C2 ELISA Kit for Human(Homo sapiens) | EIAab.comC2 ELISA Kit for Human(Homo sapiens)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > C2(Gene name) > Human

C2 (Gene name),

Complement C2 (Protein name ), CO2_HUMAN from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

C2;

Protein name:

Complement C2;

Alternative:

C3/C5 convertase;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

C2a interacts with Schistosoma haematobium TOR (via N-terminal extracellular domain). This results in inhibition of the classical and lectin pathway of complement activation, probably due to interference with binding of C2a to C4b such that C3 convertase cannot be formed. This infers resistance to complement-mediated cell lysis, allowing parasite survival and infection.

Function:

Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor 4b to generate the C3 or C5 convertase.

Subcellular Location:

Secreted

Protein Attributes:

Sequence length:

752

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

752:

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

SMR:

P06681

MIM:

217000

KEGG:

hsa:717

UniGene:

Hs.408903

String:

P06681

STRING:

9606.ENSP00000372853

Pfam:

PF00084

Uniprot:

P06681

FOR

ELISA Kit for Human Complement C2

Cat.:

E1794h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human Complement C2

Cat.:

E1794m

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human Complement C2

Cat.:

E1794b

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Complement C2

Cat.:

U1794b

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Complement C2

Cat.:

U1794h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

CLIA Kit for Human Complement C2

Cat.:

U1794m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

Polyclonal Antibody for Human Complement C2

Cat.:

P1794Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human Complement C2

Cat.:

P1794Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Human Complement C2

Protein for Human Complement C2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Primary structure of human complement component C2. Homology to two unrelated protein families."
Bentley D.R.
Biochem. J.239:339-345(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Liver.
2.

"cDNA cloning and expression of human complement component C2."
Horiuchi T. , Macon K.J. , Kidd V.J. , Volanakis J.E.
J. Immunol.142:2105-2111(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Liver.
3.

"Structure of the human C2 gene."
Ishii Y. , Zhu Z.B. , Macon K.J. , Volanakis J.E.
J. Immunol.151:170-174(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.

"Sequence determination of 300 kilobases of the human class III MHC locus."
Rowen L. , Dankers C. , Baskin D. , Faust J. , Loretz C. , Ahearn M.E. , Banta A. , Swartzell S. , Smith T.M. , Spies T. , Hood L.
Submitted (1997-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
5.

SeattleSNPs variation discovery resource
Submitted (2003-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ASP-318 AND CYS-734
6.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3)
tissue: Kidney.
tissue: Small intestine.
7.

"The DNA sequence and analysis of human chromosome 6."
Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Brain.
9.

"The purification and properties of the second component of guinea-pig complement."
Kerr M.A. , Gagnon J.
Biochem. J.205:59-67(1982) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 21-46 AND 244-256
10.

"DNA polymorphism of the C2 locus."
Bentley D.R. , Campbell R.D. , Cross S.J.
Immunogenetics22:377-390(1985) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 21-46
11.

"A Schistosoma protein, Sh-TOR, is a novel inhibitor of complement which binds human C2."
Inal J.M. , Sim R.B.
FEBS Lett.470:131-134(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 21-28;INTERACTION WITH SCHISTOSOMA HAEMATOBIUM TOR
12.

"Structure and activation of complement components C2 and factor B."
Gagnon J.
Philos. Trans. R. Soc. Lond., B, Biol. Sci.306:301-309(1984) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 137-171; 454-466 AND 574-717
13.

"The reaction of iodine and thiol-blocking reagents with human complement components C2 and factor B. Purification and N-terminal amino acid sequence of a peptide from C2a containing a free thiol group."
Parkes C. , Gagnon J. , Kerr M.A.
Biochem. J.213:201-209(1983) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 244-269
14.

"Isolation of cDNA clones for human complement component C2."
Bentley D.R. , Porter R.R.
Proc. Natl. Acad. Sci. U.S.A.81:1212-1215(1984) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 588-717 (ISOFORM 1)
15.

"Cell-specific expression of the human complement protein factor B gene: evidence for the role of two distinct 5'-flanking elements."
Wu L.C. , Morley B.J. , Campbell R.D.
Cell48:331-342(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 694-752
16.

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-112; ASN-333; ASN-467; ASN-471; ASN-621 AND ASN-651
tissue: Plasma.
17.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-112 AND ASN-333
tissue: Liver.
18.

"Structure of complement component C2A: implications for convertase formation and substrate binding."
Milder F.J. , Raaijmakers H.C. , Vandeputte M.D. , Schouten A. , Huizinga E.G. , Romijn R.A. , Hemrika W. , Roos A. , Daha M.R. , Gros P.
Structure14:1587-1597(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 244-752;GLYCOSYLATION AT ASN-333; ASN-467 AND ASN-621;MIDAS-LIKE MOTIF;METAL-BINDING SITES;ACTIVE SITE;DISULFIDE BONDS
19.

"The structure of C2b, a fragment of complement component C2 produced during C3 convertase formation."
Krishnan V. , Xu Y. , Macon K. , Volanakis J.E. , Narayana S.V.
Acta Crystallogr. D65:266-274(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 21-243;DISULFIDE BONDS
20.

"Type II human complement C2 deficiency. Allele-specific amino acid substitutions (Ser189 --> Phe; Gly444 --> Arg) cause impaired C2 secretion."
Wetsel R.A. , Kulics J. , Lokki M.L. , Kiepiela P. , Akama H. , Johnson C.A. , Densen P. , Colten H.R.
J. Biol. Chem.271:5824-5831(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS C2D PHE-209 AND ARG-464
21.

"A novel type II complement C2 deficiency allele in an African-American family."
Zhu Z.B. , Atkinson T.P. , Volanakis J.E.
J. Immunol.161:578-584(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT C2D TYR-131
22.

"Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration."
Gold B. , Merriam J.E. , Zernant J. , Hancox L.S. , Taiber A.J. , Gehrs K. , Cramer K. , Neel J. , Bergeron J. , Barile G.R. , Smith R.T. , Hageman G.S. , Dean M. , Allikmets R.
Nat. Genet.38:458-462(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ASP-318;INVOLVEMENT IN REDUCED RISK OF ARMD

Product Feedback Wall

* Email:
*Comments: