Protein name:
Complement component C9 ;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Component of the membrane attack complex (MAC). MAC assembly is initiated by protelytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and multiple copies of the pore-forming subunit C9.
Function:
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC.
Subcellular Location:
Secreted
Cell membrane
Multi-pass membrane protein
Secreted as soluble monomer. Oligomerizes at target membranes, forming a pre-pore. A conformation change then leads to the formation of a 100 Angstrom diameter pore.
Protein Attributes:
50:
MSACRSFAVA | ICILEISILT | AQYTTSYDPE | LTESSGSASH | IDCRMSPWSE |
100:
WSQCDPCLRQ | MFRSRSIEVF | GQFNGKRCTD | AVGDRRQCVP | TEPCEDAEDD |
150:
CGNDFQCSTG | RCIKMRLRCN | GDNDCGDFSD | EDDCESEPRP | PCRDRVVEES |
200:
ELARTAGYGI | NILGMDPLST | PFDNEFYNGL | CNRDRDGNTL | TYYRRPWNVA |
250:
SLIYETKGEK | NFRTEHYEEQ | IEAFKSIIQE | KTSNFNAAIS | LKFTPTETNK |
300:
AEQCCEETAS | SISLHGKGSF | RFSYSKNETY | QLFLSYSSKK | EKMFLHVKGE |
350:
IHLGRFVMRN | RDVVLTTTFV | DDIKALPTTY | EKGEYFAFLE | TYGTHYSSSG |
400:
SLGGLYELIY | VLDKASMKRK | GVELKDIKRC | LGYHLDVSLA | FSEISVGAEF |
450:
NKDDCVKRGE | GRAVNITSEN | LIDDVVSLIR | GGTRKYAFEL | KEKLLRGTVI |
500:
DVTDFVNWAS | SINDAPVLIS | QKLSPIYNLV | PVKMKNAHLK | KQNLERAIED |
550:
YINEFSVRKC | HTCQNGGTVI | LMDGKCLCAC | PFKFEGIACE | ISKQKISEGL |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Bovine
Rat
Mouse
Rabbit
ELISA Kit for Human Complement component C9
ELISA Kit for Human Complement component C9
ELISA Kit for Human Complement component C9
ELISA Kit for Human Complement component C9
ELISA Kit for Human Complement component C9
CLIA Kit for Human Complement component C9
CLIA Kit for Human Complement component C9
CLIA Kit for Human Complement component C9
CLIA Kit for Human Complement component C9
CLIA Kit for Human Complement component C9
Polyclonal Antibody for Human Complement component C9
Polyclonal Antibody for Human Complement component C9
Polyclonal Antibody for Human Complement component C9
Polyclonal Antibody for Human Complement component C9
Polyclonal Antibody for Human Complement component C9
Monoclonal Antibody for Human Complement component C9
Monoclonal Antibody for Human Complement component C9
Monoclonal Antibody for Human Complement component C9
Monoclonal Antibody for Human Complement component C9
Monoclonal Antibody for Human Complement component C9
Protein for Human Complement component C9
Protein for Human Complement component C9
Protein for Human Complement component C9
Protein for Human Complement component C9
Protein for Human Complement component C9
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Liver .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 2-559;PROTEIN SEQUENCE OF N-TERMINUS
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 62-159
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 27-559;VARIANT C9D GLY-119
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PARTIAL PROTEIN SEQUENCE;ELECTRON MICROSCOPY;GLYCOSYLATION AT ASN-277 AND ASN-415
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DISULFIDE BONDS
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION AT TRP-48 AND TRP-51
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-415
tissue :
Plasma .
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-277 AND ASN-415
tissue :
Plasma .
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-415
tissue :
Platelet .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-277 AND ASN-415
tissue :
Liver .
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14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : 3D-STRUCTURE MODELING OF MEMBRANE-SPANNING DOMAIN (MSB)
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"Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration."
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT ARMD15 SER-167