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Index > Protein center > CTH(Gene name) > Human
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  • CTH (Gene name),
  • Cystathionine gamma-lyase (Protein name ),  CGL_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    CTH;
    Protein name:
    Cystathionine gamma-lyase;
    Alternative:
    Gamma-cystathionase;Gamma-cystathionase;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homotetramer. Interacts with CALM in a calcium-dependent manner.
    Function:
    Catalyzes the last step in the transsulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    405
    Sequence:
    50:
    MQEKDASSQG | FLPHFQHFAT | QAIHVGQDPE | QWTSRAVVPP | ISLSTTFKQG | 
    100:
    APGQHSGFEY | SRSGNPTRNC | LEKAVAALDG | AKYCLAFASG | LAATVTITHL | 
    150:
    LKAGDQIICM | DDVYGGTNRY | FRQVASEFGL | KISFVDCSKI | KLLEAAITPE | 
    200:
    TKLVWIETPT | NPTQKVIDIE | GCAHIVHKHG | DIILVVDNTF | MSPYFQRPLA | 
    250:
    LGADISMYSA | TKYMNGHSDV | VMGLVSVNCE | SLHNRLRFLQ | NSLGAVPSPI | 
    300:
    DCYLCNRGLK | TLHVRMEKHF | KNGMAVAQFL | ESNPWVEKVI | YPGLPSHPQH | 
    350:
    ELVKRQCTGC | TGMVTFYIKG | TLQHAEIFLK | NLKLFTLAES | LGGFESLAEL | 
    400:
    PAIMTHASVL | KNDRDVLGIS | DTLIRLSVGL | EDEEDLLEDL | DQALKAAHPP | 
    405:
    SGSHS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    SMR:
    MIM:
    String:
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Cystathionine gamma-lyase
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    ELISA Kit for Human Cystathionine gamma-lyase
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    ELISA Kit for Human Cystathionine gamma-lyase
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    ELISA Kit for Human Cystathionine gamma-lyase
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    CLIA Kit for Human Cystathionine gamma-lyase
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    CLIA Kit for Human Cystathionine gamma-lyase
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    CLIA Kit for Human Cystathionine gamma-lyase
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    U1538m
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    Polyclonal Antibody for Human Cystathionine gamma-lyase
    Polyclonal Antibody for Human Cystathionine gamma-lyase
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    P1538Rb-m
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    Polyclonal Antibody for Human Cystathionine gamma-lyase
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    P1538Rb-r
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    Packing:
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    Polyclonal Antibody for Human Cystathionine gamma-lyase
    Polyclonal Antibody for Human Cystathionine gamma-lyase
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    P1538Rb-h
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Cystathionine gamma-lyase
    Monoclonal Antibody for Human Cystathionine gamma-lyase
    Monoclonal Antibody for Human Cystathionine gamma-lyase
    Monoclonal Antibody for Human Cystathionine gamma-lyase
    Monoclonal Antibody for Human Cystathionine gamma-lyase
    Protein for Human Cystathionine gamma-lyase
    Protein for Human Cystathionine gamma-lyase
    Protein for Human Cystathionine gamma-lyase
    Protein for Human Cystathionine gamma-lyase
    Protein for Human Cystathionine gamma-lyase

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    References
    1. 1.
      "Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine gamma-lyase."
      Lu Y. , O'Dowd B.F. , Orrego H. , Israel Y.
      Biochem. Biophys. Res. Commun.189:749-758(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);VARIANT ILE-403
      tissue: Liver.
    2. 2.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3);VARIANT ILE-403
      tissue: Trachea.
    4. 4.
      Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
      Submitted (2005-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ILE-403
      tissue: Kidney.
    5. 5.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Skin.
    8. 8.
      "Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration."
      Steegborn C. , Clausen T. , Sondermann P. , Jacob U. , Worbs M. , Marinkovic S. , Huber R. , Wahl M.C.
      J. Biol. Chem.274:12675-12684(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY;SUBUNIT;COFACTOR;ENZYME REGULATION;BIOPHYSICOCHEMICAL PROPERTIES
    9. 9.
      "H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia."
      Chiku T. , Padovani D. , Zhu W. , Singh S. , Vitvitsky V. , Banerjee R.
      J. Biol. Chem.284:11601-11612(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    11. 11.
      "H2s-induced sulfhydration of the phosphatase PTP1B and its role in the endoplasmic reticulum stress response."
      Krishnan N. , Fu C. , Pappin D.J. , Tonks N.K.
      Sci. Signal.4:RA86-RA86(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS CYSTEINE-PROTEIN SULFHYDRASE
    12. 12.
      "Structural basis for the inhibition mechanism of human cystathionine gamma-lyase, an enzyme responsible for the production of H(2)S."
      Sun Q. , Collins R. , Huang S. , Holmberg-Schiavone L. , Anand G.S. , Tan C.-H. , van-den-Berg S. , Deng L.-W. , Moore P.K. , Karlberg T. , Sivaraman J.
      J. Biol. Chem.284:3076-3085(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 1-402 IN COMPLEXES WITH PYRODOXAL PHOSPHATE; NITRATE AND PROPARGYLGLYCINE;FUNCTION;SUBUNIT;ENZYME REGULATION;CATALYTIC ACTIVITY;COFACTOR
    13. 13.
      "Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH)."
      Wang J. , Hegele R.A.
      Hum. Genet.112:404-408(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CSTNU ILE-67 AND GLU-240;VARIANT ILE-403
    14. 14.
      "Kinetic properties of polymorphic variants and pathogenic mutants in human cystathionine gamma-lyase."
      Zhu W. , Lin A. , Banerjee R.
      Biochemistry47:6226-6232(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANTS CSTNU ILE-67 AND GLU-240;COFACTOR;BIOPHYSICOCHEMICAL PROPERTIES;SUBUNIT
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