C8A ELISA Kit for Human(Homo sapiens) | EIAab.comC8A ELISA Kit for Human(Homo sapiens)

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Index > Protein center > C8A(Gene name) > Human

C8A (Gene name),

Complement component C8 alpha chain (Protein name ), CO8A_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

C8A;

Protein name:

Complement component C8 alpha chain;

Alternative:

Complement component 8 subunit alpha;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Heterotrimer of 3 chains: alpha, beta and gamma. The alpha and gamma chains are disulfide bonded. Component of the membrane attack complex (MAC). MAC assembly is initiated by protelytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and multiple copies of the pore-forming subunit C9.

Function:

Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself.

Subcellular Location:

Secreted Cell membrane Multi-pass membrane protein Secreted as soluble protein. Inserts into the cell membrane of target cells.

Protein Attributes:

Sequence length:

584

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

584:

CRAGIQERRR | ECDNPAPQNG | GASCPGRKVQ | TQAC

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P07357

KEGG:

hsa:731

STRING:

9606.ENSP00000354458

Pfam:

PF00057

MIM:

120950

UniGene:

Hs.93210

String:

P07357

Uniprot:

P07357

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ELISA Kit for Human Complement component C8 alpha chain

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ELISA Kit for Human Complement component C8 alpha chain

Cat.:

E1970h

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Manual:

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Packing:

96T

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ELISA Kit for Human Complement component C8 alpha chain

Cat.:

E1970m

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Packing:

96T

CLIA Kit for Human Complement component C8 alpha chain

Cat.:

U1970m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human Complement component C8 alpha chain

Cat.:

U1970h

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Human Complement component C8 alpha chain

MSDS:

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Polyclonal Antibody for Human Complement component C8 alpha chain

Cat.:

P1970Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Complement component C8 alpha chain

Cat.:

P1970Rb-m

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Complement component C8 alpha chain

Protein for Human Complement component C8 alpha chain

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Complementary DNA and derived amino acid sequence of the alpha subunit of human complement protein C8: evidence for the existence of a separate alpha subunit messenger RNA."
Rao A.G. , Howard O.M.Z. , Ng S.C. , Whitehead A.S. , Colten H.R. , Sodetz J.M.
Biochemistry26:3556-3564(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE
tissue: Liver.
2.

Sodetz J.M.
Submitted (1993-02) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION TO 467-479
3.

"Genomic organization of human complement protein C8 alpha and further examination of its linkage to C8 beta."
Michelotti G.A. , Snider J.V. , Sodetz J.M.
Hum. Genet.95:513-518(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
tissue: Blood.
4.

"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT LYS-93
6.

"The eighth component of human complement. Purification and physicochemical characterization of its unusual subunit structure."
Steckel E.W. , York R.G. , Monahan J.B. , Sodetz J.M.
J. Biol. Chem.255:11997-12005(1980) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE;FUNCTION;SUBUNIT
7.

"The four terminal components of the complement system are C-mannosylated on multiple tryptophan residues."
Hofsteenge J. , Blommers M. , Hess D. , Furmanek A. , Miroshnichenko O.
J. Biol. Chem.274:32786-32794(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT TRP-44; TRP-542; TRP-545 AND TRP-548
8.

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-437
tissue: Plasma.
9.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-437
tissue: Liver.
10.

"Structure of C8alpha-MACPF reveals mechanism of membrane attack in complement immune defense."
Hadders M.A. , Beringer D.X. , Gros P.
Science317:1552-1554(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 133-492;FUNCTION
11.

"Crystal structure of the MACPF domain of human complement protein C8 alpha in complex with the C8 gamma subunit."
Slade D.J. , Lovelace L.L. , Chruszcz M. , Minor W. , Lebioda L. , Sodetz J.M.
J. Mol. Biol.379:331-342(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) OF 133-492 IN COMPLEX WITH C8G;INTERCHAIN DISULFIDE BOND
12.

"Crystal structure of complement protein C8gamma in complex with a peptide containing the C8gamma binding site on C8alpha: implications for C8gamma ligand binding."
Lovelace L.L. , Chiswell B. , Slade D.J. , Sodetz J.M. , Lebioda L.
Mol. Immunol.45:750-756(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.81 ANGSTROMS) OF 188-198 IN COMPLEX WITH C8G
13.

"The eighth component of human complement: molecular basis of C8A (C81) polymorphism."
Zhang L. , Rittner C. , Sodetz J.M. , Schneider P.M. , Kaufmann T.
Hum. Genet.96:281-284(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT C8A*B LYS-93

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