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Index > Protein center > C9(Gene name) > Human
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  • C9 (Gene name),
  • Complement component C9 (Protein name ),  CO9_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    C9;
    Protein name:
    Complement component C9;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Component of the membrane attack complex (MAC). MAC assembly is initiated by protelytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and multiple copies of the pore-forming subunit C9.
    Function:
    Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC.
    Subcellular Location:
    Secreted Cell membrane Multi-pass membrane protein Secreted as soluble monomer. Oligomerizes at target membranes, forming a pre-pore. A conformation change then leads to the formation of a 100 Angstrom diameter pore.
    Protein Attributes:
    Sequence length:
    559
    Sequence:
    50:
    MSACRSFAVA | ICILEISILT | AQYTTSYDPE | LTESSGSASH | IDCRMSPWSE | 
    100:
    WSQCDPCLRQ | MFRSRSIEVF | GQFNGKRCTD | AVGDRRQCVP | TEPCEDAEDD | 
    150:
    CGNDFQCSTG | RCIKMRLRCN | GDNDCGDFSD | EDDCESEPRP | PCRDRVVEES | 
    200:
    ELARTAGYGI | NILGMDPLST | PFDNEFYNGL | CNRDRDGNTL | TYYRRPWNVA | 
    250:
    SLIYETKGEK | NFRTEHYEEQ | IEAFKSIIQE | KTSNFNAAIS | LKFTPTETNK | 
    300:
    AEQCCEETAS | SISLHGKGSF | RFSYSKNETY | QLFLSYSSKK | EKMFLHVKGE | 
    350:
    IHLGRFVMRN | RDVVLTTTFV | DDIKALPTTY | EKGEYFAFLE | TYGTHYSSSG | 
    400:
    SLGGLYELIY | VLDKASMKRK | GVELKDIKRC | LGYHLDVSLA | FSEISVGAEF | 
    450:
    NKDDCVKRGE | GRAVNITSEN | LIDDVVSLIR | GGTRKYAFEL | KEKLLRGTVI | 
    500:
    DVTDFVNWAS | SINDAPVLIS | QKLSPIYNLV | PVKMKNAHLK | KQNLERAIED | 
    550:
    YINEFSVRKC | HTCQNGGTVI | LMDGKCLCAC | PFKFEGIACE | ISKQKISEGL | 
    559:
    PALEFPNEK
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    KEGG:
    UniGene:
    String:
    Pfam:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Complement component C9
    Cat.:
    E14963h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Complement component C9
    MSDS:
    Please sign in first.
    ELISA Kit for Human Complement component C9
    MSDS:
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    ELISA Kit for Human Complement component C9
    Cat.:
    E14963m
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human Complement component C9
    MSDS:
    Please sign in first.
    CLIA Kit for Human Complement component C9
    MSDS:
    Please sign in first.
    CLIA Kit for Human Complement component C9
    MSDS:
    Please sign in first.
    CLIA Kit for Human Complement component C9
    MSDS:
    Please sign in first.
    CLIA Kit for Human Complement component C9
    Cat.:
    U14963h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Complement component C9
    Cat.:
    U14963m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Complement component C9
    Polyclonal Antibody for Human Complement component C9
    Polyclonal Antibody for Human Complement component C9
    Polyclonal Antibody for Human Complement component C9
    Polyclonal Antibody for Human Complement component C9
    Monoclonal Antibody for Human Complement component C9
    Monoclonal Antibody for Human Complement component C9
    Monoclonal Antibody for Human Complement component C9
    Monoclonal Antibody for Human Complement component C9
    Monoclonal Antibody for Human Complement component C9
    Protein for Human Complement component C9
    Protein for Human Complement component C9
    Protein for Human Complement component C9
    Protein for Human Complement component C9
    Protein for Human Complement component C9

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "The sequence and topology of human complement component C9."
      Stanley K.K. , Kocher H.-P. , Luzio J.P. , Jackson P. , Tschopp J.
      EMBO J.4:375-382(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Liver.
    3. 3.
      "Nucleotide sequence of cDNA and derived amino acid sequence of human complement component C9."
      Discipio R.G. , Gehring M.R. , Podack E.R. , Kan C.C. , Hugli T.E. , Fey G.H.
      Proc. Natl. Acad. Sci. U.S.A.81:7298-7302(1984) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-559;PROTEIN SEQUENCE OF N-TERMINUS
    4. 4.
      "Relationships between the gene and protein structure in human complement component C9."
      Marazziti D. , Eggertsen G. , Fey G.H. , Stanley K.K.
      Biochemistry27:6529-6534(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 62-159
    5. 5.
      "Heterogeneity in the genetic basis of human complement C9 deficiency."
      Witzel-Schloemp K. , Hobart M.J. , Fernie B.A. , Orren A. , Wuerzner R. , Rittner C. , Kaufmann T. , Schneider P.M.
      Immunogenetics48:144-147(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 27-559;VARIANT C9D GLY-119
    6. 6.
      "The architecture of complement component C9 and poly(C9)."
      DiScipio R.G. , Hugli T.E.
      J. Biol. Chem.260:14802-14809(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE;ELECTRON MICROSCOPY;GLYCOSYLATION AT ASN-277 AND ASN-415
    7. 7.
      "Identification of disulfide bonds in the ninth component (C9) of human complement."
      Lengweiler S. , Schaller J. , Rickli E.E.
      FEBS Lett.380:8-12(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISULFIDE BONDS
    8. 8.
      "The four terminal components of the complement system are C-mannosylated on multiple tryptophan residues."
      Hofsteenge J. , Blommers M. , Hess D. , Furmanek A. , Miroshnichenko O.
      J. Biol. Chem.274:32786-32794(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT TRP-48 AND TRP-51
    9. 9.
      "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."
      Bunkenborg J. , Pilch B.J. , Podtelejnikov A.V. , Wisniewski J.R.
      Proteomics4:454-465(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-415
      tissue: Plasma.
    10. 10.
      "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
      J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-277 AND ASN-415
      tissue: Plasma.
    11. 11.
      "Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."
      Lewandrowski U. , Moebius J. , Walter U. , Sickmann A.
      Mol. Cell. Proteomics5:226-233(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-415
      tissue: Platelet.
    12. 12.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-277 AND ASN-415
      tissue: Liver.
    13. 13.
      "A strategy for precise and large scale identification of core fucosylated glycoproteins."
      Jia W. , Lu Z. , Fu Y. , Wang H.P. , Wang L.H. , Chi H. , Yuan Z.F. , Zheng Z.B. , Song L.N. , Han H.H. , Liang Y.M. , Wang J.L. , Cai Y. , Zhang Y.K. , Deng Y.L. , Ying W.T. , He S.M. , Qian X.H.
      Mol. Cell. Proteomics8:913-923(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-415
    14. 14.
      "Localization and molecular modelling of the membrane-inserted domain of the ninth component of human complement and perforin."
      Peitsch M.C. , Amiguet P. , Guy R. , Brunner J. , Maizel J.V. Jr. , Tschopp J.
      Mol. Immunol.27:589-602(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: 3D-STRUCTURE MODELING OF MEMBRANE-SPANNING DOMAIN (MSB)
    15. 15.
      "Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration."
      Seddon J.M. , Yu Y. , Miller E.C. , Reynolds R. , Tan P.L. , Gowrisankar S. , Goldstein J.I. , Triebwasser M. , Anderson H.E. , Zerbib J. , Kavanagh D. , Souied E. , Katsanis N. , Daly M.J. , Atkinson J.P. , Raychaudhuri S.
      Nat. Genet.45:1366-1370(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ARMD15 SER-167
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