CSK ELISA Kit for Human(Homo sapiens) | EIAab.comCSK ELISA Kit for Human(Homo sapiens)

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Index > Protein center > CSK(Gene name) > Human

CSK (Gene name),

Tyrosine-protein kinase CSK (Protein name ), CSK_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

CSK;

Protein name:

Tyrosine-protein kinase CSK;

Alternative:

Protein-tyrosine kinase CYL;C-Src kinase;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with PTPN8 (By similarity). Interacts with phosphorylated SIT1, PAG1, LIME1 and TGFB1I1. Interacts with SRCIN1.

Function:

Specifically phosphorylates 'Tyr-504' on LCK, which acts as a negative regulatory site. Can also act on the LYN and FYN kinases.

Subcellular Location:

Cytoplasm Cell membrane Mainly cytoplasmic, also present in lipid rafts.

Protein Attributes:

Sequence length:

450

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P41240

MIM:

124095

Pfam:

PF07714

String:

P41240

STRING:

9606.ENSP00000220003

UniGene:

Hs.77793

KEGG:

hsa:1445

Uniprot:

P41240

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ELISA Kit for Human Tyrosine-protein kinase CSK

Cat.:

E11982h

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96T

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ELISA Kit for Human Tyrosine-protein kinase CSK

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ELISA Kit for Human Tyrosine-protein kinase CSK

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ELISA Kit for Human Tyrosine-protein kinase CSK

Cat.:

E11982m

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Packing:

96T

ELISA Kit for Human Tyrosine-protein kinase CSK

Cat.:

E11982r

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Packing:

96T

CLIA Kit for Human Tyrosine-protein kinase CSK

Cat.:

U11982m

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Packing:

96T

CLIA Kit for Human Tyrosine-protein kinase CSK

MSDS:

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CLIA Kit for Human Tyrosine-protein kinase CSK

MSDS:

Please sign in first.

CLIA Kit for Human Tyrosine-protein kinase CSK

Cat.:

U11982h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

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CLIA Kit for Human Tyrosine-protein kinase CSK

Cat.:

U11982r

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96T

Polyclonal Antibody for Human Tyrosine-protein kinase CSK

Cat.:

P11982Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Tyrosine-protein kinase CSK

Monoclonal Antibody for Human Tyrosine-protein kinase CSK

Protein for Human Tyrosine-protein kinase CSK

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"CYL encodes a putative cytoplasmic tyrosine kinase lacking the conserved tyrosine autophosphorylation site (Y416src)."
Partanen J. , Armstrong E. , Bergman M. , Maekelae T.P. , Hirvonen H. , Huebner K. , Alitalo K.
Oncogene6:2013-2018(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"Two additional protein-tyrosine kinases expressed in human lung: fourth member of the fibroblast growth factor receptor family and an intracellular protein-tyrosine kinase."
Braeuninger A. , Holtrich U. , Strebhardt K. , Ruebsamen-Waigmann H.
Proc. Natl. Acad. Sci. U.S.A.88:10411-10415(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Lung.
3.

"Isolation and characterization of a human gene that encodes a new subclass of protein tyrosine kinases."
Brauninger A. , Holtrich U. , Strebhardt K. , Rubsamen-Waigmann H.
Gene110:205-211(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];TISSUE SPECIFICITY
4.

"Characterization of the human CSK locus."
Braeuninger A. , Karn T. , Strebhardt K. , Ruebsamen-Waigmann H.
Oncogene8:1365-1369(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
5.

"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Halleck A. , Ebert L. , Mkoundinya M. , Schick M. , Eisenstein S. , Neubert P. , Kstrang K. , Schatten R. , Shen B. , Henze S. , Mar W. , Korn B. , Zuo D. , Hu Y. , LaBaer J.
Submitted (2004-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
6.

NIEHS SNPs program
Submitted (2005-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ASP-287; GLN-398 AND ARG-442
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Brain.
tissue: Uterus.
8.

"The human p50csk tyrosine kinase phosphorylates p56lck at Tyr-505 and down regulates its catalytic activity."
Bergman M. , Mustelin T. , Oetken C. , Partanen J. , Flint N.A. , Amrein K.E. , Autero M. , Burn P. , Alitalo K.
EMBO J.11:2919-2924(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF LCK
9.

"Recombinant Csk expressed in Escherichia coli is autophosphorylated on tyrosine residue(s)."
Bougeret C. , Rothhut B. , Jullien P. , Fischer S. , Benarous R.
Oncogene8:1241-1247(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: AUTOPHOSPHORYLATION
10.

"Expression, purification, and initial characterization of human Yes protein tyrosine kinase from a bacterial expression system."
Sun G. , Budde R.J.
Arch. Biochem. Biophys.345:135-142(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF YES1
11.

"Identification of csk tyrosine phosphorylation sites and a tyrosine residue important for kinase domain structure."
Joukov V. , Vihinen M. , Vainikka S. , Sowadski J.M. , Alitalo K. , Bergman M.
Biochem. J.322:927-935(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-184 AND TYR-304;MUTAGENESIS OF TYR-184 AND TYR-304
12.

"Phosphorylation of Hic-5 at tyrosine 60 by CAKbeta and Fyn."
Ishino M. , Aoto H. , Sasaski H. , Suzuki R. , Sasaki T.
FEBS Lett.474:179-183(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TGFB1I1
13.

"Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation."
Brdicka T. , Pavlistova D. , Bruyns E. , Leo A. , Korinek V. , Angelisova P. , Scherer J. , Shevchenko A. , Shevchenko A. , Hilgert I. , Cerny J. , Drbal K. , Kuramitsu Y. , Horejsi V. , Schraven B.
J. Exp. Med.191:1591-1604(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PAG1
14.

"Structural and functional dissection of the cytoplasmic domain of the transmembrane adaptor protein SIT (SHP2-interacting transmembrane adaptor protein)."
Pfrepper K.-I. , Marie-Cardine A. , Simeoni L. , Kuramitsu Y. , Leo A. , Spicka J. , Hilgert I. , Scherer J. , Schraven B.
Eur. J. Immunol.31:1825-1836(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SIT1
15.

"Activation of the COOH-terminal Src kinase (Csk) by cAMP-dependent protein kinase inhibits signaling through the T cell receptor."
Vang T. , Torgersen K.M. , Sundvold V. , Saxena M. , Levy F.O. , Skalhegg B.S. , Hansson V. , Mustelin T. , Tasken K.
J. Exp. Med.193:497-507(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-364 BY PKA;MUTAGENESIS OF SER-364
16.

"LIME: a new membrane raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling."
Brdickova N. , Brdicka T. , Angelisova P. , Horvath O. , Spicka J. , Hilgert I. , Paces J. , Simeoni L. , Kliche S. , Merten C. , Schraven B. , Horejsi V.
J. Exp. Med.198:1453-1462(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LIME1
17.

"C-terminal Src kinase (CSK) and CSK-homologous kinase (CHK)--endogenous negative regulators of Src-family protein kinases."
Chong Y.P. , Mulhern T.D. , Cheng H.C.
Growth Factors23:233-244(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
18.

"p140Cap protein suppresses tumour cell properties, regulating Csk and Src kinase activity."
Di Stefano P. , Damiano L. , Cabodi S. , Aramu S. , Tordella L. , Praduroux A. , Piva R. , Cavallo F. , Forni G. , Silengo L. , Tarone G. , Turco E. , Defilippi P.
EMBO J.26:2843-2855(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SRCIN1
19.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
20.

"The tyrosine kinase Csk dimerizes through Its SH3 domain."
Levinson N.M. , Visperas P.R. , Kuriyan J.
PLoS ONE4:E7683-E7683(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: HOMODIMERIZATION
21.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
22.

"RhoH modulates pre-TCR and TCR signalling by regulating LCK."
Wang H. , Zeng X. , Fan Z. , Lim B.
Cell. Signal.23:249-258(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RHOH
23.

"SCIMP, a transmembrane adapter protein involved in major histocompatibility complex class II signaling."
Draber P. , Vonkova I. , Stepanek O. , Hrdinka M. , Kucova M. , Skopcova T. , Otahal P. , Angelisova P. , Horejsi V. , Yeung M. , Weiss A. , Brdicka T.
Mol. Cell. Biol.31:4550-4562(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SCIMP
24.

"The crystal structure of human CskSH3: structural diversity near the RT-Src and n-Src loop."
Borchert T.V. , Mathieu M. , Zeelen J.P. , Courtneidge S.A. , Wierenga R.K.
FEBS Lett.341:79-85(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 1-71
25.

"Patterns of somatic mutation in human cancer genomes."
Greenman C. , Stephens P. , Smith R. , Dalgliesh G.L. , Hunter C. , Bignell G. , Davies H. , Teague J. , Butler A. , Stevens C. , Edkins S. , O'Meara S. , Vastrik I. , Schmidt E.E. , Avis T. , Barthorpe S. , Bhamra G. , Buck G. , more...
Nature446:153-158(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-45

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