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Index > Protein center > BMP10(Gene name) > Human
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  • BMP10 (Gene name),
  • Bone morphogenetic protein 10 (Protein name ),  BMP10_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    BMP10;
    Protein name:
    Bone morphogenetic protein 10(BMP-10);
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer; disulfide-linked.
    Function:
    Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    424
    Sequence:
    50:
    MGSLVLTLCA | LFCLAAYLVS | GSPIMNLEQS | PLEEDMSLFG | DVFSEQDGVD | 
    100:
    FNTLLQSMKD | EFLKTLNLSD | IPTQDSAKVD | PPEYMLELYN | KFATDRTSMP | 
    150:
    SANIIRSFKN | EDLFSQPVSF | NGLRKYPLLF | NVSIPHHEEV | IMAELRLYTL | 
    200:
    VQRDRMIYDG | VDRKITIFEV | LESKGDNEGE | RNMLVLVSGE | IYGTNSEWET | 
    250:
    FDVTDAIRRW | QKSGSSTHQL | EVHIESKHDE | AEDASSGRLE | IDTSAQNKHN | 
    300:
    PLLIVFSDDQ | SSDKERKEEL | NEMISHEQLP | ELDNLGLDSF | SSGPGEEALL | 
    350:
    QMRSNIIYDS | TARIRRNAKG | NYCKRTPLYI | DFKEIGWDSW | IIAPPGYEAY | 
    400:
    ECRGVCNYPL | AEHLTPTKHA | IIQALVHLKN | SQKASKACCV | PTKLEPISIL | 
    424:
    YLDKGVVTYK | FKYEGMAVSE | CGCR
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    MIM:
    SMR:
    UniGene:
    String:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human BMP-10
    Cat.:
    E1115h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human BMP-10
    Cat.:
    E1115r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human BMP-10
    Cat.:
    E1115m
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human BMP-10
    Cat.:
    U1115m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human BMP-10
    Cat.:
    U1115r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human BMP-10
    Cat.:
    U1115h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human BMP-10
    Cat.:
    P1115Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human BMP-10
    Cat.:
    P1115Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human BMP-10
    Cat.:
    P1115Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human BMP-10
    Monoclonal Antibody for Human BMP-10
    Monoclonal Antibody for Human BMP-10
    Protein for Human BMP-10
    Protein for Human BMP-10
    Protein for Human BMP-10

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    Precision
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    Linearity
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    References
    1. 1.
      "Homo sapiens bone morphogenetic protein 10 (BMP-10) mRNA."
      Celeste A.J.
      Submitted (1998-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Cerebellum.
    4. 4.
      "Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses."
      Mazerbourg S. , Sangkuhl K. , Luo C.-W. , Sudo S. , Klein C. , Hsueh A.J.W.
      J. Biol. Chem.280:32122-32132(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    5. 5.
      "Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells."
      David L. , Mallet C. , Mazerbourg S. , Feige J.-J. , Bailly S.
      Blood109:1953-1961(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    6. 6.
      "Bone morphogenetic protein-10 (BMP-10) inhibits aggressiveness of breast cancer cells and correlates with poor prognosis in breast cancer."
      Ye L. , Bokobza S. , Li J. , Moazzam M. , Chen J. , Mansel R.E. , Jiang W.G.
      Cancer Sci.101:2137-2144(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;INDUCTION
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