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Index > Protein center > C2(Gene name) > Human
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  • C2 (Gene name),
  • Complement C2 (Protein name ),  CO2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    C2;
    Protein name:
    Complement C2;
    Alternative:
    C3/C5 convertase;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    C2a interacts with Schistosoma haematobium TOR (via N-terminal extracellular domain). This results in inhibition of the classical and lectin pathway of complement activation, probably due to interference with binding of C2a to C4b such that C3 convertase cannot be formed. This infers resistance to complement-mediated cell lysis, allowing parasite survival and infection.
    Function:
    Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor 4b to generate the C3 or C5 convertase.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    752
    Sequence:
    50:
    MGPLMVLFCL | LFLYPGLADS | APSCPQNVNI | SGGTFTLSHG | WAPGSLLTYS | 
    100:
    CPQGLYPSPA | SRLCKSSGQW | QTPGATRSLS | KAVCKPVRCP | APVSFENGIY | 
    150:
    TPRLGSYPVG | GNVSFECEDG | FILRGSPVRQ | CRPNGMWDGE | TAVCDNGAGH | 
    200:
    CPNPGISLGA | VRTGFRFGHG | DKVRYRCSSN | LVLTGSSERE | CQGNGVWSGT | 
    250:
    EPICRQPYSY | DFPEDVAPAL | GTSFSHMLGA | TNPTQKTKES | LGRKIQIQRS | 
    300:
    GHLNLYLLLD | CSQSVSENDF | LIFKESASLM | VDRIFSFEIN | VSVAIITFAS | 
    350:
    EPKVLMSVLN | DNSRDMTEVI | SSLENANYKD | HENGTGTNTY | AALNSVYLMM | 
    400:
    NNQMRLLGME | TMAWQEIRHA | IILLTDGKSN | MGGSPKTAVD | HIREILNINQ | 
    450:
    KRNDYLDIYA | IGVGKLDVDW | RELNELGSKK | DGERHAFILQ | DTKALHQVFE | 
    500:
    HMLDVSKLTD | TICGVGNMSA | NASDQERTPW | HVTIKPKSQE | TCRGALISDQ | 
    550:
    WVLTAAHCFR | DGNDHSLWRV | NVGDPKSQWG | KEFLIEKAVI | SPGFDVFAKK | 
    600:
    NQGILEFYGD | DIALLKLAQK | VKMSTHARPI | CLPCTMEANL | ALRRPQGSTC | 
    650:
    RDHENELLNK | QSVPAHFVAL | NGSKLNINLK | MGVEWTSCAE | VVSQEKTMFP | 
    700:
    NLTDVREVVT | DQFLCSGTQE | DESPCKGESG | GAVFLERRFR | FFQVGLVSWG | 
    750:
    LYNPCLGSAD | KNSRKRAPRS | KVPPPRDFHI | NLFRMQPWLR | QHLGDVLNFL | 
    752:
    PL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    MIM:
    KEGG:
    UniGene:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Complement C2
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    ELISA Kit for Human Complement C2
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    E1794m
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    ELISA Kit for Human Complement C2
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    E1794b
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    Packing:
    96T
    CLIA Kit for Human Complement C2
    Cat.:
    U1794b
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    Packing:
    96T
    CLIA Kit for Human Complement C2
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    U1794h
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    96T
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    CLIA Kit for Human Complement C2
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    U1794m
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Complement C2
    Cat.:
    P1794Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Complement C2
    Polyclonal Antibody for Human Complement C2
    Cat.:
    P1794Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Complement C2
    Monoclonal Antibody for Human Complement C2
    Monoclonal Antibody for Human Complement C2
    Protein for Human Complement C2
    Protein for Human Complement C2
    Protein for Human Complement C2

    R&D Technical Data
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    Recovery
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    Linearity
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    References
    1. 1.
      "Primary structure of human complement component C2. Homology to two unrelated protein families."
      Bentley D.R.
      Biochem. J.239:339-345(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Liver.
    2. 2.
      "cDNA cloning and expression of human complement component C2."
      Horiuchi T. , Macon K.J. , Kidd V.J. , Volanakis J.E.
      J. Immunol.142:2105-2111(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Liver.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      "Sequence determination of 300 kilobases of the human class III MHC locus."
      Rowen L. , Dankers C. , Baskin D. , Faust J. , Loretz C. , Ahearn M.E. , Banta A. , Swartzell S. , Smith T.M. , Spies T. , Hood L.
      Submitted (1997-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    5. 5.
      SeattleSNPs variation discovery resource
      Submitted (2003-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ASP-318 AND CYS-734
    6. 6.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3)
      tissue: Kidney.
      tissue: Small intestine.
    7. 7.
      "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    9. 9.
      "The purification and properties of the second component of guinea-pig complement."
      Kerr M.A. , Gagnon J.
      Biochem. J.205:59-67(1982) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 21-46 AND 244-256
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 21-46
    11. 11.
      "A Schistosoma protein, Sh-TOR, is a novel inhibitor of complement which binds human C2."
      Inal J.M. , Sim R.B.
      FEBS Lett.470:131-134(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 21-28;INTERACTION WITH SCHISTOSOMA HAEMATOBIUM TOR
    12. 12.
      "Structure and activation of complement components C2 and factor B."
      Gagnon J.
      Philos. Trans. R. Soc. Lond., B, Biol. Sci.306:301-309(1984) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 137-171; 454-466 AND 574-717
    13. 13.
      "The reaction of iodine and thiol-blocking reagents with human complement components C2 and factor B. Purification and N-terminal amino acid sequence of a peptide from C2a containing a free thiol group."
      Parkes C. , Gagnon J. , Kerr M.A.
      Biochem. J.213:201-209(1983) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 244-269
    14. 14.
      "Isolation of cDNA clones for human complement component C2."
      Bentley D.R. , Porter R.R.
      Proc. Natl. Acad. Sci. U.S.A.81:1212-1215(1984) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 588-717 (ISOFORM 1)
    15. 15.
      "Cell-specific expression of the human complement protein factor B gene: evidence for the role of two distinct 5'-flanking elements."
      Wu L.C. , Morley B.J. , Campbell R.D.
      Cell48:331-342(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 694-752
    16. 16.
      "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
      J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-112; ASN-333; ASN-467; ASN-471; ASN-621 AND ASN-651
      tissue: Plasma.
    17. 17.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-112 AND ASN-333
      tissue: Liver.
    18. 18.
      "Structure of complement component C2A: implications for convertase formation and substrate binding."
      Milder F.J. , Raaijmakers H.C. , Vandeputte M.D. , Schouten A. , Huizinga E.G. , Romijn R.A. , Hemrika W. , Roos A. , Daha M.R. , Gros P.
      Structure14:1587-1597(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 244-752;GLYCOSYLATION AT ASN-333; ASN-467 AND ASN-621;MIDAS-LIKE MOTIF;METAL-BINDING SITES;ACTIVE SITE;DISULFIDE BONDS
    19. 19.
      "The structure of C2b, a fragment of complement component C2 produced during C3 convertase formation."
      Krishnan V. , Xu Y. , Macon K. , Volanakis J.E. , Narayana S.V.
      Acta Crystallogr. D65:266-274(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 21-243;DISULFIDE BONDS
    20. 20.
      "Type II human complement C2 deficiency. Allele-specific amino acid substitutions (Ser189 --> Phe; Gly444 --> Arg) cause impaired C2 secretion."
      Wetsel R.A. , Kulics J. , Lokki M.L. , Kiepiela P. , Akama H. , Johnson C.A. , Densen P. , Colten H.R.
      J. Biol. Chem.271:5824-5831(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS C2D PHE-209 AND ARG-464
    21. 21.
      "A novel type II complement C2 deficiency allele in an African-American family."
      Zhu Z.B. , Atkinson T.P. , Volanakis J.E.
      J. Immunol.161:578-584(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT C2D TYR-131
    22. 22.
      "Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration."
      Gold B. , Merriam J.E. , Zernant J. , Hancox L.S. , Taiber A.J. , Gehrs K. , Cramer K. , Neel J. , Bergeron J. , Barile G.R. , Smith R.T. , Hageman G.S. , Dean M. , Allikmets R.
      Nat. Genet.38:458-462(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ASP-318;INVOLVEMENT IN REDUCED RISK OF ARMD
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