Antibody for Human Zfp-57
    Protein for Human Zfp-57
    Protein for Human Zfp-57
    Protein for Human Zfp-57

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT VAL-284
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
    3. 3.
      "Hypomethylation of multiple imprinted loci in individuals with transient neonatal diabetes is associated with mutations in ZFP57."
      Mackay D.J.G. , Callaway J.L.A. , Marks S.M. , White H.E. , Acerini C.L. , Boonen S.E. , Dayanikli P. , Firth H.V. , Goodship J.A. , Haemers A.P. , Hahnemann J.M.D. , Kordonouri O. , Masoud A.F. , Oestergaard E. , Storr J. , Ellard S. , Hattersley A.T. , Robinson D.O. , more...
      Nat. Genet.40:949-951(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS TNDM1 HIS-166; ASN-193 AND ASP-374;FUNCTION
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