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Index > Protein center > CSK(Gene name) > Human
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  • CSK (Gene name),
  • Tyrosine-protein kinase CSK (Protein name ),  CSK_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    CSK;
    Protein name:
    Tyrosine-protein kinase CSK;
    Alternative:
    Protein-tyrosine kinase CYL;C-Src kinase;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with PTPN8 (By similarity). Interacts with phosphorylated SIT1, PAG1, LIME1 and TGFB1I1. Interacts with SRCIN1.
    Function:
    Specifically phosphorylates 'Tyr-504' on LCK, which acts as a negative regulatory site. Can also act on the LYN and FYN kinases.
    Subcellular Location:
    Cytoplasm Cell membrane Mainly cytoplasmic, also present in lipid rafts.
    Protein Attributes:
    Sequence length:
    450
    Sequence:
    50:
    MSAIQAAWPS | GTECIAKYNF | HGTAEQDLPF | CKGDVLTIVA | VTKDPNWYKA | 
    100:
    KNKVGREGII | PANYVQKREG | VKAGTKLSLM | PWFHGKITRE | QAERLLYPPE | 
    150:
    TGLFLVREST | NYPGDYTLCV | SCDGKVEHYR | IMYHASKLSI | DEEVYFENLM | 
    200:
    QLVEHYTSDA | DGLCTRLIKP | KVMEGTVAAQ | DEFYRSGWAL | NMKELKLLQT | 
    250:
    IGKGEFGDVM | LGDYRGNKVA | VKCIKNDATA | QAFLAEASVM | TQLRHSNLVQ | 
    300:
    LLGVIVEEKG | GLYIVTEYMA | KGSLVDYLRS | RGRSVLGGDC | LLKFSLDVCE | 
    350:
    AMEYLEGNNF | VHRDLAARNV | LVSEDNVAKV | SDFGLTKEAS | STQDTGKLPV | 
    400:
    KWTAPEALRE | KKFSTKSDVW | SFGILLWEIY | SFGRVPYPRI | PLKDVVPRVE | 
    450:
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    MIM:
    Pfam:
    String:
    UniGene:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Tyrosine-protein kinase CSK
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    E11982h
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    96T
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    ELISA Kit for Human Tyrosine-protein kinase CSK
    MSDS:
    Please sign in first.
    ELISA Kit for Human Tyrosine-protein kinase CSK
    MSDS:
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    ELISA Kit for Human Tyrosine-protein kinase CSK
    Cat.:
    E11982m
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Tyrosine-protein kinase CSK
    Cat.:
    E11982r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Tyrosine-protein kinase CSK
    Cat.:
    U11982m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Tyrosine-protein kinase CSK
    MSDS:
    Please sign in first.
    CLIA Kit for Human Tyrosine-protein kinase CSK
    MSDS:
    Please sign in first.
    CLIA Kit for Human Tyrosine-protein kinase CSK
    Cat.:
    U11982h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Tyrosine-protein kinase CSK
    Cat.:
    U11982r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Tyrosine-protein kinase CSK
    Cat.:
    P11982Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Tyrosine-protein kinase CSK
    Polyclonal Antibody for Human Tyrosine-protein kinase CSK
    Polyclonal Antibody for Human Tyrosine-protein kinase CSK
    Polyclonal Antibody for Human Tyrosine-protein kinase CSK
    Monoclonal Antibody for Human Tyrosine-protein kinase CSK
    Monoclonal Antibody for Human Tyrosine-protein kinase CSK
    Monoclonal Antibody for Human Tyrosine-protein kinase CSK
    Monoclonal Antibody for Human Tyrosine-protein kinase CSK
    Monoclonal Antibody for Human Tyrosine-protein kinase CSK
    Protein for Human Tyrosine-protein kinase CSK
    Protein for Human Tyrosine-protein kinase CSK
    Protein for Human Tyrosine-protein kinase CSK
    Protein for Human Tyrosine-protein kinase CSK
    Protein for Human Tyrosine-protein kinase CSK

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "CYL encodes a putative cytoplasmic tyrosine kinase lacking the conserved tyrosine autophosphorylation site (Y416src)."
      Partanen J. , Armstrong E. , Bergman M. , Maekelae T.P. , Hirvonen H. , Huebner K. , Alitalo K.
      Oncogene6:2013-2018(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Two additional protein-tyrosine kinases expressed in human lung: fourth member of the fibroblast growth factor receptor family and an intracellular protein-tyrosine kinase."
      Braeuninger A. , Holtrich U. , Strebhardt K. , Ruebsamen-Waigmann H.
      Proc. Natl. Acad. Sci. U.S.A.88:10411-10415(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Lung.
    3. 3.
      "Isolation and characterization of a human gene that encodes a new subclass of protein tyrosine kinases."
      Brauninger A. , Holtrich U. , Strebhardt K. , Rubsamen-Waigmann H.
      Gene110:205-211(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];TISSUE SPECIFICITY
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    5. 5.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A. , Ebert L. , Mkoundinya M. , Schick M. , Eisenstein S. , Neubert P. , Kstrang K. , Schatten R. , Shen B. , Henze S. , Mar W. , Korn B. , Zuo D. , Hu Y. , LaBaer J.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    6. 6.
      NIEHS SNPs program
      Submitted (2005-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ASP-287; GLN-398 AND ARG-442
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
      tissue: Uterus.
    8. 8.
      "The human p50csk tyrosine kinase phosphorylates p56lck at Tyr-505 and down regulates its catalytic activity."
      Bergman M. , Mustelin T. , Oetken C. , Partanen J. , Flint N.A. , Amrein K.E. , Autero M. , Burn P. , Alitalo K.
      EMBO J.11:2919-2924(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF LCK
    9. 9.
      "Recombinant Csk expressed in Escherichia coli is autophosphorylated on tyrosine residue(s)."
      Bougeret C. , Rothhut B. , Jullien P. , Fischer S. , Benarous R.
      Oncogene8:1241-1247(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: AUTOPHOSPHORYLATION
    10. 10.
      "Expression, purification, and initial characterization of human Yes protein tyrosine kinase from a bacterial expression system."
      Sun G. , Budde R.J.
      Arch. Biochem. Biophys.345:135-142(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF YES1
    11. 11.
      "Identification of csk tyrosine phosphorylation sites and a tyrosine residue important for kinase domain structure."
      Joukov V. , Vihinen M. , Vainikka S. , Sowadski J.M. , Alitalo K. , Bergman M.
      Biochem. J.322:927-935(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-184 AND TYR-304;MUTAGENESIS OF TYR-184 AND TYR-304
    12. 12.
      "Phosphorylation of Hic-5 at tyrosine 60 by CAKbeta and Fyn."
      Ishino M. , Aoto H. , Sasaski H. , Suzuki R. , Sasaki T.
      FEBS Lett.474:179-183(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TGFB1I1
    13. 13.
      "Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation."
      Brdicka T. , Pavlistova D. , Bruyns E. , Leo A. , Korinek V. , Angelisova P. , Scherer J. , Shevchenko A. , Shevchenko A. , Hilgert I. , Cerny J. , Drbal K. , Kuramitsu Y. , Horejsi V. , Schraven B.
      J. Exp. Med.191:1591-1604(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PAG1
    14. 14.
      "Structural and functional dissection of the cytoplasmic domain of the transmembrane adaptor protein SIT (SHP2-interacting transmembrane adaptor protein)."
      Pfrepper K.-I. , Marie-Cardine A. , Simeoni L. , Kuramitsu Y. , Leo A. , Spicka J. , Hilgert I. , Scherer J. , Schraven B.
      Eur. J. Immunol.31:1825-1836(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SIT1
    15. 15.
      "Activation of the COOH-terminal Src kinase (Csk) by cAMP-dependent protein kinase inhibits signaling through the T cell receptor."
      Vang T. , Torgersen K.M. , Sundvold V. , Saxena M. , Levy F.O. , Skalhegg B.S. , Hansson V. , Mustelin T. , Tasken K.
      J. Exp. Med.193:497-507(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-364 BY PKA;MUTAGENESIS OF SER-364
    16. 16.
      "LIME: a new membrane raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling."
      Brdickova N. , Brdicka T. , Angelisova P. , Horvath O. , Spicka J. , Hilgert I. , Paces J. , Simeoni L. , Kliche S. , Merten C. , Schraven B. , Horejsi V.
      J. Exp. Med.198:1453-1462(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LIME1
    17. 17.
      "C-terminal Src kinase (CSK) and CSK-homologous kinase (CHK)--endogenous negative regulators of Src-family protein kinases."
      Chong Y.P. , Mulhern T.D. , Cheng H.C.
      Growth Factors23:233-244(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    18. 18.
      "p140Cap protein suppresses tumour cell properties, regulating Csk and Src kinase activity."
      Di Stefano P. , Damiano L. , Cabodi S. , Aramu S. , Tordella L. , Praduroux A. , Piva R. , Cavallo F. , Forni G. , Silengo L. , Tarone G. , Turco E. , Defilippi P.
      EMBO J.26:2843-2855(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SRCIN1
    19. 19.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
    20. 20.
      "The tyrosine kinase Csk dimerizes through Its SH3 domain."
      Levinson N.M. , Visperas P.R. , Kuriyan J.
      PLoS ONE4:E7683-E7683(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: HOMODIMERIZATION
    21. 21.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    22. 22.
      "RhoH modulates pre-TCR and TCR signalling by regulating LCK."
      Wang H. , Zeng X. , Fan Z. , Lim B.
      Cell. Signal.23:249-258(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RHOH
    23. 23.
      "SCIMP, a transmembrane adapter protein involved in major histocompatibility complex class II signaling."
      Draber P. , Vonkova I. , Stepanek O. , Hrdinka M. , Kucova M. , Skopcova T. , Otahal P. , Angelisova P. , Horejsi V. , Yeung M. , Weiss A. , Brdicka T.
      Mol. Cell. Biol.31:4550-4562(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SCIMP
    24. 24.
      "The crystal structure of human CskSH3: structural diversity near the RT-Src and n-Src loop."
      Borchert T.V. , Mathieu M. , Zeelen J.P. , Courtneidge S.A. , Wierenga R.K.
      FEBS Lett.341:79-85(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 1-71
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