A Combination of Grape Extract, Green Tea Extract and l‐Carnitine Improves High‐fat Diet‐induced Obesity, Hyperlipidemia and Non‐alcoholic Fatty Liver Disease in Mice

ABSTRACT 

To develop a therapeutic agent for obesity‐related metabolic disorders, a mixture of dietary components was prepared, including grape extract, green tea extract and L‐carnitine (RGTC), and its effects on obesity, hyperlipidemia and non‐alcoholic fatty liver disease examined. The RGTC dramatically inhibited the high‐fat diet (HFD)‐induced increase in body weight and fat in C57BL/6 mice, whereas food consumption was not affected by RGTC treatment. The RGTC also concentration‐dependently suppressed the HFD‐induced increase in plasma lipids, such as low‐density lipoprotein cholesterol and triglycerides. In addition, increases in liver weight and liver steatosis were returned to normal by RGTC treatment in HFD‐fed C57BL/6 mice. The plasma levels of glutamic‐oxaloacetic transaminase and glutamic‐pyruvic transaminase were also significantly down‐regulated by RGTC treatment. These results suggest that RGTC suppressed HFD‐induced obesity,hyperlipidemia and non‐alcoholic fatty liver disease, suggesting that RGTC supplementation might be a promising adjuvant therapy for the treatment of these metabolic disorders.