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Index > Protein center > CTSK(Gene name) > Human
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  • CTSK (Gene name),
  • Cathepsin K (Protein name ),  CATK_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    CTSK(CTSO;CTSO2);
    Protein name:
    Cathepsin K;
    Alternative:
    Cathepsin O2;Cathepsin O;Cathepsin X;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.
    Subcellular Location:
    Lysosome
    Protein Attributes:
    Sequence length:
    329
    Sequence:
    50:
    MWGLKVLLLP | VVSFALYPEE | ILDTHWELWK | KTHRKQYNNK | VDEISRRLIW | 
    100:
    EKNLKYISIH | NLEASLGVHT | YELAMNHLGD | MTSEEVVQKM | TGLKVPLSHS | 
    150:
    RSNDTLYIPE | WEGRAPDSVD | YRKKGYVTPV | KNQGQCGSCW | AFSSVGALEG | 
    200:
    QLKKKTGKLL | NLSPQNLVDC | VSENDGCGGG | YMTNAFQYVQ | KNRGIDSEDA | 
    250:
    YPYVGQEESC | MYNPTGKAAK | CRGYREIPEG | NEKALKRAVA | RVGPVSVAID | 
    300:
    ASLTSFQFYS | KGVYYDESCN | SDNLNHAVLA | VGYGIQKGNK | HWIIKNSWGE | 
    329:
    NWGNKGYILM | ARNKNNACGI | ANLASFPKM
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    KEGG:
    Pfam:
    UniGene:
    String:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Cathepsin K
    Cat.:
    E0267h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human Cathepsin K
    Cat.:
    E0267r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Human Cathepsin K
    Cat.:
    E0267m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Human Cathepsin K
    Cat.:
    E0267d
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Human Cathepsin K
    Cat.:
    E0267p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Cathepsin K
    Cat.:
    E0267c
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Cathepsin K
    Cat.:
    E0267b
    Price:
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Cathepsin K
    MSDS:
    Please sign in first.
    CLIA Kit for Human Cathepsin K
    Cat.:
    U0267p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Cathepsin K
    Cat.:
    U0267m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Cathepsin K
    MSDS:
    Please sign in first.
    CLIA Kit for Human Cathepsin K
    Cat.:
    U0267r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Cathepsin K
    Cat.:
    U0267h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Cathepsin K
    Cat.:
    U0267d
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Cathepsin K
    Cat.:
    U0267b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Cathepsin K
    Cat.:
    U0267c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Cathepsin K
    Polyclonal Antibody for Human Cathepsin K
    Polyclonal Antibody for Human Cathepsin K
    Cat.:
    P0267Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Cathepsin K
    Polyclonal Antibody for Human Cathepsin K
    Polyclonal Antibody for Human Cathepsin K
    Cat.:
    P0267Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Cathepsin K
    Polyclonal Antibody for Human Cathepsin K
    Cat.:
    P0267Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Cathepsin K
    Monoclonal Antibody for Human Cathepsin K
    Monoclonal Antibody for Human Cathepsin K
    Monoclonal Antibody for Human Cathepsin K
    Monoclonal Antibody for Human Cathepsin K
    Monoclonal Antibody for Human Cathepsin K
    Monoclonal Antibody for Human Cathepsin K
    Monoclonal Antibody for Human Cathepsin K
    Protein for Human Cathepsin K
    Protein for Human Cathepsin K
    Protein for Human Cathepsin K
    Protein for Human Cathepsin K
    Protein for Human Cathepsin K
    Protein for Human Cathepsin K
    Protein for Human Cathepsin K
    Protein for Human Cathepsin K

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Molecular cloning of human cathepsin O, a novel endoproteinase and homologue of rabbit OC2."
      Shi G.-P. , Chapman H.A. , Bhairi S.M. , Deleeuw C. , Reddy V.Y. , Weiss S.J.
      FEBS Lett.357:129-134(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Blood.
    2. 2.
      "Molecular cloning of human cDNA for cathepsin K: novel cysteine proteinase predominantly expressed in bone."
      Inaoka T. , Bilbe G. , Ishibashi O. , Tezuka K. , Kumegawa M. , Kokubo T.
      Biochem. Biophys. Res. Commun.206:89-96(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Bone.
    3. 3.
      "Cloning and complete coding sequence of a novel human cathepsin expressed in giant cells of osteoclastomas."
      Li Y. , Alexander M. , Wucherpfennig A.L. , Yelick P. , Chen W. , Stashenko P.
      J. Bone Miner. Res.10:1197-1202(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Osteoclastoma.
    4. 4.
      "Human cathepsin O2, a novel cysteine protease highly expressed in osteoclastomas and ovary molecular cloning, sequencing and tissue distribution."
      Broemme D. , Okamoto K.
      Biol. Chem. Hoppe-Seyler376:379-384(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Spleen.
    5. 5.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    6. 6.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Skin.
    9. 9.
      "Crystal structure of human cathepsin K complexed with a potent inhibitor."
      McGrath M.E. , Klaus J.L. , Barnes M.G. , Bromme D.
      Nat. Struct. Biol.4:105-109(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS)
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS)
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF ZYMOGEN FORM
    12. 12.
      "Crystal structure of wild-type human procathepsin K."
      Sivaraman J. , Lalumiere M. , Menard R. , Cygler M.
      Protein Sci.8:283-290(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS)
    13. 13.
      "Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency."
      Gelb B.D. , Shi G.-P. , Chapman H.A. , Desnick R.J.
      Science273:1236-1238(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PKND ARG-146
    14. 14.
      "Paternal uniparental disomy for chromosome 1 revealed by molecular analysis of a patient with pycnodysostosis."
      Gelb B.D. , Willner J.P. , Dunn T.M. , Kardon N.B. , Verloes A. , Poncin J. , Desnick R.J.
      Am. J. Hum. Genet.62:848-854(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PKND VAL-277
    15. 15.
      "Mutations of CTSK result in pycnodysostosis via a reduction in cathepsin K protein."
      Ho N. , Punturieri A. , Wilkin D. , Szabo J. , Johnson M. , Whaley J. , Davis J. , Clark A. , Weiss S. , Francomano C.
      J. Bone Miner. Res.14:1649-1653(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PKND GLU-79
    16. 16.
      "Cathepsin K gene mutations and 1q21 haplotypes in at patients with pycnodysostosis in an outbred population."
      Haagerup A. , Hertz J.M. , Christensen M.F. , Binderup H. , Kruse T.A.
      Eur. J. Hum. Genet.8:431-436(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PKND GLU-79 AND PRO-309
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