Protein name:
5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPK subunit alpha-2) ;
Alternative:
2.7.11.31;Hydroxymethylglutaryl-CoA reductase kinase (HMGCR kinase) ;2.7.11.27;Acetyl-CoA carboxylase kinase (ACACA kinase) ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2.
Function:
Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively. Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3. AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160. Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A. Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm. In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription. Acts as a key regulator of cell growth and proliferation by phosphorylating TSC2, RPTOR and ATG1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2. In response to nutrient limitation, promotes autophagy by phosphorylating and activating ULK1. AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it. May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it. Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1.
Subcellular Location:
Cytoplasm
Nucleus
In response to stress, recruited by p53/TP53 to specific promoters.
Protein Attributes:
50:
MAEKQKHDGR | VKIGHYVLGD | TLGVGTFGKV | KIGEHQLTGH | KVAVKILNRQ |
100:
KIRSLDVVGK | IKREIQNLKL | FRHPHIIKLY | QVISTPTDFF | MVMEYVSGGE |
150:
LFDYICKHGR | VEEVEARRLF | QQILSAVDYC | HRHMVVHRDL | KPENVLLDAQ |
200:
MNAKIADFGL | SNMMSDGEFL | RTSCGSPNYA | APEVISGRLY | AGPEVDIWSC |
250:
GVILYALLCG | TLPFDDEHVP | TLFKKIRGGV | FYIPDYLNRS | VATLLMHMLQ |
300:
VDPLKRATIK | DIREHEWFKQ | DLPSYLFPED | PSYDANVIDD | EAVKEVCEKF |
350:
ECTESEVMNS | LYSGDPQDQL | AVAYHLIIDN | RRIMNQASEF | YLASSPPSGS |
400:
FMDDSAMHIP | PGLKPHPERM | PPLIADSPKA | RCPLDALNTT | KPKSLAVKKA |
450:
KWHLGIRSQS | KACDIMAEVY | RAMKQLGFEW | KVVNAYHLRV | RRKNPVTGNY |
500:
VKMSLQLYLV | DSRSYLLDFK | SIDDEVVEQR | SGSSTPQRSC | SAAGLHRARS |
550:
SFDSSTAENH | SLSGSLTGSL | TGSTLSSASP | RLGSHTMDFF | EMCASLITAL |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Pig
Mouse
Rat
ELISA Kit for Mouse AMPK subunit alpha-2
ELISA Kit for Mouse AMPK subunit alpha-2
ELISA Kit for Mouse AMPK subunit alpha-2
ELISA Kit for Mouse AMPK subunit alpha-2
CLIA Kit for Mouse AMPK subunit alpha-2
CLIA Kit for Mouse AMPK subunit alpha-2
CLIA Kit for Mouse AMPK subunit alpha-2
CLIA Kit for Mouse AMPK subunit alpha-2
Polyclonal Antibody for Mouse AMPK subunit alpha-2
Polyclonal Antibody for Mouse AMPK subunit alpha-2
Polyclonal Antibody for Mouse AMPK subunit alpha-2
Polyclonal Antibody for Mouse AMPK subunit alpha-2
Monoclonal Antibody for Mouse AMPK subunit alpha-2
Monoclonal Antibody for Mouse AMPK subunit alpha-2
Monoclonal Antibody for Mouse AMPK subunit alpha-2
Monoclonal Antibody for Mouse AMPK subunit alpha-2
Protein for Mouse AMPK subunit alpha-2
Protein for Mouse AMPK subunit alpha-2
Protein for Mouse AMPK subunit alpha-2
Protein for Mouse AMPK subunit alpha-2
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 15-552
strain :
C57BL/6J .
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Brain cortex .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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tissue :
Liver .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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14.
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Science326:437-440(2009)
[
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[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN PHOSPHORYLATION OF CRY1
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN PHOSPHORYLATION OF CTNNB1
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN PHOSPHORYLATION OF H2B;MUTAGENESIS OF ASP-157
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN PHOSPHORYLATION OF HDAC5;MUTAGENESIS OF LYS-45
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION BY ULK1
19.
"AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice."
Li Y.
,
Xu S.
,
Mihaylova M.M.
,
Zheng B.
,
Hou X.
,
Jiang B.
,
Park O.
,
Luo Z.
,
Lefai E.
,
Shyy J.Y.
,
Gao B.
,
Wierzbicki M.
,
Verbeuren T.J.
,
Shaw R.J.
,
Cohen R.A.
,
Zang M.
Cell Metab.13:376-388(2011)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : FUNCTION IN PHOSPHORYLATION OF SREBF1 AND SREBF2;ENZYME REGULATION
20.
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Cited for : FUNCTION IN PHOSPHORYLATION OF ULK1
21.
"Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy."
Egan D.F.
,
Shackelford D.B.
,
Mihaylova M.M.
,
Gelino S.
,
Kohnz R.A.
,
Mair W.
,
Vasquez D.S.
,
Joshi A.
,
Gwinn D.M.
,
Taylor R.
,
Asara J.M.
,
Fitzpatrick J.
,
Dillin A.
,
Viollet B.
,
Kundu M.
,
Hansen M.
,
Shaw R.J.
Science331:456-461(2011)
[
PubMed ]
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Europe PMC ]
[
Abstract ]
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Cited for : FUNCTION IN PHOSPHORYLATION OF ULK1
22.
"The ancient drug salicylate directly activates AMP-activated protein kinase."
Hawley S.A.
,
Fullerton M.D.
,
Ross F.A.
,
Schertzer J.D.
,
Chevtzoff C.
,
Walker K.J.
,
Peggie M.W.
,
Zibrova D.
,
Green K.A.
,
Mustard K.J.
,
Kemp B.E.
,
Sakamoto K.
,
Steinberg G.R.
,
Hardie D.G.
Science336:918-922(2012)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : ENZYME REGULATION BY SALICYLATE