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Index > Protein center > BMP1(Gene name) > Human
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  • BMP1 (Gene name),
  • Bone morphogenetic protein 1 (Protein name ),  BMP1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    BMP1(PCOLC);
    Protein name:
    Bone morphogenetic protein 1(BMP-1);
    Alternative:
    Procollagen C-proteinase(PCP);Mammalian tolloid protein(mTld);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Cleaves the C-terminal propeptides of procollagen I, II and III. Induces cartilage and bone formation. May participate in dorsoventral patterning during early development by cleaving chordin (CHRD).
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    986
    Sequence:
    50:
    MPGVARLPLL | LGLLLLPRPG | RPLDLADYTY | DLAEEDDSEP | LNYKDPCKAA | 
    100:
    AFLGDIALDE | EDLRAFQVQQ | AVDLRRHTAR | KSSIKAAVPG | NTSTPSCQST | 
    150:
    NGQPQRGACG | RWRGRSRSRR | AATSRPERVW | PDGVIPFVIG | GNFTGSQRAV | 
    200:
    FRQAMRHWEK | HTCVTFLERT | DEDSYIVFTY | RPCGCCSYVG | RRGGGPQAIS | 
    250:
    IGKNCDKFGI | VVHELGHVVG | FWHEHTRPDR | DRHVSIVREN | IQPGQEYNFL | 
    300:
    KMEPQEVESL | GETYDFDSIM | HYARNTFSRG | IFLDTIVPKY | EVNGVKPPIG | 
    350:
    QRTRLSKGDI | AQARKLYKCP | ACGETLQDST | GNFSSPEYPN | GYSAHMHCVW | 
    400:
    RISVTPGEKI | ILNFTSLDLY | RSRLCWYDYV | EVRDGFWRKA | PLRGRFCGSK | 
    450:
    LPEPIVSTDS | RLWVEFRSSS | NWVGKGFFAV | YEAICGGDVK | KDYGHIQSPN | 
    500:
    YPDDYRPSKV | CIWRIQVSEG | FHVGLTFQSF | EIERHDSCAY | DYLEVRDGHS | 
    550:
    ESSTLIGRYC | GYEKPDDIKS | TSSRLWLKFV | SDGSINKAGF | AVNFFKEVDE | 
    600:
    CSRPNRGGCE | QRCLNTLGSY | KCSCDPGYEL | APDKRRCEAA | CGGFLTKLNG | 
    650:
    SITSPGWPKE | YPPNKNCIWQ | LVAPTQYRIS | LQFDFFETEG | NDVCKYDFVE | 
    700:
    VRSGLTADSK | LHGKFCGSEK | PEVITSQYNN | MRVEFKSDNT | VSKKGFKAHF | 
    750:
    FSDKDECSKD | NGGCQQDCVN | TFGSYECQCR | SGFVLHDNKH | DCKEAGCDHK | 
    800:
    VTSTSGTITS | PNWPDKYPSK | KECTWAISST | PGHRVKLTFM | EMDIESQPEC | 
    850:
    AYDHLEVFDG | RDAKAPVLGR | FCGSKKPEPV | LATGSRMFLR | FYSDNSVQRK | 
    900:
    GFQASHATEC | GGQVRADVKT | KDLYSHAQFG | DNNYPGGVDC | EWVIVAEEGY | 
    950:
    GVELVFQTFE | VEEETDCGYD | YMELFDGYDS | TAPRLGRYCG | SGPPEEVYSA | 
    986:
    GDSVLVKFHS | DDTITKKGFH | LRYTSTKFQD | TLHSRK
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    MIM:
    Pfam:
    SMR:
    KEGG:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human BMP-1
    Cat.:
    E1316h
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    ELISA Kit for Human BMP-1
    Cat.:
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    Packing:
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    CLIA Kit for Human BMP-1
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    MSDS:
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    Packing:
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    Range:
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    CLIA Kit for Human BMP-1
    Cat.:
    U1316m
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    Packing:
    96T
    Polyclonal Antibody for Human BMP-1
    Cat.:
    P1316Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human BMP-1
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    P1316Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human BMP-1
    Monoclonal Antibody for Human BMP-1
    Protein for Human BMP-1
    Protein for Human BMP-1

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    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "The C-proteinase that processes procollagens to fibrillar collagens is identical to the protein previously identified as bone morphogenic protein-1."
      Li S.W. , Sieron A.L. , Fertala A. , Hojima Y. , Arnold W.V. , Prockop D.J.
      Proc. Natl. Acad. Sci. U.S.A.93:5127-5130(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BMP1-3)
      tissue: Skin.
    2. 2.
      "Novel regulators of bone formation: molecular clones and activities."
      Wozney J.M. , Rosen V. , Celeste A.J. , Mitsock L.M. , Whitters M.J. , Kriz R.W. , Hewick R.M. , Wang E.A.
      Science242:1528-1534(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BMP1-1)
    3. 3.
      "Three alternatively spliced variants of the gene coding for the human bone morphogenetic protein-1."
      Janitz M. , Heiser V. , Boettcher U. , Landt O. , Lauster R.
      J. Mol. Med.76:141-146(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS BMP1-4; BMP1-5 AND BMP1-6)
      tissue: Placenta.
    4. 4.
      "Bone morphogenetic protein-1 and a mammalian tolloid homologue (mTld) are encoded by alternatively spliced transcripts which are differentially expressed in some tissues."
      Takahara K. , Lyons G.E. , Greenspan D.S.
      J. Biol. Chem.269:32572-32578(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS BMP1-3 AND BMP1-7)
      tissue: Placenta.
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BMP1-5)
      tissue: Placenta.
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BMP1-3)
      tissue: Brain.
    8. 8.
      "Identification of amino acid residues in bone morphogenetic protein-1 important for procollagen C-proteinase activity."
      Garrigue-Antar L. , Barker C. , Kadler K.E.
      J. Biol. Chem.276:26237-26242(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISULFIDE BOND AT 183-CYS--CYS-186
    9. 9.
      "Paired basic/Furin-like proprotein convertase cleavage of Pro-BMP-1 in the trans-Golgi network."
      Leighton M. , Kadler K.E.
      J. Biol. Chem.278:18478-18484(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;PROTEOLYTIC CLEAVAGE;MUTAGENESIS OF 119-ARG--ARG-120
    10. 10.
      "An unappreciated role for RNA surveillance."
      Hillman R.T. , Green R.E. , Brenner S.E.
      Genome Biol.5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S)
    11. 11.
      "Structural basis for the substrate specificity of bone morphogenetic protein 1/tolloid-like metalloproteases."
      Mac Sweeney A. , Gil-Parrado S. , Vinzenz D. , Bernardi A. , Hein A. , Bodendorf U. , Erbel P. , Logel C. , Gerhartz B.
      J. Mol. Biol.384:228-239(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.25 ANGSTROMS) OF 121-321;ZINC-BINDING SITES;COFACTOR;ACTIVE SITE;DISULFIDE BONDS
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] HIS-45
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT OI13 ARG-12;CHARACTERIZATION OF VARIANT OI13 ARG-12
    14. 14.
      "Identification of a mutation causing deficient BMP1/mTLD proteolytic activity in autosomal recessive osteogenesis imperfecta."
      Martinez-Glez V. , Valencia M. , Caparros-Martin J.A. , Aglan M. , Temtamy S. , Tenorio J. , Pulido V. , Lindert U. , Rohrbach M. , Eyre D. , Giunta C. , Lapunzina P. , Ruiz-Perez V.L.
      Hum. Mutat.33:343-350(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT OI13 LEU-249;CHARACTERIZATION OF VARIANT OI13 LEU-249
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