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Index > Protein center > PRKAA2(Gene name) > Human
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  • PRKAA2 (Gene name),
  • 5'-AMP-activated protein kinase catalytic subunit alpha-2 (Protein name ),  AAPK2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Vaild Sequence
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  • Gene name:
    PRKAA2(AMPK;AMPK2);
    Protein name:
    5'-AMP-activated protein kinase catalytic subunit alpha-2(AMPK subunit alpha-2);
    Alternative:
    2.7.11.31;Hydroxymethylglutaryl-CoA reductase kinase(HMGCR kinase);2.7.11.27;Acetyl-CoA carboxylase kinase(ACACA kinase);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2.
    Function:
    Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively. Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3. AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160. Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A. Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm. In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription. Acts as a key regulator of cell growth and proliferation by phosphorylating TSC2, RPTOR and ATG1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2. In response to nutrient limitation, promotes autophagy by phosphorylating and activating ULK1. AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it. May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it. Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1.
    Subcellular Location:
    Cytoplasm Nucleus In response to stress, recruited by p53/TP53 to specific promoters.
    Protein Attributes:
    Sequence length:
    552
    Sequence:
    50:
    MAEKQKHDGR | VKIGHYVLGD | TLGVGTFGKV | KIGEHQLTGH | KVAVKILNRQ | 
    100:
    KIRSLDVVGK | IKREIQNLKL | FRHPHIIKLY | QVISTPTDFF | MVMEYVSGGE | 
    150:
    LFDYICKHGR | VEEMEARRLF | QQILSAVDYC | HRHMVVHRDL | KPENVLLDAH | 
    200:
    MNAKIADFGL | SNMMSDGEFL | RTSCGSPNYA | APEVISGRLY | AGPEVDIWSC | 
    250:
    GVILYALLCG | TLPFDDEHVP | TLFKKIRGGV | FYIPEYLNRS | VATLLMHMLQ | 
    300:
    VDPLKRATIK | DIREHEWFKQ | DLPSYLFPED | PSYDANVIDD | EAVKEVCEKF | 
    350:
    ECTESEVMNS | LYSGDPQDQL | AVAYHLIIDN | RRIMNQASEF | YLASSPPSGS | 
    400:
    FMDDSAMHIP | PGLKPHPERM | PPLIADSPKA | RCPLDALNTT | KPKSLAVKKA | 
    450:
    KWHLGIRSQS | KPYDIMAEVY | RAMKQLDFEW | KVVNAYHLRV | RRKNPVTGNY | 
    500:
    VKMSLQLYLV | DNRSYLLDFK | SIDDEVVEQR | SGSSTPQRSC | SAAGLHRPRS | 
    550:
    SFDSTTAESH | SLSGSLTGSL | TGSTLSSVSP | RLGSHTMDFF | EMCASLITTL | 
    552:
    AR
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    UniGene:
    SMR:
    Pfam:
    String:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human AMPK subunit alpha-2
    Cat.:
    E10189h
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    96T
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    ELISA Kit for Human AMPK subunit alpha-2
    Cat.:
    E10189p
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    96T
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    ELISA Kit for Human AMPK subunit alpha-2
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    E10189m
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    ELISA Kit for Human AMPK subunit alpha-2
    Cat.:
    E10189r
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    Packing:
    96T
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    CLIA Kit for Human AMPK subunit alpha-2
    MSDS:
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    CLIA Kit for Human AMPK subunit alpha-2
    Cat.:
    U10189h
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human AMPK subunit alpha-2
    Cat.:
    U10189r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human AMPK subunit alpha-2
    Cat.:
    U10189m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human AMPK subunit alpha-2
    Cat.:
    P10189Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human AMPK subunit alpha-2
    Polyclonal Antibody for Human AMPK subunit alpha-2
    Polyclonal Antibody for Human AMPK subunit alpha-2
    Monoclonal Antibody for Human AMPK subunit alpha-2
    Monoclonal Antibody for Human AMPK subunit alpha-2
    Monoclonal Antibody for Human AMPK subunit alpha-2
    Monoclonal Antibody for Human AMPK subunit alpha-2
    Protein for Human AMPK subunit alpha-2
    Protein for Human AMPK subunit alpha-2
    Protein for Human AMPK subunit alpha-2
    Protein for Human AMPK subunit alpha-2

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Characterization and chromosomal localization of the human homologue of a rat AMP-activated protein kinase-encoding gene: a major regulator of lipid metabolism in mammals."
      Aguan K. , Scott J. , See C.G. , Sarkar N.H.
      Gene149:345-350(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION
      tissue: Heart.
    2. 2.
      "Molecular cloning, expression and chromosomal localisation of human AMP-activated protein kinase."
      Beri R.K. , Marley A.E. , See C.G. , Sopwith W.F. , Aguan K. , Carling D. , Scott J. , Carey F.
      FEBS Lett.356:117-121(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Skeletal muscle.
    3. 3.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    5. 5.
      "Cell cycle regulation via p53 phosphorylation by a 5'-AMP activated protein kinase activator, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside, in a human hepatocellular carcinoma cell line."
      Imamura K. , Ogura T. , Kishimoto A. , Kaminishi M. , Esumi H.
      Biochem. Biophys. Res. Commun.287:562-567(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    6. 6.
      "Regulation of transcription by AMP-activated protein kinase: phosphorylation of p300 blocks its interaction with nuclear receptors."
      Yang W. , Hong Y.H. , Shen X.Q. , Frankowski C. , Camp H.S. , Leff T.
      J. Biol. Chem.276:38341-38344(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF EP300
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION
    8. 8.
      "Physiological modulation of CFTR activity by AMP-activated protein kinase in polarized T84 cells."
      Hallows K.R. , Kobinger G.P. , Wilson J.M. , Witters L.A. , Foskett J.K.
      Am. J. Physiol.284:C1297-C1308(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF CFTR
    9. 9.
      "TSC2 mediates cellular energy response to control cell growth and survival."
      Inoki K. , Zhu T. , Guan K.L.
      Cell115:577-590(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF TSC2
    10. 10.
      "The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases."
      Hurley R.L. , Anderson K.A. , Franzone J.M. , Kemp B.E. , Means A.R. , Witters L.A.
      J. Biol. Chem.280:29060-29066(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-172;ENZYME REGULATION
    11. 11.
      "AMP-activated protein kinase induces a p53-dependent metabolic checkpoint."
      Jones R.G. , Plas D.R. , Kubek S. , Buzzai M. , Mu J. , Xu Y. , Birnbaum M.J. , Thompson C.B.
      Mol. Cell18:283-293(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    12. 12.
      "The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor."
      Greer E.L. , Oskoui P.R. , Banko M.R. , Maniar J.M. , Gygi M.P. , Gygi S.P. , Brunet A.
      J. Biol. Chem.282:30107-30119(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF FOXO3
    13. 13.
      "Energy-dependent regulation of cell structure by AMP-activated protein kinase."
      Lee J.H. , Koh H. , Kim M. , Kim Y. , Lee S.Y. , Karess R.E. , Lee S.H. , Shong M. , Kim J.M. , Kim J. , Chung J.
      Nature447:1017-1020(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CELL POLARITY
    14. 14.
      "AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5."
      McGee S.L. , van Denderen B.J. , Howlett K.F. , Mollica J. , Schertzer J.D. , Kemp B.E. , Hargreaves M.
      Diabetes57:860-867(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF HDAC5
    15. 15.
      "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
      Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-377;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    16. 16.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    17. 17.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-377;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    18. 18.
      "Cell-wide analysis of secretory granule dynamics in three dimensions in living pancreatic beta-cells: evidence against a role for AMPK-dependent phosphorylation of KLC1 at Ser517/Ser520 in glucose-stimulated insulin granule movement."
      McDonald A. , Fogarty S. , Leclerc I. , Hill E.V. , Hardie D.G. , Rutter G.A.
      Biochem. Soc. Trans.38:205-208(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF KLC1
    19. 19.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    20. 20.
      "Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop."
      Loffler A.S. , Alers S. , Dieterle A.M. , Keppeler H. , Franz-Wachtel M. , Kundu M. , Campbell D.G. , Wesselborg S. , Alessi D.R. , Stork B.
      Autophagy7:696-706(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY ULK1
    21. 21.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    22. 22.
      "Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy."
      Egan D.F. , Shackelford D.B. , Mihaylova M.M. , Gelino S. , Kohnz R.A. , Mair W. , Vasquez D.S. , Joshi A. , Gwinn D.M. , Taylor R. , Asara J.M. , Fitzpatrick J. , Dillin A. , Viollet B. , Kundu M. , Hansen M. , Shaw R.J.
      Science331:456-461(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF ULK1
    23. 23.
      "AMP-activated protein kinase in metabolic control and insulin signaling."
      Towler M.C. , Hardie D.G.
      Circ. Res.100:328-341(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
    24. 24.
      "AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy."
      Hardie D.G.
      Nat. Rev. Mol. Cell Biol.8:774-785(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
    25. 25.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION BY SALICYLATE
    26. 26.
      "N-Myristoylation is essential for protein phosphatases PPM1A and PPM1B to dephosphorylate their physiological substrates in cells."
      Chida T. , Ando M. , Matsuki T. , Masu Y. , Nagaura Y. , Takano-Yamamoto T. , Tamura S. , Kobayashi T.
      Biochem. J.449:741-749(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEPHOSPHORYLATION AT THR-172
    27. 27.
      "A conserved mechanism of autoinhibition for the AMPK kinase domain: ATP-binding site and catalytic loop refolding as a means of regulation."
      Littler D.R. , Walker J.R. , Davis T. , Wybenga-Groot L.E. , Finerty P.J. Jr. , Newman E. , Mackenzie F. , Dhe-Paganon S.
      Acta Crystallogr. F66:143-151(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 6-279
    28. 28.
      "Structural basis for compound C inhibition of the human AMP-activated protein kinase alpha2 subunit kinase domain."
      Handa N. , Takagi T. , Saijo S. , Kishishita S. , Takaya D. , Toyama M. , Terada T. , Shirouzu M. , Suzuki A. , Lee S. , Yamauchi T. , Okada-Iwabu M. , Iwabu M. , Kadowaki T. , Minokoshi Y. , Yokoyama S.
      Acta Crystallogr. D67:480-487(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.08 ANGSTROMS) OF 6-279 OF MUTANT THR-172 IN COMPLEX WITH COMPOUND C;ENZYME REGULATION
    29. 29.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] THR-371 AND GLY-523
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