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Index > Protein center > CRYM(Gene name) > Human
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  • CRYM (Gene name),
  • Thiomorpholine-carboxylate dehydrogenase (Protein name ),  CRYM_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Vaild Sequence
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  • Gene name:
    CRYM(THBP);
    Protein name:
    Thiomorpholine-carboxylate dehydrogenase;
    Alternative:
    Mu-crystallin homolog;ketimine reductase;NADP-regulated thyroid-hormone-binding protein;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer.
    Function:
    Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    314
    Sequence:
    50:
    MSRVPAFLSA | AEVEEHLRSS | SLLIPPLETA | LANFSSGPEG | GVMQPVRTVV | 
    100:
    PVTKHRGYLG | VMPAYSAAED | ALTTKLVTFY | EDRGITSVVP | SHQATVLLFE | 
    150:
    PSNGTLLAVM | DGNVITAKRT | AAVSAIATKF | LKPPSSEVLC | ILGAGVQAYS | 
    200:
    HYEIFTEQFS | FKEVRIWNRT | KENAEKFADT | VQGEVRVCSS | VQEAVAGADV | 
    250:
    IITVTLATEP | ILFGEWVKPG | AHINAVGASR | PDWRELDDEL | MKEAVLYVDS | 
    300:
    QEAALKESGD | VLLSGAEIFA | ELGEVIKGVK | PAHCEKTTVF | KSLGMAVEDT | 
    314:
    VAAKLIYDSW | SSGK
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    KEGG:
    Pfam:
    UniGene:
    String:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Thiomorpholine-carboxylate dehydrogenase
    Cat.:
    E11761h
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    96T
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    ELISA Kit for Human Thiomorpholine-carboxylate dehydrogenase
    MSDS:
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    ELISA Kit for Human Thiomorpholine-carboxylate dehydrogenase
    Cat.:
    E11761m
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Thiomorpholine-carboxylate dehydrogenase
    Cat.:
    E11761r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Thiomorpholine-carboxylate dehydrogenase
    MSDS:
    Please sign in first.
    CLIA Kit for Human Thiomorpholine-carboxylate dehydrogenase
    Cat.:
    U11761h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Thiomorpholine-carboxylate dehydrogenase
    Cat.:
    U11761r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Thiomorpholine-carboxylate dehydrogenase
    Cat.:
    U11761m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Thiomorpholine-carboxylate dehydrogenase
    Polyclonal Antibody for Human Thiomorpholine-carboxylate dehydrogenase
    Polyclonal Antibody for Human Thiomorpholine-carboxylate dehydrogenase
    Cat.:
    P11761Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Thiomorpholine-carboxylate dehydrogenase
    Monoclonal Antibody for Human Thiomorpholine-carboxylate dehydrogenase
    Monoclonal Antibody for Human Thiomorpholine-carboxylate dehydrogenase
    Monoclonal Antibody for Human Thiomorpholine-carboxylate dehydrogenase
    Monoclonal Antibody for Human Thiomorpholine-carboxylate dehydrogenase
    Protein for Human Thiomorpholine-carboxylate dehydrogenase
    Protein for Human Thiomorpholine-carboxylate dehydrogenase
    Protein for Human Thiomorpholine-carboxylate dehydrogenase
    Protein for Human Thiomorpholine-carboxylate dehydrogenase

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    Precision
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    Linearity
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    References
    1. 1.
      "Two roles for mu-crystallin: a lens structural protein in diurnal marsupials and a possible enzyme in mammalian retinas."
      Segovia L. , Horwitz J. , Gasser R. , Wistow G.
      Mol. Vis.3:9-9(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Retina.
    2. 2.
      "Purification, molecular cloning, and functional expression of the human nicotinamide-adenine dinucleotide phosphate-regulated thyroid hormone-binding protein."
      Vie M.-P. , Evrard C. , Osty J. , Breton-Gilet A. , Blanchet P. , Pomerance M. , Rouget P. , Francon J. , Blondeau J.-P.
      Mol. Endocrinol.11:1728-1736(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Brain.
    3. 3.
      "Human and mouse Mu-crystallin."
      Sperbeck S.J. , Segovia L. , Wistow G.J.
      Submitted (1997-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q."
      Loftus B.J. , Kim U.-J. , Sneddon V.P. , Kalush F. , Brandon R. , Fuhrmann J. , Mason T. , Crosby M.L. , Barnstead M. , Cronin L. , Mays A.D. , Cao Y. , Xu R.X. , Kang H.-L. , Mitchell S. , Eichler E.E. , Harris P.C. , Venter J.C. , more...
      Genomics60:295-308(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Uterine endothelium.
    7. 7.
      "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J. , Han C. , Gordon L.A. , Terry A. , Prabhakar S. , She X. , Xie G. , Hellsten U. , Chan Y.M. , Altherr M. , Couronne O. , Aerts A. , Bajorek E. , Black S. , Blumer H. , Branscomb E. , Brown N.C. , Bruno W.J. , more...
      Nature432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    10. 10.
      Lubec G. , Afjehi-Sadat L. , Chen W.-Q. , Sun Y.
      Submitted (2008-12) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 4-18; 57-83; 177-186; 243-277 AND 292-314;IDENTIFICATION BY MASS SPECTROMETRY
      tissue: Brain.
      tissue: Cajal-Retzius cell.
      tissue: Fetal brain cortex.
    11. 11.
      "Mu-crystallin is a mammalian homologue of Agrobacterium ornithine cyclodeaminase and is expressed in human retina."
      Kim R.Y. , Gasser R. , Wistow G.J.
      Proc. Natl. Acad. Sci. U.S.A.89:9292-9296(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE OF 37-314
      tissue: Retina.
    12. 12.
      "Mammalian forebrain ketimine reductase identified as mu-crystallin; potential regulation by thyroid hormones."
      Hallen A. , Cooper A.J. , Jamie J.F. , Haynes P.A. , Willows R.D.
      J. Neurochem.118:379-387(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS A KETIMINE REDUCTASE;CATALYTIC ACTIVITY;KINETIC PARAMETERS;PH DEPENDENCE;COFACTOR
    13. 13.
      "Crystal structure of human micro-crystallin complexed with NADPH."
      Cheng Z. , Sun L. , He J. , Gong W.
      Protein Sci.16:329-335(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 2-313 IN COMPLEX WITH NADPH;SUBUNIT;NADP-BINDING SITES
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