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Index > Protein center > C8A(Gene name) > Human
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  • C8A (Gene name),
  • Complement component C8 alpha chain (Protein name ),  CO8A_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    C8A;
    Protein name:
    Complement component C8 alpha chain;
    Alternative:
    Complement component 8 subunit alpha;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Heterotrimer of 3 chains: alpha, beta and gamma. The alpha and gamma chains are disulfide bonded. Component of the membrane attack complex (MAC). MAC assembly is initiated by protelytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and multiple copies of the pore-forming subunit C9.
    Function:
    Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself.
    Subcellular Location:
    Secreted Cell membrane Multi-pass membrane protein Secreted as soluble protein. Inserts into the cell membrane of target cells.
    Protein Attributes:
    Sequence length:
    584
    Sequence:
    50:
    MFAVVFFILS | LMTCQPGVTA | QEKVNQRVRR | AATPAAVTCQ | LSNWSEWTDC | 
    100:
    FPCQDKKYRH | RSLLQPNKFG | GTICSGDIWD | QASCSSSTTC | VRQAQCGQDF | 
    150:
    QCKETGRCLK | RHLVCNGDQD | CLDGSDEDDC | EDVRAIDEDC | SQYEPIPGSQ | 
    200:
    KAALGYNILT | QEDAQSVYDA | SYYGGQCETV | YNGEWRELRY | DSTCERLYYG | 
    250:
    DDEKYFRKPY | NFLKYHFEAL | ADTGISSEFY | DNANDLLSKV | KKDKSDSFGV | 
    300:
    TIGIGPAGSP | LLVGVGVSHS | QDTSFLNELN | KYNEKKFIFT | RIFTKVQTAH | 
    350:
    FKMRKDDIML | DEGMLQSLME | LPDQYNYGMY | AKFINDYGTH | YITSGSMGGI | 
    400:
    YEYILVIDKA | KMESLGITSR | DITTCFGGSL | GIQYEDKINV | GGGLSGDHCK | 
    450:
    KFGGGKTERA | RKAMAVEDII | SRVRGGSSGW | SGGLAQNRST | ITYRSWGRSL | 
    500:
    KYNPVVIDFE | MQPIHEVLRH | TSLGPLEAKR | QNLRRALDQY | LMEFNACRCG | 
    550:
    PCFNNGVPIL | EGTSCRCQCR | LGSLGAACEQ | TQTEGAKADG | SWSCWSSWSV | 
    584:
    CRAGIQERRR | ECDNPAPQNG | GASCPGRKVQ | TQAC
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    KEGG:
    Pfam:
    MIM:
    UniGene:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Complement component C8 alpha chain
    MSDS:
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    ELISA Kit for Human Complement component C8 alpha chain
    Cat.:
    E1970h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human Complement component C8 alpha chain
    Cat.:
    E1970m
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Complement component C8 alpha chain
    Cat.:
    U1970m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Complement component C8 alpha chain
    Cat.:
    U1970h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Complement component C8 alpha chain
    MSDS:
    Please sign in first.
    Polyclonal Antibody for Human Complement component C8 alpha chain
    Cat.:
    P1970Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Complement component C8 alpha chain
    Polyclonal Antibody for Human Complement component C8 alpha chain
    Cat.:
    P1970Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Complement component C8 alpha chain
    Monoclonal Antibody for Human Complement component C8 alpha chain
    Monoclonal Antibody for Human Complement component C8 alpha chain
    Protein for Human Complement component C8 alpha chain
    Protein for Human Complement component C8 alpha chain
    Protein for Human Complement component C8 alpha chain

    R&D Technical Data
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Complementary DNA and derived amino acid sequence of the alpha subunit of human complement protein C8: evidence for the existence of a separate alpha subunit messenger RNA."
      Rao A.G. , Howard O.M.Z. , Ng S.C. , Whitehead A.S. , Colten H.R. , Sodetz J.M.
      Biochemistry26:3556-3564(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE
      tissue: Liver.
    2. 2.
      Sodetz J.M.
      Submitted (1993-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION TO 467-479
    3. 3.
      "Genomic organization of human complement protein C8 alpha and further examination of its linkage to C8 beta."
      Michelotti G.A. , Snider J.V. , Sodetz J.M.
      Hum. Genet.95:513-518(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      tissue: Blood.
    4. 4.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT LYS-93
    6. 6.
      "The eighth component of human complement. Purification and physicochemical characterization of its unusual subunit structure."
      Steckel E.W. , York R.G. , Monahan J.B. , Sodetz J.M.
      J. Biol. Chem.255:11997-12005(1980) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE;FUNCTION;SUBUNIT
    7. 7.
      "The four terminal components of the complement system are C-mannosylated on multiple tryptophan residues."
      Hofsteenge J. , Blommers M. , Hess D. , Furmanek A. , Miroshnichenko O.
      J. Biol. Chem.274:32786-32794(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT TRP-44; TRP-542; TRP-545 AND TRP-548
    8. 8.
      "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
      J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-437
      tissue: Plasma.
    9. 9.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-437
      tissue: Liver.
    10. 10.
      "Structure of C8alpha-MACPF reveals mechanism of membrane attack in complement immune defense."
      Hadders M.A. , Beringer D.X. , Gros P.
      Science317:1552-1554(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 133-492;FUNCTION
    11. 11.
      "Crystal structure of the MACPF domain of human complement protein C8 alpha in complex with the C8 gamma subunit."
      Slade D.J. , Lovelace L.L. , Chruszcz M. , Minor W. , Lebioda L. , Sodetz J.M.
      J. Mol. Biol.379:331-342(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) OF 133-492 IN COMPLEX WITH C8G;INTERCHAIN DISULFIDE BOND
    12. 12.
      "Crystal structure of complement protein C8gamma in complex with a peptide containing the C8gamma binding site on C8alpha: implications for C8gamma ligand binding."
      Lovelace L.L. , Chiswell B. , Slade D.J. , Sodetz J.M. , Lebioda L.
      Mol. Immunol.45:750-756(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.81 ANGSTROMS) OF 188-198 IN COMPLEX WITH C8G
    13. 13.
      "The eighth component of human complement: molecular basis of C8A (C81) polymorphism."
      Zhang L. , Rittner C. , Sodetz J.M. , Schneider P.M. , Kaufmann T.
      Hum. Genet.96:281-284(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT C8A*B LYS-93
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