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Index > Protein center > CHRM3(Gene name) > Human
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  • CHRM3 (Gene name),
  • Muscarinic acetylcholine receptor M3 (Protein name ),  ACM3_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    CHRM3;
    Protein name:
    Muscarinic acetylcholine receptor M3;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Function:
    The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
    Subcellular Location:
    Cell membrane Multi-pass membrane protein Cell junction synapse postsynaptic cell membrane Multi-pass membrane protein Basolateral cell membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    590
    Sequence:
    50:
    MTLHNNSTTS | PLFPNISSSW | IHSPSDAGLP | PGTVTHFGSY | NVSRAAGNFS | 
    100:
    SPDGTTDDPL | GGHTVWQVVF | IAFLTGILAL | VTIIGNILVI | VSFKVNKQLK | 
    150:
    TVNNYFLLSL | ACADLIIGVI | SMNLFTTYII | MNRWALGNLA | CDLWLAIDYV | 
    200:
    ASNASVMNLL | VISFDRYFSI | TRPLTYRAKR | TTKRAGVMIG | LAWVISFVLW | 
    250:
    APAILFWQYF | VGKRTVPPGE | CFIQFLSEPT | ITFGTAIAAF | YMPVTIMTIL | 
    300:
    YWRIYKETEK | RTKELAGLQA | SGTEAETENF | VHPTGSSRSC | SSYELQQQSM | 
    350:
    KRSNRRKYGR | CHFWFTTKSW | KPSSEQMDQD | HSSSDSWNNN | DAAASLENSA | 
    400:
    SSDEEDIGSE | TRAIYSIVLK | LPGHSTILNS | TKLPSSDNLQ | VPEEELGMVD | 
    450:
    LERKADKLQA | QKSVDDGGSF | PKSFSKLPIQ | LESAVDTAKT | SDVNSSVGKS | 
    500:
    TATLPLSFKE | ATLAKRFALK | TRSQITKRKR | MSLVKEKKAA | QTLSAILLAF | 
    550:
    IITWTPYNIM | VLVNTFCDSC | IPKTFWNLGY | WLCYINSTVN | PVCYALCNKT | 
    590:
    FRTTFKMLLL | CQCDKKKRRK | QQYQQRQSVI | FHKRAPEQAL | 
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    MIM:
    String:
    MIM:
    Pfam:
    UniGene:
    SMR:
    KEGG:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Muscarinic acetylcholine receptor M3
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    E1838h
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    ELISA Kit for Human Muscarinic acetylcholine receptor M3
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    E1838m
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    ELISA Kit for Human Muscarinic acetylcholine receptor M3
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    E1838b
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    96T
    ELISA Kit for Human Muscarinic acetylcholine receptor M3
    Cat.:
    E1838c
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    ELISA Kit for Human Muscarinic acetylcholine receptor M3
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    E1838p
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    ELISA Kit for Human Muscarinic acetylcholine receptor M3
    Cat.:
    E1838r
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    Packing:
    96T
    CLIA Kit for Human Muscarinic acetylcholine receptor M3
    Cat.:
    U1838c
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    Packing:
    96T
    CLIA Kit for Human Muscarinic acetylcholine receptor M3
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    U1838p
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Muscarinic acetylcholine receptor M3
    Cat.:
    U1838b
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Muscarinic acetylcholine receptor M3
    Cat.:
    U1838m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Muscarinic acetylcholine receptor M3
    Cat.:
    U1838h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    CLIA Kit for Human Muscarinic acetylcholine receptor M3
    Cat.:
    U1838r
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Muscarinic acetylcholine receptor M3
    Polyclonal Antibody for Human Muscarinic acetylcholine receptor M3
    Polyclonal Antibody for Human Muscarinic acetylcholine receptor M3
    Cat.:
    P1838Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Muscarinic acetylcholine receptor M3
    Cat.:
    P1838Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Muscarinic acetylcholine receptor M3
    Cat.:
    P1838Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Muscarinic acetylcholine receptor M3
    Monoclonal Antibody for Human Muscarinic acetylcholine receptor M3
    Monoclonal Antibody for Human Muscarinic acetylcholine receptor M3
    Monoclonal Antibody for Human Muscarinic acetylcholine receptor M3
    Monoclonal Antibody for Human Muscarinic acetylcholine receptor M3
    Monoclonal Antibody for Human Muscarinic acetylcholine receptor M3
    Monoclonal Antibody for Human Muscarinic acetylcholine receptor M3
    Protein for Human Muscarinic acetylcholine receptor M3
    Protein for Human Muscarinic acetylcholine receptor M3
    Protein for Human Muscarinic acetylcholine receptor M3
    Protein for Human Muscarinic acetylcholine receptor M3
    Protein for Human Muscarinic acetylcholine receptor M3
    Protein for Human Muscarinic acetylcholine receptor M3

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    References
    1. 1.
      "Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors."
      Peralta E.G. , Ashkenazi A. , Winslow J.W. , Smith D.H. , Ramachandran J. , Capon D.J.
      EMBO J.6:3923-3929(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    2. 2.
      "Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes."
      Bonner T.I. , Young A.C. , Brann M.R. , Buckley N.J.
      Neuron1:403-410(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      "Human-specific amino acid changes found in 103 protein-coding genes."
      Kitano T. , Liu Y.-H. , Ueda S. , Saitou N.
      Mol. Biol. Evol.21:936-944(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Puhl H.L. III , Ikeda S.R. , Aronstam R.S.
      Submitted (2002-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    5. 5.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    7. 7.
      "Antisense promoter of human L1 retrotransposon drives transcription of adjacent cellular genes."
      Speek M.
      Mol. Cell. Biol.21:1973-1985(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-384
      tissue: Teratocarcinoma.
    8. 8.
      "Mutation of carboxyl-terminal threonine residues in human M3 muscarinic acetylcholine receptor modulates the extent of sequestration and desensitization."
      Yang J. , Williams J.A. , Yule D.I. , Logsdon C.D.
      Mol. Pharmacol.48:477-485(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN EGBRS
    10. 10.
      "The muscarinic M3 acetylcholine receptor exists as two differently sized complexes at the plasma membrane."
      Patowary S. , Alvarez-Curto E. , Xu T.R. , Holz J.D. , Oliver J.A. , Milligan G. , Raicu V.
      Biochem. J.452:303-312(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT;SUBCELLULAR LOCATION
    11. 11.
      "Identification and structural determination of the M(3) muscarinic acetylcholine receptor basolateral sorting signal."
      Iverson H.A. , Fox D. III , Nadler L.S. , Klevit R.E. , Nathanson N.M.
      J. Biol. Chem.280:24568-24575(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 271-289;MUTAGENESIS OF GLU-276; PHE-280 AND VAL-281;SUBCELLULAR LOCATION
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