ZFYVE9 ELISA Kit for Human(Homo sapiens) | EIAab.comZFYVE9 ELISA Kit for Human(Homo sapiens) | EIAab.com

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ZFYVE9 (Gene name),

Zinc finger FYVE domain-containing protein 9 (Protein name ), ZFYV9_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Gene name:

ZFYVE9(MADHIP;SARA;SMADIP);

Protein name:

Zinc finger FYVE domain-containing protein 9;

Alternative:

Novel serine protease(NSP);Mothers against decapentaplegic homolog-interacting protein(Madh-interacting protein);Smad anchor for receptor activation;Receptor activation anchor(hSARA);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts (via the SBD region) with SMAD2; the interaction recruits SMAD2 to the TGF-beta receptor and is disrupted by phosphorylation of SMAD2 upon TGF-beta receptor activation. Interacts with SMAD3. Interacts with TGFBR1 and TGFBR2; the interaction recruits SMAD2 to the TGF-beta receptor. Interacts with PML.

Function:

Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization.

Subcellular Location:

Cytoplasm Early endosome membrane

Protein Attributes:

Sequence length:

1425

Sequence:

50:

MENYFQAEAY | NLDKVLDEFE | QNEDETVSST | LLDTKWNKIL | DPPSHRLSFN |

100:

PTLASVNESA | VSNESQPQLK | VFSLAHSAPL | TTEEEDHCAN | GQDCNLNPEI |

150:

ATMWIDENAV | AEDQLIKRNY | SWDDQCSAVE | VGEKKCGNLA | CLPDEKNVLV |

200:

VAVMHNCDKR | TLQNDLQDCN | NYNSQSLMDA | FSCSLDNENR | QTDQFSFSIN |

250:

ESTEKDMNSE | KQMDPLNRPK | TEGRSVNHLC | PTSSDSLASV | CSPSQLKDDG |

300:

SIGRDPSMSA | ITSLTVDSVI | SSQGTDGCPA | VKKQENYIPD | EDLTGKISSP |

350:

RTDLGSPNSF | SHMSEGILMK | KEPAEESTTE | ESLRSGLPLL | LKPDMPNGSG |

400:

RNNDCERCSD | CLVPNEVRAD | ENEGYEHEET | LGTTEFLNMT | EHFSESQDMT |

450:

NWKLTKLNEM | NDSQVNEEKE | KFLQISQPED | TNGDSGGQCV | GLADAGLDLK |

500:

GTCISESEEC | DFSTVIDTPA | ANYLSNGCDS | YGMQDPGVSF | VPKTLPSKED |

550:

SVTEEKEIEE | SKSECYSNIY | EQRGNEATEG | SGLLLNSTGD | LMKKNYLHNF |

600:

CSQVPSVLGQ | SSPKVVASLP | SISVPFGGAR | PKQPSNLKLQ | IPKPLSDHLQ |

650:

NDFPANSGNN | TKNKNDILGK | AKLGENSATN | VCSPSLGNIS | NVDTNGEHLE |

700:

SYEAEISTRP | CLALAPDSPD | NDLRAGQFGI | SARKPFTTLG | EVAPVWVPDS |

750:

QAPNCMKCEA | RFTFTKRRHH | CRACGKVFCA | SCCSLKCKLL | YMDRKEARVC |

800:

VICHSVLMNA | QAWENMMSAS | SQSPNPNNPA | EYCSTIPPLQ | QAQASGALSS |

850:

PPPTVMVPVG | VLKHPGAEVA | QPREQRRVWF | ADGILPNGEV | ADAAKLTMNG |

900:

TSSAGTLAVS | HDPVKPVTTS | PLPAETDICL | FSGSITQVGS | PVGSAMNLIP |

950:

EDGLPPILIS | TGVKGDYAVE | EKPSQISVMQ | QLEDGGPDPL | VFVLNANLLS |

1000:

MVKIVNYVNR | KCWCFTTKGM | HAVGQSEIVI | LLQCLPDEKC | LPKDIFNHFV |

1050:

QLYRDALAGN | VVSNLGHSFF | SQSFLGSKEH | GGFLYVTSTY | QSLQDLVLPT |

1100:

PPYLFGILIQ | KWETPWAKVF | PIRLMLRLGA | EYRLYPCPLF | SVRFRKPLFG |

1150:

ETGHTIMNLL | ADFRNYQYTL | PVVQGLVVDM | EVRKTSIKIP | SNRYNEMMKA |

1200:

MNKSNEHVLA | GGACFNEKAD | SHLVCVQNDD | GNYQTQAISI | HNQPRKVTGA |

1250:

SFFVFSGALK | SSSGYLAKSS | IVEDGVMVQI | TAENMDSLRQ | ALREMKDFTI |

1300:

TCGKADAEEP | QEHIHIQWVD | DDKNVSKGVV | SPIDGKSMET | ITNVKIFHGS |

1350:

EYKANGKVIR | WTEVFFLEND | DQHNCLSDPA | DHSRLTEHVA | KAFCLALCPH |

1400:

LKLLKEDGMT | KLGLRVTLDS | DQVGYQAGSN | GQPLPSQYMN | DLDSALVPVI |

1425:

HGGACQLSEG | PVVMELIFYI | LENIV

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

String:

UniGene:

SMR:

KEGG:

MIM:

STRING:

9606.ENSP00000287727

Uniprot:

FOR

ELISA Kit for Human Zinc finger FYVE domain-containing protein 9

CLIA Kit for Human Zinc finger FYVE domain-containing protein 9

Polyclonal Antibody for Human Zinc finger FYVE domain-containing protein 9

Monoclonal Antibody for Human Zinc finger FYVE domain-containing protein 9

Protein for Human Zinc finger FYVE domain-containing protein 9

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

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Recovery

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Linearity

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

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References

1.

"SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor."
Tsukazaki T. , Chiang T.A. , Davison A.F. , Attisano L. , Wrana J.L.
Cell95:779-791(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INTERACTION WITH SMAD2; SMAD3; TGFBR1 AND TGFBR2;FUNCTION;SUBCELLULAR LOCATION
2.

"Identification of a novel serine protease-like molecule in human brain."
Meckelein B. , Marshall D.C.L. , Conn K.J. , Pietropaolo M. , Van Nostrand W. , Abraham C.R.
Brain Res. Mol. Brain Res.55:181-197(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3)
tissue: Fetal brain.
3.

"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Testis.
6.

"Early endosomal regulation of Smad-dependent signaling in endothelial cells."
Panopoulou E. , Gillooly D.J. , Wrana J.L. , Zerial M. , Stenmark H. , Murphy C. , Fotsis T.
J. Biol. Chem.277:18046-18052(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
7.

"An unappreciated role for RNA surveillance."
Hillman R.T. , Green R.E. , Brenner S.E.
Genome Biol.5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S)
8.

"Cytoplasmic PML function in TGF-beta signalling."
Lin H.K. , Bergmann S. , Pandolfi P.P.
Nature431:205-211(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH PML; SMAD2 AND SMAD3
9.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
10.

"Structural basis of Smad2 recognition by the Smad anchor for receptor activation."
Wu G. , Chen Y.-G. , Ozdamar B. , Gyuricza C.A. , Chong P.A. , Wrana J.L. , Massague J. , Shi Y.
Science287:92-97(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 771-811 IN COMPLEX WITH SMAD2;MUTAGENESIS
11.

"Smad3 allostery links TGF-beta receptor kinase activation to transcriptional control."
Qin B.Y. , Lam S.S. , Correia J.J. , Lin K.
Genes Dev.16:1950-1963(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.74 ANGSTROMS) OF 773-810 IN COMPLEX WITH SMAD3

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