Abstract
Background
Plasma gelsolin is a circulating actin-binding protein that has a protective role against tissue injuries. Our aim was to compare the baseline levels of gelsolin in premature infants with neonatal outcomes.
Method
A total of 32 preterm neonates born at 23-32 weeks of gestation were enrolled to the study.
Results
Plasma gelsolin levels at 72 hours were significantly lower in patients with RDS, in patients who were administered surfactant therapy and in patients who developed sepsis ( p< 0.05). PSGN levels at 28 days were significantly lower in patients who developed BPD and ROP ( p<0.05).
Conclusions
Low serum gelsolin levels in the first postnatal month may be associated with outcomes in premature infants.
