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木香对溃疡性结肠炎大鼠干预作用的影响
Update time:2016-12-12 18:51:00   【 Font: Large  Medium Small

摘要

目的
通过探讨木香对溃疡性结肠炎(ulcerative colitis, UC)大鼠的干预作用机制, 阐释胃肠安丸"芳香化浊"药物作用靶点.

方法
清洁级Wistar♂大鼠40只随机分为4组, 分别为空白对照组(N)、模型组(C)、中药饮片高、低剂量组(MX20、MX10)每组10只, 采用2,4,6-三硝基苯磺酸/乙醇混合液灌肠法诱导实验性UC, 空白对照组和模型组以蒸馏水灌胃, 中药组以木香水煎剂灌胃, 2 mL/只, 1次/d, 连续7 d. 观察UC大鼠疾病活动指数(disease activity index, DAI)、结肠黏膜损伤指数(colon macroscopic damage index, CMDI)及组织病理学变化、血清超氧化物歧化酶(superoxide dismutase, SOD)、血浆丙二醛(malondialdehyde, MDA)、前列腺素E2(prostaglandin E2, PGE2)、表皮生长因子(epidermal growth factor, EGF)含量及结肠肠三叶因子(intestinal trefoil factor, TFF3)表达.

结果
木香可有效减轻UC大鼠腹泻次数及黏液脓血便, 降低DAI、CMDI积分. 光镜下可见病变结肠上皮呈不同程度修复, 溃疡面积缩小. 血清SOD、EGF、结肠TFF3含量显著升高, 血浆MDA、PGE2含量显著性降低.

结论
木香对UC的干预作用是胃肠安丸芳香化浊作用机制的科学阐释.

关键词: 溃疡性结肠炎; 木香; 胃肠安丸; 大鼠

 

Cited products
Source:世界华人消化杂志      by 刘海荣, 马露, 唐方, 张勇, 杨瑾
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