Protein name:
Complement C2 ;
Alternative:
C3/C5 convertase ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
C2a interacts with Schistosoma haematobium TOR (via N-terminal extracellular domain). This results in inhibition of the classical and lectin pathway of complement activation, probably due to interference with binding of C2a to C4b such that C3 convertase cannot be formed. This infers resistance to complement-mediated cell lysis, allowing parasite survival and infection.
Function:
Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor 4b to generate the C3 or C5 convertase.
Subcellular Location:
Secreted
Protein Attributes:
50:
MGPLMVLFCL | LFLYPGLADS | APSCPQNVNI | SGGTFTLSHG | WAPGSLLTYS |
100:
CPQGLYPSPA | SRLCKSSGQW | QTPGATRSLS | KAVCKPVRCP | APVSFENGIY |
150:
TPRLGSYPVG | GNVSFECEDG | FILRGSPVRQ | CRPNGMWDGE | TAVCDNGAGH |
200:
CPNPGISLGA | VRTGFRFGHG | DKVRYRCSSN | LVLTGSSERE | CQGNGVWSGT |
250:
EPICRQPYSY | DFPEDVAPAL | GTSFSHMLGA | TNPTQKTKES | LGRKIQIQRS |
300:
GHLNLYLLLD | CSQSVSENDF | LIFKESASLM | VDRIFSFEIN | VSVAIITFAS |
350:
EPKVLMSVLN | DNSRDMTEVI | SSLENANYKD | HENGTGTNTY | AALNSVYLMM |
400:
NNQMRLLGME | TMAWQEIRHA | IILLTDGKSN | MGGSPKTAVD | HIREILNINQ |
450:
KRNDYLDIYA | IGVGKLDVDW | RELNELGSKK | DGERHAFILQ | DTKALHQVFE |
500:
HMLDVSKLTD | TICGVGNMSA | NASDQERTPW | HVTIKPKSQE | TCRGALISDQ |
550:
WVLTAAHCFR | DGNDHSLWRV | NVGDPKSQWG | KEFLIEKAVI | SPGFDVFAKK |
600:
NQGILEFYGD | DIALLKLAQK | VKMSTHARPI | CLPCTMEANL | ALRRPQGSTC |
650:
RDHENELLNK | QSVPAHFVAL | NGSKLNINLK | MGVEWTSCAE | VVSQEKTMFP |
700:
NLTDVREVVT | DQFLCSGTQE | DESPCKGESG | GAVFLERRFR | FFQVGLVSWG |
750:
LYNPCLGSAD | KNSRKRAPRS | KVPPPRDFHI | NLFRMQPWLR | QHLGDVLNFL |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Bovine
ELISA Kit for Human Complement C2
ELISA Kit for Human Complement C2
ELISA Kit for Human Complement C2
CLIA Kit for Human Complement C2
CLIA Kit for Human Complement C2
CLIA Kit for Human Complement C2
Polyclonal Antibody for Human Complement C2
Polyclonal Antibody for Human Complement C2
Polyclonal Antibody for Human Complement C2
Monoclonal Antibody for Human Complement C2
Monoclonal Antibody for Human Complement C2
Monoclonal Antibody for Human Complement C2
Protein for Human Complement C2
Protein for Human Complement C2
Protein for Human Complement C2
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
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Liver .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
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Liver .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3)
tissue :
Kidney .
tissue :
Small intestine .
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Brain .
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 21-46 AND 244-256
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 21-46
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 21-28;INTERACTION WITH SCHISTOSOMA HAEMATOBIUM TOR
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 137-171; 454-466 AND 574-717
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 244-269
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 588-717 (ISOFORM 1)
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 694-752
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-112; ASN-333; ASN-467; ASN-471; ASN-621 AND ASN-651
tissue :
Plasma .
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-112 AND ASN-333
tissue :
Liver .
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 244-752;GLYCOSYLATION AT ASN-333; ASN-467 AND ASN-621;MIDAS-LIKE MOTIF;METAL-BINDING SITES;ACTIVE SITE;DISULFIDE BONDS
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 21-243;DISULFIDE BONDS
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT C2D TYR-131
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Nat. Genet.38:458-462(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT ASP-318;INVOLVEMENT IN REDUCED RISK OF ARMD