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Index > Protein center > COL18A1(Gene name) > Human
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  • COL18A1 (Gene name),
  • Collagen alpha-1(XVIII) chain (Protein name ),  COIA1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    COL18A1;
    Protein name:
    Collagen alpha-1(XVIII) chain;
    Alternative:
    Endostatin;
    Organism:
    COL18A1 (Homo sapiens). 
    General Annotation
    Sub Unit:
    Function:
    Endostatin potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling.
    Subcellular Location:
    Secreted extracellular space extracellular matrix
    Protein Attributes:
    Sequence length:
    1754
    Sequence:
    50:
    MAPYPCGCHI | LLLLFCCLAA | ARANLLNLNW | LWFNNEDTSH | AATTIPEPQG | 
    100:
    PLPVQPTADT | TTHVTPRNGS | TEPATAPGSP | EPPSELLEDG | QDTPTSAESP | 
    150:
    DAPEENIAGV | GAEILNVAKG | IRSFVQLWND | TVPTESLARA | ETLVLETPVG | 
    200:
    PLALAGPSST | PQENGTTLWP | SRGIPSSPGA | HTTEAGTLPA | PTPSPPSLGR | 
    250:
    PWAPLTGPSV | PPPSSGRASL | SSLLGGAPPW | GSLQDPDSQG | LSPAAAAPSQ | 
    300:
    QLQRPDVRLR | TPLLHPLVMG | SLGKHAAPSA | FSSGLPGALS | QVAVTTLTRD | 
    350:
    SGAWVSHVAN | SVGPGLANNS | ALLGADPEAP | AGRCLPLPPS | LPVCGHLGIS | 
    400:
    RFWLPNHLHH | ESGEQVRAGA | RAWGGLLQTH | CHPFLAWFFC | LLLVPPCGSV | 
    450:
    PPPAPPPCCQ | FCEALQDACW | SRLGGGRLPV | ACASLPTQED | GYCVLIGPAA | 
    500:
    ERISEEVGLL | QLLGDPPPQQ | VTQTDDPDVG | LAYVFGPDAN | SGQVARYHFP | 
    550:
    SLFFRDFSLL | FHIRPATEGP | GVLFAITDSA | QAMVLLGVKL | SGVQDGHQDI | 
    600:
    SLLYTEPGAG | QTHTAASFRL | PAFVGQWTHL | ALSVAGGFVA | LYVDCEEFQR | 
    650:
    MPLARSSRGL | ELEPGAGLFV | AQAGGADPDK | FQGVIAELKV | RRDPQVSPMH | 
    700:
    CLDEEGDDSD | GASGDSGSGL | GDARELLREE | TGAALKPRLP | APPPVTTPPL | 
    750:
    AGGSSTEDSR | SEEVEEQTTV | ASLGAQTLPG | SDSVSTWDGS | VRTPGGRVKE | 
    800:
    GGLKGQKGEP | GVPGPPGRAG | PPGSPCLPGP | PGLPCPVSPL | GPAGPALQTV | 
    850:
    PGPQGPPGPP | GRDGTPGRDG | EPGDPGEDGK | PGDTGPQGFP | GTPGDVGPKG | 
    900:
    DKGDPGVGER | GPPGPQGPPG | PPGPSFRHDK | LTFIDMEGSG | FGGDLEALRG | 
    950:
    PRGFPGPPGP | PGVPGLPGEP | GRFGVNSSDV | PGPAGLPGVP | GREGPPGFPG | 
    1000:
    LPGPPGPPGR | EGPPGRTGQK | GSLGEAGAPG | HKGSKGAPGP | AGARGESGLA | 
    1050:
    GAPGPAGPPG | PPGPPGPPGP | GLPAGFDDME | GSGGPFWSTA | RSADGPQGPP | 
    1100:
    GLPGLKGDPG | VPGLPGAKGE | VGADGVPGFP | GLPGREGIAG | PQGPKGDRGS | 
    1150:
    RGEKGDPGKD | GVGQPGLPGP | PGPPGPVVYV | SEQDGSVLSV | PGPEGRPGFA | 
    1200:
    GFPGPAGPKG | NLGSKGERGS | PGPKGEKGEP | GSIFSPDGGA | LGPAQKGAKG | 
    1250:
    EPGFRGPPGP | YGRPGYKGEI | GFPGRPGRPG | MNGLKGEKGE | PGDASLGFGM | 
    1300:
    RGMPGPPGPP | GPPGPPGTPV | YDSNVFAESS | RPGPPGLPGN | QGPPGPKGAK | 
    1350:
    GEVGPPGPPG | QFPFDFLQLE | AEMKGEKGDR | GDAGQKGERG | EPGGGGFFGS | 
    1400:
    SLPGPPGPPG | PPGPRGYPGI | PGPKGESIRG | QPGPPGPQGP | PGIGYEGRQG | 
    1450:
    PPGPPGPPGP | PSFPGPHRQT | ISVPGPPGPP | GPPGPPGTMG | ASSGVRLWAT | 
    1500:
    RQAMLGQVHE | VPEGWLIFVA | EQEELYVRVQ | NGFRKVQLEA | RTPLPRGTDN | 
    1550:
    EVAALQPPVV | QLHDSNPYPR | REHPHPTARP | WRADDILASP | PRLPEPQPYP | 
    1600:
    GAPHHSSYVH | LRPARPTSPP | AHSHRDFQPV | LHLVALNSPL | SGGMRGIRGA | 
    1650:
    DFQCFQQARA | VGLAGTFRAF | LSSRLQDLYS | IVRRADRAAV | PIVNLKDELL | 
    1700:
    FPSWEALFSG | SEGPLKPGAR | IFSFDGKDVL | RHPTWPQKSV | WHGSDPNGRR | 
    1750:
    LTESYCETWR | TEAPSATGQA | SSLLGGRLLG | QSAASCHHAY | IVLCIENSFM | 
    1754:
    TASK
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    KEGG:
    MIM:
    UniGene:
    SMR:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Collagen alpha-1(XVIII) chain
    Cat.:
    E1823h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Collagen alpha-1(XVIII) chain
    Cat.:
    E1823m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Collagen alpha-1(XVIII) chain
    Cat.:
    U1823h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Collagen alpha-1(XVIII) chain
    Cat.:
    U1823m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Collagen alpha-1(XVIII) chain
    Cat.:
    P1823Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Collagen alpha-1(XVIII) chain
    Cat.:
    P1823Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Collagen alpha-1(XVIII) chain
    Monoclonal Antibody for Human Collagen alpha-1(XVIII) chain
    Protein for Human Collagen alpha-1(XVIII) chain
    Protein for Human Collagen alpha-1(XVIII) chain

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Complete primary structure of two variant forms of human type XVIII collagen and tissue-specific differences in the expression of the corresponding transcripts."
      Saarela J. , Ylikarppa R. , Rehn M. , Purmonen S. , Pihlajaniemi T.
      Matrix Biol.16:319-328(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3);VARIANT ILE-1076
    2. 2.
      "Characterization of the human type XVIII collagen gene and proteolytic processing and tissue location of the variant containing a frizzled motif."
      Elamaa H. , Snellman A. , Rehn M. , Autio-Harmainen H. , Pihlajaniemi T.
      Matrix Biol.22:427-442(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1; 2 AND 3);VARIANTS ILE-1076 AND ASN-1675
    3. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3);VARIANT ILE-1076
      tissue: Kidney.
      tissue: PNS.
    4. 5.
      "Cloning of cDNA and genomic DNA encoding human type XVIII collagen and localization of the alpha 1(XVIII) collagen gene to mouse chromosome 10 and human chromosome 21."
      Oh S.P. , Warman M.L. , Seldin M.F. , Cheng S. , Knoll J.H. , Timmons S. , Olsen B.R.
      Genomics19:494-499(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1069-1754;VARIANT ARG-1121
    5. 6.
      "Inhibition effect in vitro of purified endostatin expressed in Pichia pastoris."
      Feng Y. , Cui L.B. , Liu C.X. , Ma Q.J.
      Sheng Wu Gong Cheng Xue Bao17:278-282(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1568-1754
    6. 7.
      "Cloning and expression of human endostatin gene in Escherichia coli."
      Zhi-Yong H. , Biao L. , Wei-Jie Z. , Xiang-Fu W.
      Submitted (1999-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1572-1754;VARIANT ASN-1675
      tissue: Placenta.
    7. 8.
      "Endostatin promotes delayed secondary damage following traumatic brain injury."
      Deininger M.H. , Trautmann K. , Schluesener H.J.
      Submitted (2001-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1642-1743
    8. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN KNO1
    9. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 1572-1749;ZINC-BINDING SITE
    10. 11.
      "Collagen XVIII, containing an endogenous inhibitor of angiogenesis and tumor growth, plays a critical role in the maintenance of retinal structure and in neural tube closure."
      Sertie A.L. , Sossi V. , Camargo A.A. , Zatz M. , Brahe C. , Passos-Bueno M.R.
      Hum. Mol. Genet.9:2051-2058(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN KNO1
    11. 12.
      "A polymorphism in endostatin, an angiogenesis inhibitor, predisposes for the development of prostatic adenocarcinoma."
      Iughetti P. , Suzuki O. , Godoi P.H. , Alves V.A. , Sertie A.L. , Zorick T. , Soares F. , Camargo A.A. , Moreira E.S. , di Loreto C. , Moreira-Filho C.A. , Simpson A. , Oliva G. , Passos-Bueno M.R.
      Cancer Res.61:7375-7378(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ILE-1076 AND ASN-1675
    12. 13.
      "Knobloch syndrome: novel mutations in COL18A1, evidence for genetic heterogeneity, and a functionally impaired polymorphism in endostatin."
      Menzel O. , Bekkeheien R.C.J. , Reymond A. , Fukai N. , Boye E. , Kosztolanyi G. , Aftimos S. , Deutsch S. , Scott H.S. , Olsen B.R. , Antonarakis S.E. , Guipponi M.
      Hum. Mutat.23:77-84(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS LEU-49; ARG-111; ILE-1076 AND ARG-1121;CHARACTERIZATION OF VARIANT ASN-1675
    13. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] ARG-1121
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