CYP2B6 ELISA Kit for Human(Homo sapiens) | EIAab.comCYP2B6 ELISA Kit for Human(Homo sapiens) | EIAab.com

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CYP2B6 (Gene name),

Cytochrome P450 2B6 (Protein name ), CP2B6_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Gene name:

CYP2B6;

Protein name:

Cytochrome P450 2B6;

Alternative:

Cytochrome P450 IIB1;CYPIIB6;Cytochrome P450 IIB1;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Subcellular Location:

Endoplasmic reticulum membrane Peripheral membrane protein Microsome membrane Peripheral membrane protein

Protein Attributes:

Sequence length:

491

Sequence:

50:

MELSVLLFLA | LLTGLLLLLV | QRHPNTHDRL | PPGPRPLPLL | GNLLQMDRRG |

100:

LLKSFLRFRE | KYGDVFTVHL | GPRPVVMLCG | VEAIREALVD | KAEAFSGRGK |

150:

IAMVDPFFRG | YGVIFANGNR | WKVLRRFSVT | TMRDFGMGKR | SVEERIQEEA |

200:

QCLIEELRKS | KGALMDPTFL | FQSITANIIC | SIVFGKRFHY | QDQEFLKMLN |

250:

LFYQTFSLIS | SVFGQLFELF | SGFLKYFPGA | HRQVYKNLQE | INAYIGHSVE |

300:

KHRETLDPSA | PKDLIDTYLL | HMEKEKSNAH | SEFSHQNLNL | NTLSLFFAGT |

350:

ETTSTTLRYG | FLLMLKYPHV | AERVYREIEQ | VIGPHRPPEL | HDRAKMPYTE |

400:

AVIYEIQRFS | DLLPMGVPHI | VTQHTSFRGY | IIPKDTEVFL | ILSTALHDPH |

450:

YFEKPDAFNP | DHFLDANGAL | KKTEAFIPFS | LGKRICLGEG | IARAELFLFF |

491:

TTILQNFSMA | SPVAPEDIDL | TPQECGVGKI | PPTYQIRFLP | R

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

STRING:

9606.ENSP00000324648

Pfam:

MIM:

SMR:

UniGene:

KEGG:

Uniprot:

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ELISA Kit for Human Cytochrome P450 2B6

Cat.:

E0221h

Price:

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Manual:

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MSDS:

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Packing:

96T

Range:

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CLIA Kit for Human Cytochrome P450 2B6

Cat.:

U0221h

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Manual:

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MSDS:

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Packing:

96T

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Polyclonal Antibody for Human Cytochrome P450 2B6

Cat.:

P0221Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Cytochrome P450 2B6

Protein for Human Cytochrome P450 2B6

R&D Technical Data

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"cDNA cloning and sequence and cDNA-directed expression of human P450 IIB1: identification of a normal and two variant cDNAs derived from the CYP2B locus on chromosome 19 and differential expression of the IIB mRNAs in human liver."
Yamano S. , Nhamburo P.T. , Aoyama T. , Meyer U.A. , Inaba T. , Kalow W. , Gelboin H.V. , McBride O.W. , Gonzalez F.J.
Biochemistry28:7340-7348(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Liver.
2.

"Sequence of a new human cytochrome P450-2B6 cDNA."
Zhuge J. , Qian Y. , Xie H. , Yu Y.
Submitted (1999-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS ALA-167; HIS-172 AND ARG-262
tissue: Liver.
3.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Colon.
4.

NIEHS SNPs program
Submitted (2005-11) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS CYS-22; SER-26; GLY-28; SER-29; HIS-172; ARG-262; LYS-289; SER-306; THR-328 AND CYS-487
5.

"The DNA sequence and biology of human chromosome 19."
Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"Alternative splicing in the human cytochrome P450IIB6 gene generates a high level of aberrant messages."
Miles J.S. , McLaren A.W. , Wolf C.R.
Nucleic Acids Res.17:8241-8255(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 26-491 (ISOFORM 1)
7.

"Gene expression in distinct regions of the heart."
Thum T. , Borlak J.
Lancet355:979-983(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
8.

"Roles of cytochrome P450 3A enzymes in the 2-hydroxylation of 1,4-cineole, a monoterpene cyclic ether, by rat and human liver microsomes."
Miyazawa M. , Shindo M. , Shimada T.
Xenobiotica31:713-723(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY;FUNCTION AS 1,4-CINEOLE 2-EXO-MONOOXYGENASE;BIOPHYSICOCHEMICAL PROPERTIES
9.

"Crystal structure of a cytochrome P450 2B6 genetic variant in complex with the inhibitor 4-(4-chlorophenyl)imidazole at 2.0-A resolution."
Gay S.C. , Shah M.B. , Talakad J.C. , Maekawa K. , Roberts A.G. , Wilderman P.R. , Sun L. , Yang J.Y. , Huelga S.C. , Hong W.X. , Zhang Q. , Stout C.D. , Halpert J.R.
Mol. Pharmacol.77:529-538(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 30-491 OF VARIANT ARG-262 IN COMPLEX WITH HEME AND SYNTHETIC INHIBITOR;FUNCTION;COFACTOR;IDENTIFICATION BY MASS SPECTROMETRY
10.

"Structures of cytochrome P450 2B6 bound to 4-benzylpyridine and 4-(4-nitrobenzyl)pyridine: insight into inhibitor binding and rearrangement of active site side chains."
Shah M.B. , Pascual J. , Zhang Q. , Stout C.D. , Halpert J.R.
Mol. Pharmacol.80:1047-1055(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 30-491 OF VARIANT ARG-262 IN COMPLEX WITH HEME AND SYNTHETIC INHIBITOR;FUNCTION;COFACTOR
11.

"Conformational adaptation of human cytochrome P450 2B6 and rabbit cytochrome P450 2B4 revealed upon binding multiple amlodipine molecules."
Shah M.B. , Wilderman P.R. , Pascual J. , Zhang Q. , Stout C.D. , Halpert J.R.
Biochemistry51:7225-7238(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 30-491 IN COMPLEX WITH HEME AND AMLODIPINE;FUNCTION;COFACTOR
12.

"Pharmacogenetics of efavirenz and central nervous system side effects: an Adult AIDS Clinical Trials Group study."
Haas D.W. , Ribaudo H.J. , Kim R.B. , Tierney C. , Wilkinson G.R. , Gulick R.M. , Clifford D.B. , Hulgan T. , Marzolini C. , Acosta E.P.
AIDS18:2391-2400(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POLYMORPHISM;INVOLVEMENT IN EFAVIRENZ POOR METABOLISM;SUSCEPTIBILITY TO EFAVIRENZ TOXICITY
13.

"Haplotype structure of CYP2B6 and association with plasma efavirenz concentrations in a Chilean HIV cohort."
Carr D.F. , la Porte C.J. , Pirmohamed M. , Owen A. , Cortes C.P.
J. Antimicrob. Chemother.65:1889-1893(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POLYMORPHISM;INVOLVEMENT IN EFAVIRENZ POOR METABOLISM;SUSCEPTIBILITY TO EFAVIRENZ TOXICITY
14.

"Influence of host genetic factors on efavirenz plasma and intracellular pharmacokinetics in HIV-1-infected patients."
Elens L. , Vandercam B. , Yombi J.C. , Lison D. , Wallemacq P. , Haufroid V.
Pharmacogenomics11:1223-1234(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POLYMORPHISM;INVOLVEMENT IN EFAVIRENZ POOR METABOLISM;SUSCEPTIBILITY TO EFAVIRENZ TOXICITY
15.

"A single nucleotide polymorphism of CYP2b6 found in Japanese enhances catalytic activity by autoactivation."
Ariyoshi N. , Miyazaki M. , Toide K. , Sawamura Y.I. , Kamataki T.
Biochem. Biophys. Res. Commun.281:1256-1260(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HIS-172
16.

"Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver."
Lang T. , Klein K. , Fischer J. , Nussler A.K. , Neuhaus P. , Hofmann U. , Eichelbaum M. , Schwab M. , Zanger U.M.
Pharmacogenetics11:399-415(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CYS-22; HIS-172; ARG-259; ARG-262 AND CYS-487
17.

"Functional characterization of cytochrome P450 2B6 allelic variants."
Jinno H. , Tanaka-Kagawa T. , Ohno A. , Makino Y. , Matsushima E. , Hanioka N. , Ando M.
Drug Metab. Dispos.31:398-403(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANTS CYS-22; HIS-172; ARG-259; ARG-262 AND CYS-487
18.

"Catalog of 680 variations among eight cytochrome p450 (CYP) genes, nine esterase genes, and two other genes in the Japanese population."
Saito S. , Iida A. , Sekine A. , Kawauchi S. , Higuchi S. , Ogawa C. , Nakamura Y.
J. Hum. Genet.48:249-270(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CYS-22; ALA-167; HIS-172 AND CYS-487
19.

"Hepatic CYP2B6 expression: gender and ethnic differences and relationship to CYP2B6 genotype and CAR (constitutive androstane receptor) expression."
Lamba V. , Lamba J. , Yasuda K. , Strom S. , Davila J. , Hancock M.L. , Fackenthal J.D. , Rogan P.K. , Ring B. , Wrighton S.A. , Schuetz E.G.
J. Pharmacol. Exp. Ther.307:906-922(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CYS-22; GLU-139; HIS-172 AND CYS-487
20.

"Multiple novel nonsynonymous CYP2B6 gene polymorphisms in Caucasians: demonstration of phenotypic null alleles."
Lang T. , Klein K. , Richter T. , Zibat A. , Kerb R. , Eichelbaum M. , Schwab M. , Zanger U.M.
J. Pharmacol. Exp. Ther.311:34-43(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS LEU-21; VAL-46; GLU-99; GLU-139; GLN-140 AND ASN-391
21.

"Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population."
Solus J.F. , Arietta B.J. , Harris J.R. , Sexton D.P. , Steward J.Q. , McMunn C. , Ihrie P. , Mehall J.M. , Edwards T.L. , Dawson E.P.
Pharmacogenomics5:895-931(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CYS-22; HIS-172; ARG-262; THR-328 AND CYS-487

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