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Index > Protein center > AGRP(Gene name) > Human
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  • AGRP (Gene name),
  • Agouti-related protein (Protein name ),  AGRP_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    AGRP(AGRT;ART);
    Protein name:
    Agouti-related protein;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with melanocortin receptors MC3R, MC4R and MC5R.
    Function:
    Plays a role in weight homeostasis. Plays a role in the central control of feeding. Reduces food intake. Inhibits cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Acts primarily on MC3R and MC4R. Has very low activity with MC5R.
    Subcellular Location:
    Secreted Golgi apparatus lumen
    Protein Attributes:
    Sequence length:
    132
    Sequence:
    50:
    MLTAAVLSCA | LLLALPATRG | AQMGLAPMEG | IRRPDQALLP | ELPGLGLRAP | 
    100:
    LKKTTAEQAE | EDLLQEAQAL | AEVLDLQDRE | PRSSRRCVRL | HESCLGQQVP | 
    132:
    CCDPCATCYC | RFFNAFCYCR | KLGTAMNPCS | RT
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    SMR:
    MIM:
    String:
    UniGene:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Agouti-related protein
    Cat.:
    E1302h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Agouti-related protein
    Cat.:
    E1302b
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    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Agouti-related protein
    Cat.:
    E1302m
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Agouti-related protein
    Cat.:
    E1302p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Agouti-related protein
    Cat.:
    U1302m
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Agouti-related protein
    Cat.:
    U1302b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Agouti-related protein
    Cat.:
    U1302h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Agouti-related protein
    Cat.:
    U1302p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Agouti-related protein
    Polyclonal Antibody for Human Agouti-related protein
    Polyclonal Antibody for Human Agouti-related protein
    Cat.:
    P1302Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Agouti-related protein
    Cat.:
    P1302Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Agouti-related protein
    Monoclonal Antibody for Human Agouti-related protein
    Monoclonal Antibody for Human Agouti-related protein
    Monoclonal Antibody for Human Agouti-related protein
    Protein for Human Agouti-related protein
    Protein for Human Agouti-related protein
    Protein for Human Agouti-related protein
    Protein for Human Agouti-related protein

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice."
      Shutter J.R. , Graham M. , Kinsey A.C. , Scully S. , Luethy R. , Stark K.L.
      Genes Dev.11:593-602(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein."
      Ollmann M.M. , Wilson B.D. , Yang Y.K. , Kerns J.A. , Chen Y. , Gantz I. , Barsh G.S.
      Science278:135-138(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Adrenal gland.
    3. 3.
      "The gene structure and minimal promoter of the human agouti related protein."
      Brown A.M. , Mayfield D.K. , Volaufova J. , Argyropoulos G.
      Gene277:231-238(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT THR-67
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    5. 5.
      SeattleSNPs variation discovery resource
      Submitted (2006-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    7. 7.
      "Determination of disulfide structure in agouti-related protein (AGRP) by stepwise reduction and alkylation."
      Bures E.J. , Hui J.O. , Young Y. , Chow D.T. , Katta V. , Rohde M.F. , Zeni L. , Rosenfeld R.D. , Stark K.L. , Haniu M.
      Biochemistry37:12172-12177(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISULFIDE BONDS
    8. 8.
      "Characterization of Agouti-related protein binding to melanocortin receptors."
      Yang Y.K. , Thompson D.A. , Dickinson C.J. , Wilken J. , Barsh G.S. , Kent S.B. , Gantz I.
      Mol. Endocrinol.13:148-155(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH MC3R; MC4R AND MC5R
    9. 9.
      "AgRP(83-132) acts as an inverse agonist on the human-melanocortin-4 receptor."
      Nijenhuis W.A. , Oosterom J. , Adan R.A.
      Mol. Endocrinol.15:164-171(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS INVERSE AGONIST FOR MC3R AND MC4R
    10. 10.
      "The natural inverse agonist agouti-related protein induces arrestin-mediated endocytosis of melanocortin-3 and -4 receptors."
      Breit A. , Wolff K. , Kalwa H. , Jarry H. , Buch T. , Gudermann T.
      J. Biol. Chem.281:37447-37456(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN MC3R AND MC4R ENDOCYTOSIS
    11. 11.
      "NMR structure of a minimized human agouti related protein prepared by total chemical synthesis."
      Bolin K.A. , Anderson D.J. , Trulson J.A. , Thompson D.A. , Wilken J. , Kent S.B.H. , Gantz I. , Millhauser G.L.
      FEBS Lett.451:125-131(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 87-132;FUNCTION;CIRCULAR DICHROISM;DISULFIDE BONDS;MUTAGENESIS OF ARG-111
    12. 12.
      "High-resolution NMR structure of the chemically-synthesized melanocortin receptor binding domain AGRP(87-132) of the agouti-related protein."
      McNulty J.C. , Thompson D.A. , Bolin K.A. , Wilken J. , Barsh G.S. , Millhauser G.L.
      Biochemistry40:15520-15527(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 87-132;DOMAIN;DISULFIDE BONDS
    13. 13.
      "Design, pharmacology, and NMR structure of a minimized cystine knot with agouti-related protein activity."
      Jackson P.J. , McNulty J.C. , Yang Y.K. , Thompson D.A. , Chai B. , Gantz I. , Barsh G.S. , Millhauser G.L.
      Biochemistry41:7565-7572(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 87-120
    14. 14.
      "A polymorphism in the human agouti-related protein is associated with late-onset obesity."
      Argyropoulos G. , Rankinen T. , Neufeld D.R. , Rice T. , Province M.A. , Leon A.S. , Skinner J.S. , Wilmore J.H. , Rao D.C. , Bouchard C.
      J. Clin. Endocrinol. Metab.87:4198-4202(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT THR-67;POSSIBLE ASSOCIATION WITH OBESITY
    15. 15.
      "Functional analysis of the Ala67Thr polymorphism in agouti related protein associated with anorexia nervosa and leanness."
      de Rijke C.E. , Jackson P.J. , Garner K.M. , van Rozen R.J. , Douglas N.R. , Kas M.J. , Millhauser G.L. , Adan R.A.
      Biochem. Pharmacol.70:308-316(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANT THR-67;SUBCELLULAR LOCATION;FUNCTION
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