AGRP ELISA Kit for Human(Homo sapiens) | EIAab.comAGRP ELISA Kit for Human(Homo sapiens)

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Index > Protein center > AGRP(Gene name) > Human

AGRP (Gene name),

Agouti-related protein (Protein name ), AGRP_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

AGRP(AGRT;ART);

Protein name:

Agouti-related protein;

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with melanocortin receptors MC3R, MC4R and MC5R.

Function:

Plays a role in weight homeostasis. Plays a role in the central control of feeding. Reduces food intake. Inhibits cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Acts primarily on MC3R and MC4R. Has very low activity with MC5R.

Subcellular Location:

Secreted Golgi apparatus lumen

Protein Attributes:

Sequence length:

132

Sequence:

50:

100:

132:

CCDPCATCYC | RFFNAFCYCR | KLGTAMNPCS | RT

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF05039

SMR:

O00253

MIM:

601665

String:

O00253

UniGene:

Hs.104633

KEGG:

hsa:181

STRING:

9606.ENSP00000290953

Uniprot:

O00253

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ELISA Kit for Human Agouti-related protein

Cat.:

E1302h

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96T

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ELISA Kit for Human Agouti-related protein

Cat.:

E1302b

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96T

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ELISA Kit for Human Agouti-related protein

Cat.:

E1302m

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96T

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ELISA Kit for Human Agouti-related protein

Cat.:

E1302p

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MSDS:

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Packing:

96T

CLIA Kit for Human Agouti-related protein

Cat.:

U1302m

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MSDS:

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Packing:

96T

CLIA Kit for Human Agouti-related protein

Cat.:

U1302b

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

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CLIA Kit for Human Agouti-related protein

Cat.:

U1302h

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Human Agouti-related protein

Cat.:

U1302p

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Packing:

96T

Polyclonal Antibody for Human Agouti-related protein

Cat.:

P1302Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Agouti-related protein

Cat.:

P1302Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Agouti-related protein

Protein for Human Agouti-related protein

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice."
Shutter J.R. , Graham M. , Kinsey A.C. , Scully S. , Luethy R. , Stark K.L.
Genes Dev.11:593-602(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein."
Ollmann M.M. , Wilson B.D. , Yang Y.K. , Kerns J.A. , Chen Y. , Gantz I. , Barsh G.S.
Science278:135-138(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Adrenal gland.
3.

"The gene structure and minimal promoter of the human agouti related protein."
Brown A.M. , Mayfield D.K. , Volaufova J. , Argyropoulos G.
Gene277:231-238(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT THR-67
4.

"Association between an agouti-related protein gene polymorphism and anorexia nervosa."
Vink T. , Hinney A. , van Elburg A.A. , van Goozen S.H. , Sandkuijl L.A. , Sinke R.J. , Herpertz-Dahlmann B.M. , Hebebrand J. , Remschmidt H. , van Engeland H. , Adan R.A.
Mol. Psychiatry6:325-328(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
5.

SeattleSNPs variation discovery resource
Submitted (2006-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
7.

"Determination of disulfide structure in agouti-related protein (AGRP) by stepwise reduction and alkylation."
Bures E.J. , Hui J.O. , Young Y. , Chow D.T. , Katta V. , Rohde M.F. , Zeni L. , Rosenfeld R.D. , Stark K.L. , Haniu M.
Biochemistry37:12172-12177(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISULFIDE BONDS
8.

"Characterization of Agouti-related protein binding to melanocortin receptors."
Yang Y.K. , Thompson D.A. , Dickinson C.J. , Wilken J. , Barsh G.S. , Kent S.B. , Gantz I.
Mol. Endocrinol.13:148-155(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH MC3R; MC4R AND MC5R
9.

"AgRP(83-132) acts as an inverse agonist on the human-melanocortin-4 receptor."
Nijenhuis W.A. , Oosterom J. , Adan R.A.
Mol. Endocrinol.15:164-171(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS INVERSE AGONIST FOR MC3R AND MC4R
10.

"The natural inverse agonist agouti-related protein induces arrestin-mediated endocytosis of melanocortin-3 and -4 receptors."
Breit A. , Wolff K. , Kalwa H. , Jarry H. , Buch T. , Gudermann T.
J. Biol. Chem.281:37447-37456(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN MC3R AND MC4R ENDOCYTOSIS
11.

"NMR structure of a minimized human agouti related protein prepared by total chemical synthesis."
Bolin K.A. , Anderson D.J. , Trulson J.A. , Thompson D.A. , Wilken J. , Kent S.B.H. , Gantz I. , Millhauser G.L.
FEBS Lett.451:125-131(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 87-132;FUNCTION;CIRCULAR DICHROISM;DISULFIDE BONDS;MUTAGENESIS OF ARG-111
12.

"High-resolution NMR structure of the chemically-synthesized melanocortin receptor binding domain AGRP(87-132) of the agouti-related protein."
McNulty J.C. , Thompson D.A. , Bolin K.A. , Wilken J. , Barsh G.S. , Millhauser G.L.
Biochemistry40:15520-15527(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 87-132;DOMAIN;DISULFIDE BONDS
13.

"Design, pharmacology, and NMR structure of a minimized cystine knot with agouti-related protein activity."
Jackson P.J. , McNulty J.C. , Yang Y.K. , Thompson D.A. , Chai B. , Gantz I. , Barsh G.S. , Millhauser G.L.
Biochemistry41:7565-7572(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 87-120
14.

"A polymorphism in the human agouti-related protein is associated with late-onset obesity."
Argyropoulos G. , Rankinen T. , Neufeld D.R. , Rice T. , Province M.A. , Leon A.S. , Skinner J.S. , Wilmore J.H. , Rao D.C. , Bouchard C.
J. Clin. Endocrinol. Metab.87:4198-4202(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT THR-67;POSSIBLE ASSOCIATION WITH OBESITY
15.

"Functional analysis of the Ala67Thr polymorphism in agouti related protein associated with anorexia nervosa and leanness."
de Rijke C.E. , Jackson P.J. , Garner K.M. , van Rozen R.J. , Douglas N.R. , Kas M.J. , Millhauser G.L. , Adan R.A.
Biochem. Pharmacol.70:308-316(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANT THR-67;SUBCELLULAR LOCATION;FUNCTION

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