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Index > Protein center > AKT1(Gene name) > Human
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  • AKT1 (Gene name),
  • RAC-alpha serine/threonine-protein kinase (Protein name ),  AKT1_HUMAN from NCBI database.
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  • Gene name:
    AKT1(PKB;RAC);
    Protein name:
    RAC-alpha serine/threonine-protein kinase;
    Alternative:
    Protein kinase B alpha(PKB alpha);Protein kinase B(PKB);RAC-PK-alpha;Proto-oncogene c-Akt;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with AGAP2 (isoform 2, PIKE-A), the interaction requires guanine nucleotides and stimulates the kinase activity. Interacts (via the C-terminus) with CCDC88A (via its C-terminus) and THEM4 (via its C-terminus). Interacts with AKTIP. Interacts (via PH domain) with MTCP1, TCL1A AND TCL1B. Interacts with MAP3K5 and TRAF6. Interacts with GRB10; the interaction leads to GRB10 phosphorylation thus promoting YWHAE binding. Interacts with RARA; the interaction phosphorylates RARA and represses its transactivation activity. Interacts with TNK2. Interacts with CLK2 and PPP2R5B. Interacts with STK3/MST2 and STK4/MST1.
    Function:
    AKT1-specific substrates have been recently identified, including palladin (PALLD), which phosphorylation modulates cytoskeletal organization and cell motility; prohibitin (PHB), playing an important role in cell metabolism and proliferation; and CDKN1A, for which phosphorylation at 'Thr-145' induces its release from CDK2 and cytoplasmic relocalization. These recent findings indicate that the AKT1 isoform has a more specific role in cell motility and proliferation. Phosphorylates CLK2 thereby controlling cell survival to ionizing radiation.
    Subcellular Location:
    Cytoplasm Nucleus Cell membrane Nucleus after activation by integrin-linked protein kinase 1 (ILK1). Nuclear translocation is enhanced by interaction with TCL1A. Phosphorylation on Tyr-176 by TNK2 results in its localization to the cell membrane where it is targeted for further phosphorylations on Thr-308 and Ser-473 leading to its activation and the activated form translocates to the nucleus.
    Protein Attributes:
    Sequence length:
    480
    Sequence:
    50:
    MSDVAIVKEG | WLHKRGEYIK | TWRPRYFLLK | NDGTFIGYKE | RPQDVDQREA | 
    100:
    PLNNFSVAQC | QLMKTERPRP | NTFIIRCLQW | TTVIERTFHV | ETPEEREEWT | 
    150:
    TAIQTVADGL | KKQEEEEMDF | RSGSPSDNSG | AEEMEVSLAK | PKHRVTMNEF | 
    200:
    EYLKLLGKGT | FGKVILVKEK | ATGRYYAMKI | LKKEVIVAKD | EVAHTLTENR | 
    250:
    VLQNSRHPFL | TALKYSFQTH | DRLCFVMEYA | NGGELFFHLS | RERVFSEDRA | 
    300:
    RFYGAEIVSA | LDYLHSEKNV | VYRDLKLENL | MLDKDGHIKI | TDFGLCKEGI | 
    350:
    KDGATMKTFC | GTPEYLAPEV | LEDNDYGRAV | DWWGLGVVMY | EMMCGRLPFY | 
    400:
    NQDHEKLFEL | ILMEEIRFPR | TLGPEAKSLL | SGLLKKDPKQ | RLGGGSEDAK | 
    450:
    EIMQHRFFAG | IVWQHVYEKK | LSPPFKPQVT | SETDTRYFDE | EFTAQMITIT | 
    480:
    PPDQDDSMEC | VDSERRPHFP | QFSYSASGTA | 
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    KEGG:
    Pfam:
    String:
    SMR:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human RAC-alpha serine/threonine-protein kinase
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    E0382r
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    ELISA Kit for Human RAC-alpha serine/threonine-protein kinase
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    E0382h
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    ELISA Kit for Human RAC-alpha serine/threonine-protein kinase
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    E0382m
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    ELISA Kit for Human RAC-alpha serine/threonine-protein kinase
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    E0382b
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    96T
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    CLIA Kit for Human RAC-alpha serine/threonine-protein kinase
    Cat.:
    U0382b
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human RAC-alpha serine/threonine-protein kinase
    Cat.:
    U0382m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human RAC-alpha serine/threonine-protein kinase
    Cat.:
    U0382h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human RAC-alpha serine/threonine-protein kinase
    Cat.:
    U0382r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human RAC-alpha serine/threonine-protein kinase
    Cat.:
    P0382Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human RAC-alpha serine/threonine-protein kinase
    Cat.:
    P0382Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human RAC-alpha serine/threonine-protein kinase
    Cat.:
    P0382Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human RAC-alpha serine/threonine-protein kinase
    Monoclonal Antibody for Human RAC-alpha serine/threonine-protein kinase
    Monoclonal Antibody for Human RAC-alpha serine/threonine-protein kinase
    Monoclonal Antibody for Human RAC-alpha serine/threonine-protein kinase
    Monoclonal Antibody for Human RAC-alpha serine/threonine-protein kinase
    Protein for Human RAC-alpha serine/threonine-protein kinase
    Protein for Human RAC-alpha serine/threonine-protein kinase
    Protein for Human RAC-alpha serine/threonine-protein kinase
    Protein for Human RAC-alpha serine/threonine-protein kinase

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily."
      Jones P.F. , Jakubowicz T. , Pitossi F.J. , Maurer F. , Hemmings B.A.
      Proc. Natl. Acad. Sci. U.S.A.88:4171-4175(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);CATALYTIC ACTIVITY
    2. 2.
      "Isolation and characterization of the human AKT1 gene, identification of 13 single nucleotide polymorphisms (SNPs), and their lack of association with Type II diabetes."
      Matsubara A. , Wasson J.C. , Donelan S.S. , Welling C.M. , Glaser B. , Permutt M.A.
      Diabetologia44:910-913(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Adrenal gland.
    4. 4.
      "Human protein factory for converting the transcriptome into an in vitro-expressed proteome."
      Goshima N. , Kawamura Y. , Fukumoto A. , Miura A. , Honma R. , Satoh R. , Wakamatsu A. , Yamamoto J. , Kimura K. , Nishikawa T. , Andoh T. , Iida Y. , Ishikawa K. , Ito E. , Kagawa N. , Kaminaga C. , Kanehori K. , Kawakami B. , more...
      Nat. Methods5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    5. 5.
      "The DNA sequence and analysis of human chromosome 14."
      Heilig R. , Eckenberg R. , Petit J.-L. , Fonknechten N. , Da Silva C. , Cattolico L. , Levy M. , Barbe V. , De Berardinis V. , Ureta-Vidal A. , Pelletier E. , Vico V. , Anthouard V. , Rowen L. , Madan A. , Qin S. , Sun H. , Du H. , more...
      Nature421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Muscle.
      tissue: Ovary.
    7. 7.
      "Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families."
      Coffer P.J. , Woodgett J.R.
      Eur. J. Biochem.201:475-481(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 63-480 (ISOFORM 1);FUNCTION;CATALYTIC ACTIVITY;TISSUE SPECIFICITY
      tissue: Foreskin.
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM;SEQUENCE REVISION
    9. 9.
      "CREB is a regulatory target for the protein kinase Akt/PKB."
      Du K. , Montminy M.
      J. Biol. Chem.273:32377-32379(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF CREB1
    10. 10.
      "Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase."
      Delcommenne M. , Tan C. , Gray V. , Rue L. , Woodgett J.R. , Dedhar S.
      Proc. Natl. Acad. Sci. U.S.A.95:11211-11216(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION;PHOSPHORYLATION AT SER-473
    11. 11.
      "Mechanism of activation of protein kinase B by insulin and IGF-1."
      Alessi D.R. , Andjelkovic M. , Caudwell F.B. , Cron P. , Morrice N. , Cohen P. , Hemmings B.A.
      EMBO J.15:6541-6551(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF THR-308 AND SER-473;PHOSPHORYLATION AT THR-308 AND SER-473
    12. 12.
      "Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha."
      Walker K.S. , Deak M. , Paterson A. , Hudson K. , Cohen P. , Alessi D.R.
      Biochem. J.331:299-308(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ENZYME REGULATION;PHOSPHORYLATION AT THR-308 BY PDPK1
    13. 13.
      "Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B."
      Rena G. , Guo S. , Cichy S.C. , Unterman T.G. , Cohen P.
      J. Biol. Chem.274:17179-17183(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF FOXO1
    14. 14.
      "Phosphorylation and regulation of Raf by Akt (protein kinase B)."
      Zimmermann S. , Moelling K.
      Science286:1741-1744(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF RAF1;INTERACTION WITH RAF1
    15. 15.
      "Inhibition of Akt and its anti-apoptotic activities by tumor necrosis factor-induced protein kinase C-related kinase 2 (PRK2) cleavage."
      Koh H. , Lee K.H. , Kim D. , Kim S. , Kim J.W. , Chung J.
      J. Biol. Chem.275:34451-34458(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF BAD;INTERACTION WITH BAD AND PKN2
    16. 16.
      "The protooncogene TCL1 is an Akt kinase coactivator."
      Laine J. , Kuenstle G. , Obata T. , Sha M. , Noguchi M.
      Mol. Cell6:395-407(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MTCP1; TCL1A AND TCL1B
    17. 17.
      "Tcl1 enhances Akt kinase activity and mediates its nuclear translocation."
      Pekarsky Y. , Koval A. , Hallas C. , Bichi R. , Tresini M. , Malstrom S. , Russo G. , Tsichlis P. , Croce C.M.
      Proc. Natl. Acad. Sci. U.S.A.97:3028-3033(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TCL1A
    18. 18.
      "Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1."
      Kim A.H. , Khursigara G. , Sun X. , Franke T.F. , Chao M.V.
      Mol. Cell. Biol.21:893-901(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF MAP3K5;INTERACTION WITH MAP3K5
    19. 19.
      "Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane."
      Maira S.-M. , Galetic I. , Brazil D.P. , Kaech S. , Ingley E. , Thelen M. , Hemmings B.A.
      Science294:374-380(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH THEM4;SUBCELLULAR LOCATION
    20. 20.
      "A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain."
      Kane S. , Sano H. , Liu S.C.H. , Asara J.M. , Lane W.S. , Garner C.C. , Lienhard G.E.
      J. Biol. Chem.277:22115-22118(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF TBC1D4
    21. 21.
      "Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization."
      Fujita N. , Sato S. , Katayama K. , Tsuruo T.
      J. Biol. Chem.277:28706-28713(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CDKN1B;FUNCTION
    22. 22.
      "Direct identification of tyrosine 474 as a regulatory phosphorylation site for the Akt protein kinase."
      Conus N.M. , Hannan K.M. , Cristiano B.E. , Hemmings B.A. , Pearson R.B.
      J. Biol. Chem.277:38021-38028(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-474;MUTAGENESIS OF TYR-474
    23. 23.
      "Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway."
      Manning B.D. , Tee A.R. , Logsdon M.N. , Blenis J. , Cantley L.C.
      Mol. Cell10:151-162(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF TSC2
    24. 24.
      "Identification of Akt association and oligomerization domains of the Akt kinase coactivator TCL1."
      Kuenstle G. , Laine J. , Pierron G. , Kagami S. , Nakajima H. , Hoh F. , Roumestand C. , Stern M.H. , Noguchi M.
      Mol. Cell. Biol.22:1513-1525(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TCL1A
    25. 25.
      "PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization."
      Shin I. , Yakes F.M. , Rojo F. , Shin N.-Y. , Bakin A.V. , Baselga J. , Arteaga C.L.
      Nat. Med.8:1145-1152(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CDKN1B;FUNCTION;MUTAGENESIS OF THR-308 AND SER-473
    26. 26.
      "Identification of Tyr900 in the kinase domain of c-Kit as a Src-dependent phosphorylation site mediating interaction with c-Crk."
      Lennartsson J. , Wernstedt C. , Engstrom U. , Hellman U. , Ronnstrand L.
      Exp. Cell Res.288:110-118(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PARTICIPATION IN KIT SIGNALING
    27. 27.
      "PIKE (phosphatidylinositol 3-kinase enhancer)-A GTPase stimulates Akt activity and mediates cellular invasion."
      Ahn J.-Y. , Rong R. , Kroll T.G. , Van Meir E.G. , Snyder S.H. , Ye K.
      J. Biol. Chem.279:16441-16451(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AGAP2;PHOSPHORYLATION AT SER-473
    28. 28.
      "LGI1, a putative tumor metastasis suppressor gene, controls in vitro invasiveness and expression of matrix metalloproteinases in glioma cells through the ERK1/2 pathway."
      Kunapuli P. , Kasyapa C.S. , Hawthorn L. , Cowell J.K.
      J. Biol. Chem.279:23151-23157(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-473
    29. 29.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    30. 30.
      "Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt."
      Remy I. , Michnick S.W.
      Mol. Cell. Biol.24:1493-1504(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AKTIP
    31. 31.
      "PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt."
      Ahn J.-Y. , Hu Y. , Kroll T.G. , Allard P. , Ye K.
      Proc. Natl. Acad. Sci. U.S.A.101:6993-6998(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AGAP2
    32. 32.
      "Constitutive activation of Akt by Flt3 internal tandem duplications is necessary for increased survival, proliferation, and myeloid transformation."
      Brandts C.H. , Sargin B. , Rode M. , Biermann C. , Lindtner B. , Schwable J. , Buerger H. , Muller-Tidow C. , Choudhary C. , McMahon M. , Berdel W.E. , Serve H.
      Cancer Res.65:9643-9650(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-473 IN RESPONSE TO FLT3 SIGNALING
    33. 33.
      "Akt/PKB regulates actin organization and cell motility via Girdin/APE."
      Enomoto A. , Murakami H. , Asai N. , Morone N. , Watanabe T. , Kawai K. , Murakumo Y. , Usukura J. , Kaibuchi K. , Takahashi M.
      Dev. Cell9:389-402(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;INTERACTION WITH CCDC88A
    34. 34.
      "Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex."
      Sarbassov D.D. , Guertin D.A. , Ali S.M. , Sabatini D.M.
      Science307:1098-1101(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-308;PHOSPHORYLATION AT SER-473 BY MTOR
    35. 35.
      "Activation of Akt independent of PTEN and CTMP tumor-suppressor gene mutations in epilepsy-associated Taylor-type focal cortical dysplasias."
      Schick V. , Majores M. , Engels G. , Spitoni S. , Koch A. , Elger C.E. , Simon M. , Knobbe C. , Bluemcke I. , Becker A.J.
      Acta Neuropathol.112:715-725(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-473
    36. 36.
      "Akt phosphorylates and suppresses the transactivation of retinoic acid receptor alpha."
      Srinivas H. , Xia D. , Moore N.L. , Uray I.P. , Kim H. , Ma L. , Weigel N.L. , Brown P.H. , Kurie J.M.
      Biochem. J.395:653-662(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH RARA
    37. 37.
      "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
      Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-129;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    38. 38.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: BIOPHYSICOCHEMICAL PROPERTIES
    39. 39.
      "Only Akt1 is required for proliferation, while Akt2 promotes cell cycle exit through p21 binding."
      Heron-Milhavet L. , Franckhauser C. , Rana V. , Berthenet C. , Fisher D. , Hemmings B.A. , Fernandez A. , Lamb N.J.
      Mol. Cell. Biol.26:8267-8280(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF CDKN1A
    40. 40.
      "The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1."
      Cinar B. , Fang P.K. , Lutchman M. , Di Vizio D. , Adam R.M. , Pavlova N. , Rubin M.A. , Yelick P.C. , Freeman M.R.
      EMBO J.26:4523-4534(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH STK4/MST1;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    41. 41.
      "Akt phosphorylates MstI and prevents its proteolytic activation, blocking FOXO3 phosphorylation and nuclear translocation."
      Jang S.W. , Yang S.J. , Srinivasan S. , Ye K.
      J. Biol. Chem.282:30836-30844(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH STK4/MST1
    42. 42.
      "Characterization of Akt overexpression in MiaPaCa-2 cells: prohibitin is an Akt substrate both in vitro and in cells."
      Han E.K. , Mcgonigal T. , Butler C. , Giranda V.L. , Luo Y.
      Anticancer Res.28:957-963(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF PROHIBITIN
    43. 43.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-124; SER-126 AND SER-129;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    44. 44.
      "The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt."
      Suizu F. , Hiramuki Y. , Okumura F. , Matsuda M. , Okumura A.J. , Hirata N. , Narita M. , Kohno T. , Yokota J. , Bohgaki M. , Obuse C. , Hatakeyama S. , Obata T. , Noguchi M.
      Dev. Cell17:800-810(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION BY TTC3
    45. 45.
      "Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cell cycle and cell death in neurons."
      Jang S.W. , Liu X. , Fu H. , Rees H. , Yepes M. , Levey A. , Ye K.
      J. Biol. Chem.284:24512-24525(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF SRPK2;INTERACTION WITH SRPK2
    46. 46.
      "The Rho-family GEF Asef2 activates Rac to modulate adhesion and actin dynamics and thereby regulate cell migration."
      Bristow J.M. , Sellers M.H. , Majumdar D. , Anderson B. , Hu L. , Webb D.J.
      J. Cell Sci.122:4535-4546(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    47. 47.
      "The E3 ligase TRAF6 regulates Akt ubiquitination and activation."
      Yang W.-L. , Wang J. , Chan C.-H. , Lee S.-W. , Campos A.D. , Lamothe B. , Hur L. , Grabiner B.C. , Lin X. , Darnay B.G. , Lin H.-K.
      Science325:1134-1138(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION;INTERACTION WITH TRAF6;MUTAGENESIS OF LYS-8 AND LYS-14;CHARACTERIZATION OF VARIANT BREAST CANCER LYS-17
    48. 48.
      "Proapoptotic kinase MST2 coordinates signaling crosstalk between RASSF1A, Raf-1, and Akt."
      Romano D. , Matallanas D. , Weitsman G. , Preisinger C. , Ng T. , Kolch W.
      Cancer Res.70:1195-1203(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH STK3/MST2
    49. 49.
      "Phosphoinositide 3-kinase/Akt inhibits MST1-mediated pro-apoptotic signaling through phosphorylation of threonine 120."
      Yuan Z. , Kim D. , Shu S. , Wu J. , Guo J. , Xiao L. , Kaneko S. , Coppola D. , Cheng J.Q.
      J. Biol. Chem.285:3815-3824(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    50. 50.
      "Phosphorylation of CLK2 at serine 34 and threonine 127 by AKT controls cell survival after ionizing radiation."
      Nam S.Y. , Seo H.H. , Park H.S. , An S. , Kim J.Y. , Yang K.H. , Kim C.S. , Jeong M. , Jin Y.W.
      J. Biol. Chem.285:31157-31163(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CLK2
    51. 51.
      "The actin-bundling protein palladin is an Akt1-specific substrate that regulates breast cancer cell migration."
      Chin Y.R. , Toker A.
      Mol. Cell38:333-344(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF PALLD
    52. 52.
      "Regulation of proapoptotic mammalian ste20-like kinase MST2 by the IGF1-Akt pathway."
      Kim D. , Shu S. , Coppola M.D. , Kaneko S. , Yuan Z.Q. , Cheng J.Q.
      PLoS ONE5:E9616-E9616(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH STK3/MST2
    53. 53.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;PHOSPHORYLATION AT TYR-176; THR-308 AND SER-473;MUTAGENESIS OF TYR-176;INTERACTION WITH TNK2;TISSUE SPECIFICITY
    54. 54.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    55. 55.
      "Ret finger protein 2 enhances ionizing radiation-induced apoptosis via degradation of AKT and MDM2."
      Joo H.M. , Kim J.Y. , Jeong J.B. , Seong K.M. , Nam S.Y. , Yang K.H. , Kim C.S. , Kim H.S. , Jeong M. , An S. , Jin Y.W.
      Eur. J. Cell Biol.90:420-431(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TRIM13;UBIQUITINATION
    56. 56.
      "Clk2 and B56-beta mediate insulin-regulated assembly of the PP2A phosphatase holoenzyme complex on Akt."
      Rodgers J.T. , Vogel R.O. , Puigserver P.
      Mol. Cell41:471-479(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PPP2R5B;DEPHOSPHORYLATION
    57. 57.
      "Signal transduction via the stem cell factor receptor/c-Kit."
      Ronnstrand L.
      Cell. Mol. Life Sci.61:2535-2548(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON ROLE IN KIT SIGNALING
    58. 58.
      "The protein kinase B/Akt signalling pathway in human malignancy."
      Nicholson K.M. , Anderson N.G.
      Cell. Signal.14:381-395(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
    59. 59.
      "A novel human dynactin-associated protein, dynAP, promotes activation of Akt, and ergosterol-related compounds induce dynAP-dependent apoptosis of human cancer cells."
      Kunoh T. , Noda T. , Koseki K. , Sekigawa M. , Takagi M. , Shin-ya K. , Goshima N. , Iemura S. , Natsume T. , Wada S. , Mukai Y. , Ohta S. , Sasaki R. , Mizukami T.
      Mol. Cancer Ther.9:2934-2942(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-473
    60. 60.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
    61. 61.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
    62. 62.
      "IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation."
      Xie X. , Zhang D. , Zhao B. , Lu M.K. , You M. , Condorelli G. , Wang C.Y. , Guan K.L.
      Proc. Natl. Acad. Sci. U.S.A.108:6474-6479(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-308 AND SER-473
    63. 63.
      "The deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophy."
      Sundaresan N.R. , Pillai V.B. , Wolfgeher D. , Samant S. , Vasudevan P. , Parekh V. , Raghuraman H. , Cunningham J.M. , Gupta M. , Gupta M.P.
      Sci. Signal.4:RA46-RA46(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SIRT1;ACETYLATION AT LYS-14 AND LYS-20;DEACETYLATION AT LYS-14 AND LYS-20;MUTAGENESIS OF LYS-14; GLU-17 AND LYS-20
    64. 64.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION AT LYS-284
    65. 65.
      "Extensive crosstalk between O-GlcNAcylation and phosphorylation regulates Akt signaling."
      Wang S. , Huang X. , Sun D. , Xin X. , Pan Q. , Peng S. , Liang Z. , Luo C. , Yang Y. , Jiang H. , Huang M. , Chai W. , Ding J. , Geng M.
      PLoS ONE7:E37427-E37427(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT SER-126; SER-129; THR-305 AND THR-312;SUBCELLULAR LOCATION;INTERACTION WITH PDPK1;MUTAGENESIS OF THR-305 AND THR-312
    66. 66.
      "CSTP1, a novel protein phosphatase, blocks cell cycle, promotes cell apoptosis, and suppresses tumor growth of bladder cancer by directly dephosphorylating Akt at Ser473 site."
      Zhuo D.X. , Zhang X.W. , Jin B. , Zhang Z. , Xie B.S. , Wu C.L. , Gong K. , Mao Z.B.
      PLoS ONE8:E65679-E65679(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-473;DEPHOSPHORYLATION BY CPPED1
    67. 67.
      "MOZ increases p53 acetylation and premature senescence through its complex formation with PML."
      Rokudai S. , Laptenko O. , Arnal S.M. , Taya Y. , Kitabayashi I. , Prives C.
      Proc. Natl. Acad. Sci. U.S.A.110:3895-3900(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    68. 68.
      "High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)-trisphosphate."
      Thomas C.C. , Deak M. , Alessi D.R. , van Aalten D.M.
      Curr. Biol.12:1256-1262(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS) OF 1-123;INTERACTION WITH PTDINS(3,4,5)P3 AND PTDINS(3,4)P2;MUTAGENESIS OF LYS-14; ARG-25 AND ARG-86
    69. 69.
      "Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change."
      Milburn C.C. , Deak M. , Kelly S.M. , Price N.C. , Alessi D.R. , Van Aalten D.M.
      Biochem. J.375:531-538(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (0.98 ANGSTROMS) OF 1-121;INTERACTION WITH PTDINS(1,3,4,5)P4
    70. 70.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 144-480;PHOSPHORYLATION AT THR-308;ENZYME REGULATION
    71. 71.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 144-480;ENZYME REGULATION
    72. 72.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.01 ANGSTROMS) OF 144-480;PHOSPHORYLATION AT THR-308;ENZYME REGULATION
    73. 73.
      "Crystal structure of human AKT1 with an allosteric inhibitor reveals a new mode of kinase inhibition."
      Wu W.I. , Voegtli W.C. , Sturgis H.L. , Dizon F.P. , Vigers G.P. , Brandhuber B.J.
      PLoS ONE5:E12913-E12913(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 2-443;DISULFIDE BOND
    74. 74.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 144-480;ENZYME REGULATION
    75. 75.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT BREAST CANCER LYS-17;CHARACTERIZATION OF VARIANT BREAST CANCER LYS-17
    76. 76.
      "Molecular mechanism of an oncogenic mutation that alters membrane targeting: Glu17Lys modifies the PIP lipid specificity of the AKT1 PH domain."
      Landgraf K.E. , Pilling C. , Falke J.J.
      Biochemistry47:12260-12269(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANT PROTEUSS LYS-17
    77. 78.
      "Germline PIK3CA and AKT1 mutations in Cowden and Cowden-like syndromes."
      Orloff M.S. , He X. , Peterson C. , Chen F. , Chen J.L. , Mester J.L. , Eng C.
      Am. J. Hum. Genet.92:76-80(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CWD6 CYS-25 AND PRO-435
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