Language:
  
[Sign in] [Register]   

EIAab logo

Index > Protein center > CYP2B6(Gene name) > Human
  • Add your favorite
  • CYP2B6 (Gene name),
  • Cytochrome P450 2B6 (Protein name ),  CP2B6_HUMAN from NCBI database.
  • top
  • Come back to page head.
  • |
  • General Annotation
  • |
  • Antigen Annotation
  • |
  • 3D
  • |
  • Predicted Eptitope
  • |
  • Vaild Sequence
  • |
  • Related Databases
  • |
  • Feedback
  • Gene name:
    CYP2B6;
    Protein name:
    Cytochrome P450 2B6;
    Alternative:
    Cytochrome P450 IIB1;CYPIIB6;Cytochrome P450 IIB1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
    Subcellular Location:
    Endoplasmic reticulum membrane Peripheral membrane protein Microsome membrane Peripheral membrane protein
    Protein Attributes:
    Sequence length:
    491
    Sequence:
    50:
    MELSVLLFLA | LLTGLLLLLV | QRHPNTHDRL | PPGPRPLPLL | GNLLQMDRRG | 
    100:
    LLKSFLRFRE | KYGDVFTVHL | GPRPVVMLCG | VEAIREALVD | KAEAFSGRGK | 
    150:
    IAMVDPFFRG | YGVIFANGNR | WKVLRRFSVT | TMRDFGMGKR | SVEERIQEEA | 
    200:
    QCLIEELRKS | KGALMDPTFL | FQSITANIIC | SIVFGKRFHY | QDQEFLKMLN | 
    250:
    LFYQTFSLIS | SVFGQLFELF | SGFLKYFPGA | HRQVYKNLQE | INAYIGHSVE | 
    300:
    KHRETLDPSA | PKDLIDTYLL | HMEKEKSNAH | SEFSHQNLNL | NTLSLFFAGT | 
    350:
    ETTSTTLRYG | FLLMLKYPHV | AERVYREIEQ | VIGPHRPPEL | HDRAKMPYTE | 
    400:
    AVIYEIQRFS | DLLPMGVPHI | VTQHTSFRGY | IIPKDTEVFL | ILSTALHDPH | 
    450:
    YFEKPDAFNP | DHFLDANGAL | KKTEAFIPFS | LGKRICLGEG | IARAELFLFF | 
    491:
    TTILQNFSMA | SPVAPEDIDL | TPQECGVGKI | PPTYQIRFLP | R
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    Pfam:
    MIM:
    SMR:
    UniGene:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Cytochrome P450 2B6
    Cat.:
    E0221h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Cytochrome P450 2B6
    Cat.:
    U0221h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Human Cytochrome P450 2B6
    Cat.:
    P0221Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Cytochrome P450 2B6
    Protein for Human Cytochrome P450 2B6

    R&D Technical Data
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Precision
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Recovery
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Linearity
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "cDNA cloning and sequence and cDNA-directed expression of human P450 IIB1: identification of a normal and two variant cDNAs derived from the CYP2B locus on chromosome 19 and differential expression of the IIB mRNAs in human liver."
      Yamano S. , Nhamburo P.T. , Aoyama T. , Meyer U.A. , Inaba T. , Kalow W. , Gelboin H.V. , McBride O.W. , Gonzalez F.J.
      Biochemistry28:7340-7348(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Liver.
    2. 2.
      "Sequence of a new human cytochrome P450-2B6 cDNA."
      Zhuge J. , Qian Y. , Xie H. , Yu Y.
      Submitted (1999-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS ALA-167; HIS-172 AND ARG-262
      tissue: Liver.
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Colon.
    4. 4.
      NIEHS SNPs program
      Submitted (2005-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS CYS-22; SER-26; GLY-28; SER-29; HIS-172; ARG-262; LYS-289; SER-306; THR-328 AND CYS-487
    5. 5.
      "The DNA sequence and biology of human chromosome 19."
      Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
      Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "Alternative splicing in the human cytochrome P450IIB6 gene generates a high level of aberrant messages."
      Miles J.S. , McLaren A.W. , Wolf C.R.
      Nucleic Acids Res.17:8241-8255(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 26-491 (ISOFORM 1)
    7. 7.
      "Gene expression in distinct regions of the heart."
      Thum T. , Borlak J.
      Lancet355:979-983(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    8. 8.
      "Roles of cytochrome P450 3A enzymes in the 2-hydroxylation of 1,4-cineole, a monoterpene cyclic ether, by rat and human liver microsomes."
      Miyazawa M. , Shindo M. , Shimada T.
      Xenobiotica31:713-723(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY;FUNCTION AS 1,4-CINEOLE 2-EXO-MONOOXYGENASE;BIOPHYSICOCHEMICAL PROPERTIES
    9. 9.
      "Crystal structure of a cytochrome P450 2B6 genetic variant in complex with the inhibitor 4-(4-chlorophenyl)imidazole at 2.0-A resolution."
      Gay S.C. , Shah M.B. , Talakad J.C. , Maekawa K. , Roberts A.G. , Wilderman P.R. , Sun L. , Yang J.Y. , Huelga S.C. , Hong W.X. , Zhang Q. , Stout C.D. , Halpert J.R.
      Mol. Pharmacol.77:529-538(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 30-491 OF VARIANT ARG-262 IN COMPLEX WITH HEME AND SYNTHETIC INHIBITOR;FUNCTION;COFACTOR;IDENTIFICATION BY MASS SPECTROMETRY
    10. 10.
      "Structures of cytochrome P450 2B6 bound to 4-benzylpyridine and 4-(4-nitrobenzyl)pyridine: insight into inhibitor binding and rearrangement of active site side chains."
      Shah M.B. , Pascual J. , Zhang Q. , Stout C.D. , Halpert J.R.
      Mol. Pharmacol.80:1047-1055(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 30-491 OF VARIANT ARG-262 IN COMPLEX WITH HEME AND SYNTHETIC INHIBITOR;FUNCTION;COFACTOR
    11. 11.
      "Conformational adaptation of human cytochrome P450 2B6 and rabbit cytochrome P450 2B4 revealed upon binding multiple amlodipine molecules."
      Shah M.B. , Wilderman P.R. , Pascual J. , Zhang Q. , Stout C.D. , Halpert J.R.
      Biochemistry51:7225-7238(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 30-491 IN COMPLEX WITH HEME AND AMLODIPINE;FUNCTION;COFACTOR
    12. 12.
      "Pharmacogenetics of efavirenz and central nervous system side effects: an Adult AIDS Clinical Trials Group study."
      Haas D.W. , Ribaudo H.J. , Kim R.B. , Tierney C. , Wilkinson G.R. , Gulick R.M. , Clifford D.B. , Hulgan T. , Marzolini C. , Acosta E.P.
      AIDS18:2391-2400(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POLYMORPHISM;INVOLVEMENT IN EFAVIRENZ POOR METABOLISM;SUSCEPTIBILITY TO EFAVIRENZ TOXICITY
    13. 13.
      "Haplotype structure of CYP2B6 and association with plasma efavirenz concentrations in a Chilean HIV cohort."
      Carr D.F. , la Porte C.J. , Pirmohamed M. , Owen A. , Cortes C.P.
      J. Antimicrob. Chemother.65:1889-1893(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POLYMORPHISM;INVOLVEMENT IN EFAVIRENZ POOR METABOLISM;SUSCEPTIBILITY TO EFAVIRENZ TOXICITY
    14. 14.
      "Influence of host genetic factors on efavirenz plasma and intracellular pharmacokinetics in HIV-1-infected patients."
      Elens L. , Vandercam B. , Yombi J.C. , Lison D. , Wallemacq P. , Haufroid V.
      Pharmacogenomics11:1223-1234(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POLYMORPHISM;INVOLVEMENT IN EFAVIRENZ POOR METABOLISM;SUSCEPTIBILITY TO EFAVIRENZ TOXICITY
    15. 15.
      "A single nucleotide polymorphism of CYP2b6 found in Japanese enhances catalytic activity by autoactivation."
      Ariyoshi N. , Miyazaki M. , Toide K. , Sawamura Y.I. , Kamataki T.
      Biochem. Biophys. Res. Commun.281:1256-1260(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HIS-172
    16. 16.
      "Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver."
      Lang T. , Klein K. , Fischer J. , Nussler A.K. , Neuhaus P. , Hofmann U. , Eichelbaum M. , Schwab M. , Zanger U.M.
      Pharmacogenetics11:399-415(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CYS-22; HIS-172; ARG-259; ARG-262 AND CYS-487
    17. 17.
      "Functional characterization of cytochrome P450 2B6 allelic variants."
      Jinno H. , Tanaka-Kagawa T. , Ohno A. , Makino Y. , Matsushima E. , Hanioka N. , Ando M.
      Drug Metab. Dispos.31:398-403(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANTS CYS-22; HIS-172; ARG-259; ARG-262 AND CYS-487
    18. 18.
      "Catalog of 680 variations among eight cytochrome p450 (CYP) genes, nine esterase genes, and two other genes in the Japanese population."
      Saito S. , Iida A. , Sekine A. , Kawauchi S. , Higuchi S. , Ogawa C. , Nakamura Y.
      J. Hum. Genet.48:249-270(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CYS-22; ALA-167; HIS-172 AND CYS-487
    19. 19.
      "Hepatic CYP2B6 expression: gender and ethnic differences and relationship to CYP2B6 genotype and CAR (constitutive androstane receptor) expression."
      Lamba V. , Lamba J. , Yasuda K. , Strom S. , Davila J. , Hancock M.L. , Fackenthal J.D. , Rogan P.K. , Ring B. , Wrighton S.A. , Schuetz E.G.
      J. Pharmacol. Exp. Ther.307:906-922(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CYS-22; GLU-139; HIS-172 AND CYS-487
    20. 20.
      "Multiple novel nonsynonymous CYP2B6 gene polymorphisms in Caucasians: demonstration of phenotypic null alleles."
      Lang T. , Klein K. , Richter T. , Zibat A. , Kerb R. , Eichelbaum M. , Schwab M. , Zanger U.M.
      J. Pharmacol. Exp. Ther.311:34-43(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS LEU-21; VAL-46; GLU-99; GLU-139; GLN-140 AND ASN-391
    21. 21.
      "Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population."
      Solus J.F. , Arietta B.J. , Harris J.R. , Sexton D.P. , Steward J.Q. , McMunn C. , Ihrie P. , Mehall J.M. , Edwards T.L. , Dawson E.P.
      Pharmacogenomics5:895-931(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CYS-22; HIS-172; ARG-262; THR-328 AND CYS-487
    Product Feedback Wall
    Hot Genes
    Atf2 ASPRO ACE ALCAM C19orf80 Trap1a KSR2 Gdf5
    Top Searches
    Ubiquitin-protein ligase Ubiquitin ELISA metalloproteinase Tumor necrosis Asprosin TRAP1A Alpha
    Why choose EIAAB
    Our products have been quoted by many publications in famous journals such as Cell; Cell Metabolism; Hepatology; Biomaterials.more
    Further Information
    About us Protein center Bank account Distributors Terms & Conditions Career eiaab.cn

    Copyright & copy www.eiaab.com2006-2016 All Rights Reserved    EIAab         Email:eiaab@eiaab.com

    Twitter