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Index > Protein center > ZWINT(Gene name) > Human
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  • ZWINT (Gene name),
  • ZW10 interactor (Protein name ),  ZWINT_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    ZWINT;
    Protein name:
    ZW10 interactor;
    Alternative:
    ZW10-interacting protein 1(Zwint-1);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with ZW10 and MIS12. Interacts with the NDC80 subunit of the NDC80 complex specifically during mitosis. Also interacts with CASC5, CETN3, DSN1 and PMF1.
    Function:
    Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase.
    Subcellular Location:
    Nucleus Chromosome centromere kinetochore Localizes to kinetochores from late prophase to anaphase.
    Protein Attributes:
    Sequence length:
    277
    Sequence:
    50:
    MEAAETEAEA | AALEVLAEVA | GILEPVGLQE | EAELPAKILV | EFVVDSQKKD | 
    100:
    KLLCSQLQVA | DFLQNILAQE | DTAKGLDPLA | SEDTSRQKAI | AAKEQWKELK | 
    150:
    ATYREHVEAI | KIGLTKALTQ | MEEAQRKRTQ | LREAFEQLQA | KKQMAMEKRR | 
    200:
    AVQNQWQLQQ | EKHLQHLAEV | SAEVRERKTG | TQQELDRVFQ | KLGNLKQQAE | 
    250:
    QERDKLQRYQ | TFLQLLYTLQ | GKLLFPEAEA | EAENLPDDKP | QQPTRPQEQS | 
    277:
    TGDTMGRDPG | VSFKAVGLQP | AGDVNLP
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    UniGene:
    KEGG:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human ZW10 interactor
    ELISA Kit for Human ZW10 interactor
    ELISA Kit for Human ZW10 interactor
    ELISA Kit for Human ZW10 interactor
    CLIA Kit for Human ZW10 interactor
    CLIA Kit for Human ZW10 interactor
    CLIA Kit for Human ZW10 interactor
    CLIA Kit for Human ZW10 interactor
    Polyclonal Antibody for Human ZW10 interactor
    Polyclonal Antibody for Human ZW10 interactor
    Polyclonal Antibody for Human ZW10 interactor
    Polyclonal Antibody for Human ZW10 interactor
    Monoclonal Antibody for Human ZW10 interactor
    Monoclonal Antibody for Human ZW10 interactor
    Monoclonal Antibody for Human ZW10 interactor
    Monoclonal Antibody for Human ZW10 interactor
    Protein for Human ZW10 interactor
    Protein for Human ZW10 interactor
    Protein for Human ZW10 interactor
    Protein for Human ZW10 interactor

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "HZwint-1, a novel human kinetochore component that interacts with HZW10."
      Starr D.A. , Saffery R. , Li Z. , Simpson A.E. , Choo K.H. , Yen T.J. , Goldberg M.L.
      J. Cell Sci.113:1939-1950(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT GLY-187
    2. 2.
      "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
      Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT GLY-187
      tissue: Colon.
      tissue: Lymph.
      tissue: Muscle.
    4. 4.
      "Recapitulation of the Roberts syndrome cellular phenotype by inhibition of INCENP, ZWINT-1 and ZW10 genes."
      Musio A. , Mariani T. , Montagna C. , Zambroni D. , Ascoli C. , Ried T. , Vezzoni P.
      Gene331:33-40(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    5. 5.
      "Human Zwint-1 specifies localization of Zeste White 10 to kinetochores and is essential for mitotic checkpoint signaling."
      Wang H. , Hu X. , Ding X. , Dou Z. , Yang Z. , Shaw A.W. , Teng M. , Cleveland D.W. , Goldberg M.L. , Niu L. , Yao X.
      J. Biol. Chem.279:54590-54598(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH ZW10;SUBCELLULAR LOCATION
    6. 6.
      "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1."
      Obuse C. , Iwasaki O. , Kiyomitsu T. , Goshima G. , Toyoda Y. , Yanagida M.
      Nat. Cell Biol.6:1135-1141(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;INTERACTION WITH MIS12;SUBCELLULAR LOCATION
    7. 7.
      "ZW10 links mitotic checkpoint signaling to the structural kinetochore."
      Kops G.J.P.L. , Kim Y. , Weaver B.A.A. , Mao Y. , McLeod I. , Yates J.R. III , Tagaya M. , Cleveland D.W.
      J. Cell Biol.169:49-60(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;IDENTIFICATION BY MASS SPECTROMETRY;INTERACTION WITH CASC5; CETN3; DSN1; NDC80; MIS12; PMFF1 AND ZW10;SUBCELLULAR LOCATION
    8. 8.
      "Hec1 sequentially recruits Zwint-1 and ZW10 to kinetochores for faithful chromosome segregation and spindle checkpoint control."
      Lin Y.-T. , Chen Y. , Wu G. , Lee W.-H.
      Oncogene25:6901-6914(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH NDC80 AND ZW10;SUBCELLULAR LOCATION
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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