Gene name:
ZRANB1 (TRABID) ;
Protein name:
Ubiquitin thioesterase ZRANB1 ;
Alternative:
hTrabid ;Zinc finger Ran-binding domain-containing protein 1 (hTrabid) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with APC and TRAF6.
Function:
Positive regulator of the Wnt signaling pathway that specifically cleaves 'Lys-63'-linked ubiquitin chains. Acts by deubiquitinating APC protein, a negative regulator of Wnt-mediated transcription. May also modulate TNF-alpha signaling.
Subcellular Location:
Cytoplasm
Nucleus
Protein Attributes:
50:
MSERGIKWAC | EYCTYENWPS | AIKCTMCRAQ | RPSGTIITED | PFKSGSSDVG |
100:
RDWDPSSTEG | GSSPLICPDS | SARPRVKSSY | SMENANKWSC | HMCTYLNWPR |
150:
AIRCTQCLSQ | RRTRSPTESP | QSSGSGSRPV | AFSVDPCEEY | NDRNKLNTRT |
200:
QHWTCSVCTY | ENWAKAKRCV | VCDHPRPNNI | EAIELAETEE | ASSIINEQDR |
250:
ARWRGSCSSG | NSQRRSPPAT | KRDSEVKMDF | QRIELAGAVG | SKEELEVDFK |
300:
KLKQIKNRMK | KTDWLFLNAC | VGVVEGDLAA | IEAYKSSGGD | IARQLTADEV |
350:
RLLNRPSAFD | VGYTLVHLAI | RFQRQDMLAI | LLTEVSQQAA | KCIPAMVCPE |
400:
LTEQIRREIA | ASLHQRKGDF | ACYFLTDLVT | FTLPADIEDL | PPTVQEKLFD |
450:
EVLDRDVQKE | LEEESPIINW | SLELATRLDS | RLYALWNRTA | GDCLLDSVLQ |
500:
ATWGIYDKDS | VLRKALHDSL | HDCSHWFYTR | WKDWESWYSQ | SFGLHFSLRE |
550:
EQWQEDWAFI | LSLASQPGAS | LEQTHIFVLA | HILRRPIIVY | GVKYYKSFRG |
600:
ETLGYTRFQG | VYLPLLWEQS | FCWKSPIALG | YTRGHFSALV | AMENDGYGNR |
650:
GAGANLNTDD | DVTITFLPLV | DSERKLLHVH | FLSAQELGNE | EQQEKLLREW |
700:
LDCCVTEGGV | LVAMQKSSRR | RNHPLVTQMV | EKWLDRYRQI | RPCTSLSDGE |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Bovine
Human
Mouse
ELISA Kit for Human Ubiquitin thioesterase ZRANB1
ELISA Kit for Human Ubiquitin thioesterase ZRANB1
ELISA Kit for Human Ubiquitin thioesterase ZRANB1
CLIA Kit for Human Ubiquitin thioesterase ZRANB1
CLIA Kit for Human Ubiquitin thioesterase ZRANB1
CLIA Kit for Human Ubiquitin thioesterase ZRANB1
Polyclonal Antibody for Human Ubiquitin thioesterase ZRANB1
Polyclonal Antibody for Human Ubiquitin thioesterase ZRANB1
Polyclonal Antibody for Human Ubiquitin thioesterase ZRANB1
Monoclonal Antibody for Human Ubiquitin thioesterase ZRANB1
Monoclonal Antibody for Human Ubiquitin thioesterase ZRANB1
Monoclonal Antibody for Human Ubiquitin thioesterase ZRANB1
Protein for Human Ubiquitin thioesterase ZRANB1
Protein for Human Ubiquitin thioesterase ZRANB1
Protein for Human Ubiquitin thioesterase ZRANB1
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Testis .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 151-708
tissue :
Melanoma .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH APC;DOMAIN;MUTAGENESIS OF CYS-10; 14-THR-TYR-15; CYS-90; 94-THR-TYR-95; CYS-155; 159-THR-TYR-160 AND CYS-443
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[
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION
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Cell154:169-184(2013)
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[
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[
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;CATALYTIC ACTIVITY
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Nat. Struct. Mol. Biol.19:62-71(2012)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.23 ANGSTROMS) OF 245-697;FUNCTION;LINKAGE SPECIFICITY;ACTIVE SITE;DOMAIN ANK REPEATS